Clinical trials: Non-invasive
Hematologic Malignancy
Non Invasive Optical Imaging of WBC Count
This research study is looking at a small device that measures white blood cell (WBC) counts by being placed against the finger nail for participants who are undergoing stem cell transplantation at Massachusetts General Hospital…
- Trial name
- NCT02512666
- Testing
- AM4113-N5UT Dino-Lite
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Coronary Plaques
Prospective Identification of High-risk Coronary Plaques Through Non-invasive Imaging
Cardiovascular disease remains the leading cause of death worldwide. Identifying individual patients at risk of a suture adverse events, including myocardial infractions (heart attacks), remains a major diagnostic challenge.
- Trial name
- NCT02347306
- Testing
- Telephone interview
- Volunteers
- 100 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Non-muscle Invasive Bladder Cancer
Validation of a Urine-based Assay With Genomic Markers for Predicting Recurrence for Non-muscle Invasive Bladder Cancer
A study to validate, in a prospective manner, the ability of the predefined Genomic Health bladder cancer assay to detect recurrence in patients undergoing surveillance for non-muscle invasive bladder cancer.
- Trial name
- NCT02969109
- Where
- United States
- Volunteers
- 417 people
- Sponsor
- Genomic Health®, Inc.
Covid19
Early Use of Hyperimmune Plasma in COVID-19
The study assesses the efficacy of early administration of hyperimmune plasma in covid-19 patients who are on CPAP or intubated. Efficacy is measured as a 2 point decrease in the WHO scale
- Trial name
- COV-II-PLA (NCT04721236)
- Testing
- hyperimmune plasma
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Catherine Klersy
Tattoo; Pigmentation
Clinical Study to Evaluate the Performance of the PicoWayTM 1064 nm/ 785 nm/ 532nm Picosecond Laser for Tattoo Removal
This is an open-label, multi-center study. Subjects in this study will receive up to eight (8) treatments in 11±5 weeks (6-16 weeks) interval, with the PicoWayTM device using the 1064 nm/ 785±20 nm/ 532 nm handpiece according to…
- Trial name
- NCT02700932
- Testing
- PicoWay
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Post Herpetic Neuralgia (PHN)
Transcutaneous Auricular Vagus Nerve Stimulation on Post-Herpetic Neuralgia
The purpose of this study is to evaluate the therapeutic efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of patients with post-herpetic neuralgia (PHN).
- Trial name
- NCT07123987
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), traditional medical treatment for PHN
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Mohamed Hosny Ismail Easa
Physical Deconditioning
Effects of Training With a Pressure Cuff on Cellular Energy Activity
This study investigates low-load, cuff-assisted training to improve mitochondrial capacity. The intervention is carried out using automated pressure cuffs, applying an individualized pressure of 70% of the limb occlusion…
- Trial name
- NCT07494721
- Testing
- Application of pressure cuffs during strength training, Application of pressure cuffs during endurance training, Conventional clinical rehabilitation program without the use of pressure cuffs
- Volunteers
- 51 people
- Sponsor
- Spital Thurgau AG
Physical Inactivity, Sedentary Behavior
Physical Activity as a Non-Invasive Strategy to Address Obesity and Musculoskeletal Risk in First-Year University Students: A Cross-Sectional Study in Spain
The aim of this retrospective cross-sectional study was to assess physical activity and sedentary behavior levels in first-year university students and to explore their association with obesity and musculoskeletal health risk…
- Conditions
- Physical Inactivity, Sedentary Behavior, Obesity & Overweight
- Trial name
- NCT07392593
- Where
- Spain
- Volunteers
- 821 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
COVID19, Oxygen Therapy
Impact of Prone Position in Patients Under Spontaneous Breathing on Intubation or Non-invasive Ventilation or Death Incidence During COVID-19 Acute Respiratory Distress
The SARS-Cov2 viral pandemic is responsible for a new infectious disease called COVID-19 (CoronaVIrus Disease), is a major health problem.
- Conditions
- COVID19, Oxygen Therapy, Prone Position, Spontaneous Ventilation
- Trial name
- PROVID-19 (NCT04363463)
- Testing
- prone position
- Where
- 19 sites in France, Monaco
- Volunteers
- 268 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Chronic Obstructive Pulmonary Disease With Acute Exacerbation, Unspecified
Comparison of Two Oxygen Setting During Non-invasive Mechanical Ventilation of Chronic Obstructive Pulmonary Disease
Hypoxaemic patients with exacerbations of chronic obstructive pulmonary disease (COPD) are at some risk of carbon dioxide (CO2) retention during oxygen therapy.
- Trial name
- OXYSET (NCT02563314)
- Testing
- Non-invasive mechanical ventilation - Normoxia, Non-invasive mechanical ventilation - Controlled hypoxemia
- Where
- 4 sites in France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Coronary Artery Disease, Microcirculation Resistance
COronoary Microcirculation Analysis NETwork
COMA.NET (Coronary Microcirculation Analysis Network) is a prospective, randomized, open-label, parallel-group clinical trial designed to determine whether endotype-guided pharmacotherapy is superior to standard care in improving…
- Conditions
- Coronary Artery Disease, Microcirculation Resistance, Microcirculation; Biomarkers; Myocardial Ischemia, Microcirculatory Dysfunction
- Trial name
- COMA-NET (NCT07498231)
- Testing
- Coronary microvascular function assessment
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Bialystok
Stroke
Non-invasive VNS in Stroke Recovery
To evaluate feasibility and effectiveness of non-invasive VNS to enhance stroke recovery
- Trial name
- NOVUS (NCT06761404)
- Testing
- taVNS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Methodist Hospital Research Institute
Autism Spectrum Disorder
Autism Research Project With Non-Invasive Near-Infrared Light Stimulation
The investigators have previously shown that the administration of low-level infrared light is a safe and non-invasive procedure which improves cognition and emotion, as well as enhances brain metabolic activity.
- Trial name
- NCT06203938
- Testing
- Transcranial infrared light stimulation
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Francisco Gonzalez-Lima, PhD
Heart Transplantation, Rejection Heart Transplant
Evaluation of the Added Clinical Value of Donor-derived Cell-free DNA for the Monitoring of Cardiac Allograft Rejection.
The goal of this observational study is to assess the clinical added value of donor-derived cell-free DNA (dd-cfDNA) to monitor cardiac allograft rejection.
- Trial name
- HEART-FREE (NCT06740578)
- Where
- 2 sites in France
- Volunteers
- 320 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Diabetes Mellitus, Type 1, Diabetes Mellitus
Urine Extracellular Vesicles: Non-invasive Biomarkers of Β-cell Function and Novel Therapeutic Agents in Diabetes
Diabetes mellitus is a common chronic disease with a huge socioeconomic burden worldwide. Type 1 Diabetes(T1D) accounts for nearly 95% of diabetes in pediatric age and a lifelong dependence on exogenous insulin.
- Trial name
- EvsBioDiabetes (NCT06832215)
- Testing
- Blood and urine samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Skin Laxity
Safety and Efficacy of the BTL-785F Device for Non-invasive Reduction of Submental Fat
This study will evaluate the clinical safety and the performance of the BTL-785F system equipped with the BTL-785-7 applicator for non-invasive reduction of submental fat and skin laxity treatment.
- Trial name
- NCT05831332
- Testing
- BTL-785-7
- Where
- Bulgaria
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Brain Hypoxia Ischemia
Continuous, Non-invasive Monitoring of Intraoperative Cerebral Perfusion and Oxidative Metabolism (CPOM)
This study uses a CPOM Optical neuromonitor to assess the relationship between brain cytochrome C oxidase, cerebral oxygen saturation and blood pressure during surgery performed under general anesthesia.
- Trial name
- NCT03907904
- Testing
- CPOM Optical Neuromonitor
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Non-melanoma Skin Cancer
Imaging Methods for the Diagnosis of Non-melanoma Skin Cancer and Its Precursors
Prospective, unicentric study that examines if imaging devices like total body photography, dermoscopy, optical coherence tomography and in vivo reflectance confocal microscopy as an addition to clinical examination lead to a…
- Trial name
- NCT05842421
- Testing
- optical coherence tomography, in vivo reflectance confocal microscopy, 3D total body photography
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Technische Universität Dresden
Urothelial Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma
Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE)
This trial aims at investigating the diagnostic ability of a combined diagnostic panel including systematic endoscopic evaluation (SEE), blood-based ctDNA assay, and urine-based cfDNA assay to predict the presence of residual…
- Conditions
- Urothelial Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma, Non-Muscle Invasive Bladder Urothelial Carcinoma
- Trial name
- INSITE (NCT06396533)
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- Fox Chase Cancer Center
Cerebral Aneurysms, Intracranial Aneurysms
NOn-inVAsive Blood Pressure Monitoring in Intracranial Aneurysm Embolization
The goal of this clinical trial is to evaluate whether non-invasive continuous blood pressure monitoring (NVBP) using the ClearSight system can safely serve as an alternative to radial arterial catheterization for invasive…
- Conditions
- Cerebral Aneurysms, Intracranial Aneurysms, Coil Embolization, Hemodynamic Instability
- Trial name
- NOVA (NCT07246148)
- Testing
- Non-invasive continuous blood pressure monitoring, Invasive arterial blood pressure monitoring
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Korea University Anam Hospital
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