Clinical trials: Non-invasive
Healthy
Influence of Fitzpatrick Skin Phototype and Body Mass Index on Non-invasive Optoacoustic Imaging
Multispectral Optoacoustic Tomography (MSOT) is a promising imaging technology that utilizes pulsed laser light. While melanin content in the skin has been reported to influence light-based measurements in pulse oximetry and…
- Trial name
- NCT06541496
- Testing
- Multispectral Optoacoustic Tomography (MSOT)
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cardiac Output
Non-invasive Cardiac Output Monitoring (esCCO™) in Critically Ill Patients Within ICU
Evaluation of a non-invasive technique to measure cardiac output (esCCO™) with the "clinical goldstandard" of the transcardiopulmonal thermodilution technique (PiCCO®).
- Trial name
- NCT02682615
- Where
- Germany
- Sponsor
- University Hospital Schleswig-Holstein
Non-invasive Ventilation, High-frequency Ventilation
Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation.
The purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.
- Conditions
- Non-invasive Ventilation, High-frequency Ventilation, Healthy Volunteer, Lung Diseases
- Trial name
- ANIV (NCT02712190)
- Testing
- High-frequency non-invasive ventilation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hemodynamics, Blood Pressure Monitoring
Non-Invasive Blood Pressure Monitoring in ICU Patients Using the DARE Device
This study tests a new non-invasive device called DARE to monitor blood pressure in patients in intensive care. It compares the device's readings to standard invasive methods and also looks at how well it measures other vital…
- Conditions
- Hemodynamics, Blood Pressure Monitoring, Intensive Care Units, Critical Illness
- Trial name
- NCT07052123
- Testing
- MultiSense® Non-Invasive Hemodynamic Monitoring Device
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier de Saint-Denis
COVID-19
Comparison of 2 Ventilatory Support Strategies During Coronavirus Disease 2019 (Covid-19) Pneumonia
This retrospective monocentric study compares 2 ventilatory support strategies on outcomes (length of stay, intubation, mortality) in patients admitted in Intensive Care Unit with Covid-19 related pneumonia : invasive strategy…
- Trial name
- STRATIC (NCT04799691)
- Testing
- Invasive ventilation strategy, Non-invasive ventilation strategies
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Non-metastatic Muscle Invasive Bladder Cancer
Avelumab as Neoadjuvant Therapy in Subjects With Urothelial Muscle Invasive Bladder Cancers (AURA Trial)
Open-label, interventional, multi-centre, randomized phase II study. Cancer studied is non-metastatic muscle invasive bladder cancer (MIBC).
- Trial name
- AURA (NCT03674424)
- Testing
- Avelumab, cystectomy, CG
- Where
- 10 sites in Belgium, France
- Volunteers
- 137 people
- Sponsor
- Jules Bordet Institute
Severe Bronchiolitis, Pediatric Respiratory Distress
NIV-NAVA in Infants With Severe Bronchiolitis, a Pilot Multicenter Randomized Controlled Trial
Severe bronchiolitis is a common lung infection in babies that can cause serious breathing problems and often leads to hospitalization in pediatric intensive care units (PICUs).
- Trial name
- NAVIGATE (NCT07834723)
- Testing
- NIV NAVA
- Where
- 4 sites in Canada
- Volunteers
- 90 people
- Sponsor
- St. Justine's Hospital
Care
Effect of Care Package on Duration of Stay and Physiological Parameters in Non-invasive Mechanical Ventilation
Temporary tachypnea of the newborn can be improved with minimal respiratory support and nursing care given to babies within the first 72 hours of life.
- Trial name
- NCT06189989
- Testing
- The group to which a care package was applied in addition to the clinical routine care protocol)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Okan University
Chronic Respiratory Failure With Hypercapnia
Impact of Humidification on Sleep Quality During Home Non Invasive Ventilation
Protocol Summary: 1. Question Does the adjunction of a humidification system to non-invasive ventilation circuit improve sleep quality and comfort of chronic ventilated respiratory insufficient patients? Does it change the…
- Trial name
- IMHUNIV (NCT03561974)
- Testing
- Humidification
- Where
- France
- Volunteers
- 30 people
- Sponsor
- ADIR Association
Urinary Bladder Neoplasms, BCG Vaccine
Multicenter Clinical Trial on the Effectiveness and Safety of Instillation of BCG and Alternative BCG Protocols for Intermediate and High-risk Non-muscle Invasive Bladder Cancer
Previous studies have reported the efficacy of Bacillus Calmette-Guérin (BCG) combined with other drugs for the treatment of bladder cancer.
- Conditions
- Urinary Bladder Neoplasms, BCG Vaccine, Immunotherapy, Active, Multicenter Study
- Trial name
- NCT06441110
- Testing
- Tislelizumab in Combination with Bacillus Calmette-Guérin
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Fujian Medical University Union Hospital
Intracranial Pressure Increase
Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy.
This is a single centre, observational study with a medical device which has Conformité Européenne (CE) marking. The aim of the study is to demonstrate that patients with malignant middle cerebral artery infarction (M-MCA) show…
- Trial name
- NCT03221959
- Testing
- Medical Device Vittamed 205
- Volunteers
- 48 people
- Sponsor
- Kienzler Jenny
Anemia
Validation of Non-Invasive Hemoglobin Measurement Using Optical Method for Anemia Screening Among Adults in Jakarta
Anemia remains a major public health concern and is commonly diagnosed through hemoglobin measurement using capillary or venous blood samples.
- Trial name
- SPECTRO-Hb (NCT07701499)
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07215299
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Breast Cancer, Colo-rectal Cancer
A Study of Biological, Genetic, and Constitutional Factors and Non-invasive Monitoring to Assess Personal Cancer Risks
The PRO-ACTIVE study aims to develop a clinical-translational program in the field of cancer prevention in all its phases (primary, secondary, and tertiary) to intervene before the clinical and radiological manifestation of the…
- Conditions
- Breast Cancer, Colo-rectal Cancer, Ovarian Cancer, Melanoma (Skin Cancer)
- Trial name
- PRO-ACTIVE (NCT07469709)
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Liver Diseases, Liver Cirrhosis
Non-invasive Ultrasound Diagnosis of Chronic Liver Diseases in Hepatology Consultation
Early screening and monitoring of chronic liver diseases in hepatology practice has become crucial. To achieve this goal, hepatology clinics need simple and available tools at the point-of-care to perform disease severity…
- Conditions
- Liver Diseases, Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease
- Trial name
- DIACEPA (NCT04782050)
- Testing
- Ultrasound liver assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- E-Scopics
Invasive Aspergillosis
Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis
The objective of this study is to evaluate the efficacy and safety of intravenous micafungin for the treatment of proven or probable fungal infections caused by Aspergillus sp.
- Trial name
- NCT02646774
- Testing
- Micafungin
- Where
- 19 sites in China
- Volunteers
- 43 people
- Sponsor
- Astellas Pharma China, Inc.
HDFN
Establish a Non-invasive Prenatal Genotyping and Extraction Technology to Diagnose and Treat the HDN.
To establish a genotyping and extraction technology of non invasive prenatal diagnosis for fetal blood group genotype from cell-free fetal DNA in peripheral blood of pregnant women.
- Trial name
- NCT02969174
- Testing
- zimin Lu,Guo Sa
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Type 1 Diabetes Mellitus With Diabetic Nephropathy
Validation of Biomarkers of Diabetic Nephropathy in Type I Diabetic Children
About 30 to 40% of patients suffering from type I diabetes are at risk of developing a diabetic nephropathy (DN) leading more or less rapidly to an end-stage renal disease.
- Trial name
- peeDIAB2 (NCT02164279)
- Testing
- Urinary sample collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Toulouse
Cardiac Arrest
Non Invasive Neuromonitoring After Cardiac Arrest
Cardiac Arrest is among the leading causes of death, with survival still well under 50% and the majority of the survivors suffering from moderate to severe neurologic deficits. The human, social and economic costs are staggering.
- Trial name
- NINCA (NCT02575196)
- Testing
- Non-invasive cerebral flow monitoring
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Liver Fibrosis
Evaluation of Innovative Ultrasonic Techniques for Non-invasive Diagnosis of Liver Fibrosis in Patients With Chronic Viral Hepatitis B or C
The non-invasive assessment of liver fibrosis in chronic viral hepatitis B and C is now entering clinical practice. It is based on blood tests, especially FibroMetre® and Fibrotest® and on elastography with the Fibroscan®.
- Trial name
- FIBRECHO (NCT01537965)
- Testing
- Fibroscan® of Echosens, Aixplorer® of Supersonic Imagine, Aplio XG of Toshiba, QRS software developed by Pr I.Bricault, Acuson S2000 of Siemens
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Grenoble
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