Clinical trials: Non-obstructive Coronary Artery Disease
Coronary Microvascular Disease, CMD
Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary…
- Trial name
- ExINOCA (NCT06529848)
- Testing
- Exercise training
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Bispebjerg Hospital
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Ticin Pilot Study: Sirolimus-Eluting Balloon for Stabilization and Regression of Non-Obstructive Coronary Plaques.
The goal of this pilot clinical trial is to evaluate the use of the Selution SLR sirolimus-eluting balloon, in addition to guideline-directed medical therapy (GDMT), for the preventive treatment of non-flow-limiting vulnerable…
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Multivessel Coronary Artery Disease, Coronary Vessel
- Trial name
- NCT06928883
- Testing
- Sirolimus drug eluting ballooon therapy, Optimal guidelines-directed medical therapies (GDMT)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Cardiocentro Ticino
PreDiabetes
Prediabetes and Non Obstructive Coronary Atherosclerosis.
Objectives: Prediabetes may condition an early endothelium dysfunction, and the development of non obstructive coronary stenosis (NOCS).
- Trial name
- NCT03553030
- Testing
- coronary artery angiography
- Where
- Italy
- Volunteers
- 172 people
- Sponsor
- University of Campania Luigi Vanvitelli
INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
RECOVER WITH INOCA: A Study of a Cardiac Rehabilitation Program in Patients With Ischemia With Nonobstructive Coronary Artery Disease (INOCA)
The goal of this clinical trial is to learn if a cardiac rehabilitation program (CRP) improves functional capacity in adults with INOCA (ischemia with non obstructive coronary arteries).
- Trial name
- NCT06887257
- Testing
- Telematic cardiac rehabilitation program, that includes exercise, educational and psychological sessions during 3 months, Standard recommendations
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Hospital Clinic of Barcelona
Coronary Vasospasm, Coronary Microvascular Dysfunction
The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)
The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational.
- Conditions
- Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis
- Trial name
- NL-CFT (NCT06083155)
- Testing
- Coronary Function Test, Patient questionnaires
- Where
- 15 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Starring Optical Coherence Tomography During Percutaneous Coronary Intervention Guidance
The starring optical coherence tomography during percutaneous coronary intervention guidance (OCT-AGEM) registry aims to evaluate the clinical impact of intra-procedural optical coherence tomography (OCT) in coronary…
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, MINOCA, INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
- Trial name
- OCT-AGEM (NCT07182799)
- Testing
- Plaque vulnerability assessment, Stent implantation optimization
- Where
- Italy
- Volunteers
- 3,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
ANOCA - Angina With Non-obstructive Coronary Arteries, INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing
This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary…
- Trial name
- CRT-NITRO (NCT06896903)
- Testing
- Coronary reactivity testing with and without nitrates
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Acute Coronary Syndrome
Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary Atherosclerosis
The purpose of the study is to assess short and long term outcomes of acute coronary syndrome in patients with non obstructive coronary atherosclerosis, to optimize the algorithm for diagnosis and to evaluate its effectiveness
- Trial name
- NOCA (NCT02655718)
- Testing
- Patients with ACS, MRI
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Russian Academy of Medical Sciences
Myocardial Infarction With Non-obstructive Coronary Arteries
Randomized Evaluation of Beta Blocker and ACEI/ARB Treatment in MINOCA Patients - MINOCA-BAT
Myocardial infarction with non-obstructive coronary arteries" (MINOCA) occurs in 5-10% of all patients with AMI. There are neither any randomized clinical trials in MINOCA patients evaluating effects of secondary preventive…
- Trial name
- MINOCA-BAT (NCT03686696)
- Testing
- Beta blocker, ACEI, ARB
- Where
- 32 sites in Australia, New Zealand and 3 more
- Volunteers
- 198 people
- Sponsor
- Uppsala University