Clinical trials: Non-invasive Brain Stimulation
Stroke
Transcranial Stimulation in Motor Stroke Rehabilitation
Patients were randomized in 3 groups: two intervent groups and a control group. The first group received two weeks of daily session of repetitive Transcranial Magnetic Stimulation (rTMS, 10 sessions) and, at least 6 months after…
- Trial name
- NCT02525393
- Testing
- tDCS, rTMS
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Turin, Italy
Acute Ischemic Stroke
Study of the Effects of the Non-invasive Trigeminal Nerve Stimulation on Ischemic Stroke Patients
In patients with ischemic stroke, the primary focus revolves around enhancing the neuroprotective and rehabilitative effects of external trigeminal nerve stimulation (eTNS) and elucidating its underlying central mechanisms.
- Trial name
- NCT06540417
- Testing
- External trigeminal nerve stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xidian University
Persistent Post-concussive Symptoms
Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms
Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity.
- Trial name
- taVNS-PPCS (NCT07017257)
- Testing
- Active taVNS
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University of Liege
Deglutition, Physiology
Metaplasticity in Human Pharyngeal Motor Cortex
The purpose of the study is to determine the effects of giving 2 doses of brain stimulation through repetitive transcranial magnetic stimulation (rTMS) on swallowing neurophysiology (brain function) in healthy adults.
- Trial name
- NCT03705936
- Testing
- rTMS
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Feasibility Study, Post-Stroke Patients With Upper Extremity Motor Deficit
Contralesional Inhibitory rTMS for Recovery of Arm Function After Stroke
The CanStim consensus working group (multidisciplinary team of experts in rTMS from institutions across Canada) developed consensus recommendations for a protocol to deliver rTMS as an adjunct to a standard behavioral…
- Conditions
- Feasibility Study, Post-Stroke Patients With Upper Extremity Motor Deficit, Post-Stroke Patients With Cognitive Deficits
- Trial name
- ConTRAstroke (NCT04205526)
- Testing
- Active rTMS
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Thiel, Alexander, M.D.
Inflammatory Bowel Diseases (IBD), Remission of IBD
VIBRANT-IBD: Brain Effects of Non-Invasive Vagus Nerve Stimulation in IBD Remission
The VIBRANT-IBD study is a pilot, prospective, single-arm feasibility study investigating the effects of non-invasive vagus nerve stimulation (nVNS) in adults with inflammatory bowel disease (IBD) in clinical remission.
- Conditions
- Inflammatory Bowel Diseases (IBD), Remission of IBD, In Adults, Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
- Trial name
- VIBRANT-IBD (NCT07636304)
- Testing
- Non-invasive vagus nerve stimulation (nVNS)
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- University of Gdansk
Cerebrovascular Disorders, Healthy
Non-Invasive Electrical Stimulation of the Human Brain
This study is designed to allow researchers to use transelectrical stimulation to explore the function of the human nervous system and improve diagnosis of neurological disorders.
- Conditions
- Cerebrovascular Disorders, Healthy, Nervous System Diseases, Spinal Cord Injuries
- Trial name
- NCT00001216
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Generalized Anxiety Disorder (GAD)
MRI-Guided Accelerated cTBS for Generalized Anxiety Disorder
Generalized Anxiety Disorder (GAD) is a common psychiatric disorder associated with persistent anxiety, functional impairment, and incomplete response to existing treatments.
- Trial name
- NCT07640945
- Testing
- continuous theta burst stimulation(cTBS)
- Volunteers
- 75 people
- Sponsor
- Central South University
PTSD - Post Traumatic Stress Disorder
Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD
The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma.
- Trial name
- SPARK-VNS (NCT06953388)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wayne State University
Cortical Excitability, Brain Stimulation
Neuroplastic Alterations of the Motor Cortex by Caffeine
Caffeine is a psychostimulant drug. It acts as a competitive antagonist at adenosine receptors, which modulate cortical excitability as well.
- Conditions
- Cortical Excitability, Brain Stimulation, Caffeine
- Trial name
- NCT04011670
- Testing
- 200 mg caffeine tablet, Non-active tablet
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Suicidal Ideation Active, Depression Disorders
Personalized TACS to Reduce Rumination in Patients with Active Suicidal Ideation
The goal of this clinical trial is to determine whether modulating default mode network (DMN) alpha connectivity using transcranial alternating current stimulation (tACS) can reduce rumination and, in turn, mitigate feelings of…
- Trial name
- Alpha-MOD (NCT06832124)
- Testing
- alpha-tACS
- Volunteers
- 50 people
- Sponsor
- Sebastian Olbrich
PARKINSON DIS
Comparative Study of TIS Efficacy Across Different Targets
This prospective, randomized, participant- and outcome-assessor-blinded, parallel-group exploratory trial will compare the target-dependent clinical, neuroimaging, and electrophysiological effects of temporal interference…
- Trial name
- tTIS (NCT07745673)
- Testing
- TIS-STN, TIS-GP
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhongnan Hospital
Major Depressive Disorder
Amygdala TIS for Depression
The current investigation employs a directed neuromodulation technique, specifically targeting the right amygdala, to ascertain its therapeutic efficacy in managing depressive episodes.
- Trial name
- NCT06477276
- Testing
- Nervio-X
- Where
- 3 sites in China
- Volunteers
- 92 people
- Sponsor
- Ruijin Hospital
Stroke, Neglect, Hemispatial
tDCS in Post-stroke Neglect Rehabilitation
Introduction Stroke is the main cause of disability in the world and its sequelae have a great impact in the functional independence and quality of life of patients and families.
- Trial name
- tDCS-Neglect (NCT04458974)
- Testing
- Transcranial direct current stimulation, Neuropsychological rehabilitation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universitat Oberta de Catalunya