Clinical trials: Non-smoker
Exercise Capacity
Cocoa Flavanols and Exercise Capacity
The purpose of this study is to characterize the potential improvement of cocoa flavanols on exercise capacity in highly trained cyclist.
- Trial name
- NCT01259739
- Testing
- Cocoa
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Tobacco Cessation
Intervention Study to Increase Smoking Cessation Rates Among Public Housing Residents
The purpose of this study is to determine whether public housing residents trained in Tobacco Cessation and Motivational Interviewing Techniques to become Tobacco Treatment Advocates(TTA) will be effective in increasing the quit…
- Trial name
- NCT01651611
- Testing
- Motivational interviewing, Smoking cessation counseling, Navigation to smoking cessation resources
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Boston University
Chronic Obstructive Pulmonary Disease
Phenotypes of COPD
Chronic Obstructive Pulmonary Disease (COPD) has been defined by international guidelines as a common preventable and treatable disease characterized by persistent air flow limitation and respiratory symptoms caused by exposure…
- Trial name
- NCT03432026
- Testing
- High resolution computed tomography scan of the chest.
- Volunteers
- 50 people
- Sponsor
- Assiut University
Hemodynamic Instability, Skin and Subcutaneous Tissue Disorders
Non Invasive Measurement of the Haemodynamic Parameters and of the Advanced Glycation End Products (AGEs) Levels
The aim of this study was to investigate the difference in accumulation of AGEs (advanced glycation end-products) in the tissues of individuals who smoke in comparison with individuals who do not as well as of individuals who…
- Trial name
- NONINVASHEMO (NCT02544165)
- Testing
- caffeine intake, cigarette smoking, Caffeine intake and Cigarette smoking
- Where
- Greece
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Technological Education Institute of Sterea Ellada
Tobacco Use Cessation
VergeRx for Smokers Not Ready to Quit
This study uses a factorial optimization experiment to identify which treatment components help adults who smoke and are not ready to quit in the next 30 days (smokers not ready to quit, or SNRTQ) achieve smoking cessation.
- Trial name
- NCT07693660
- Testing
- VergeRx, SmokefreeTXT, NRT Lozenge (Combination)
- Where
- United States
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Periodontitis, Smokers
This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients
This study is a randomized, controlled, split-mouth clinical trial designed to evaluate and compare the effectiveness of four different subgingival adjuncts used along side standard Scaling and Root Planning (SRP).
- Conditions
- Periodontitis, Smokers, Non Smokers, Periodontal Disease
- Trial name
- NCT07707063
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF), Diode Laser Activation, Povidone-Iodine Irrigation (1%)
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- Military Hospital of Tunis
Lung Cancer
Sputum Cytology in Screening Heavy Smokers For Lung Cancer
RATIONALE: Screening tests, such as sputum cytology, may help doctors find tumor cells early and plan better treatment for lung cancer.
- Trial name
- NCT00103363
- Testing
- cytology specimen collection procedure, physiologic testing, annual screening
- Where
- United States
- Volunteers
- 3,270 people
- Sponsor
- University of Colorado, Denver
Lung Cancer
S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
RATIONALE: Studying samples of blood and tissue from smokers (closed to entry as of 7/15/07) and non-smokers with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers…
- Trial name
- NCT00450281
- Testing
- chromogenic in situ hybridization, gene expression analysis, mutation analysis
- Where
- 405 sites in United States
- Volunteers
- 981 people
- Sponsor
- SWOG Cancer Research Network
Chronic Obstructive Pulmonary Disease (COPD), Smoking
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
The purpose of this study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Smoking, Smoking Cessation, Idiopathic Pulmonary Fibrosis (IPF)
- Trial name
- NCT01776398
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Erectile Dysfunction, Smoking
A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers
Smokers are at higher risk of developing Erectile dysfunction (ED) independent of age and comorbidities. Sildenafil is a cytochrome p3A4 (CYP3A4) substrate used for enhancing the erectile function in males.
- Conditions
- Erectile Dysfunction, Smoking, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT04100759
- Testing
- Sildenafil 50 mg Oral Tablet
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Tobacco Use Disorder, Oral Nicotine Pouch Use
Switching to Potential Reduced Exposure Products in Adult Smokers
This study aims to assess the feasibility, acceptability, and the potential harm reduction of switching to potentially lower risk, oral nicotine pouches in adult smokers.
- Conditions
- Tobacco Use Disorder, Oral Nicotine Pouch Use, Smoking Behaviors, Harm Reduction
- Trial name
- ZYN (NCT04250727)
- Testing
- ZYN
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Lung Cancer
Computer-Assisted Counseling in Helping African American Smokers Stop Smoking
RATIONALE: Stop-smoking plans using a nicotine patch, in-person counseling, and computer-assisted counseling may help people stop smoking.
- Trial name
- NCT00310141
- Testing
- Smoking cessation intervention, Counseling intervention, Nicotine patch
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- M.D. Anderson Cancer Center
Nicotine, Nicotine Vaping
Developing E-liquid Product Standards (Sweet Spot Study)
The Sweet Spot Study aims to evaluate the effect of e-liquids with nicotine varying in freebase (FB) levels and concentrations on the appeal of electronic cigarettes (ECs) in young adult EC users with minimal/no history of…
- Conditions
- Nicotine, Nicotine Vaping, E-cigarette Use
- Trial name
- NCT05864586
- Testing
- Vaping study EC A, Vaping study EC B, Vaping study EC C
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Non-small Cell Lung Cancer
Study of Pralatrexate vs. Erlotinib for Non-Small Cell Lung Cancer After at Least 1 Prior Platinum-based Treatment
The purpose of this clinical study is to determine the effectiveness (ability to provide beneficial treatment of the disease) and safety of pralatrexate compared to erlotinib when given to non-small cell lung cancer (NSCLC)…
- Trial name
- NCT00606502
- Testing
- Pralatrexate, Erlotinib, Vitamin B12
- Where
- 47 sites in United States, Argentina and 4 more
- Volunteers
- 201 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Lung Cancer
Oltipraz in the Prevention of Lung Cancer in People Who Smoke
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. PURPOSE: Randomized phase I trial to study the effectiveness of oltipraz in preventing lung cancer in people who smoke.
- Trial name
- NCT00006457
- Testing
- oltipraz
- Where
- 2 sites in United States
- Sponsor
- Northwestern University
Periodontitis, Cigarette Smoking
The Impact of Cigarette Smoking on Periodontal Therapy
Periodontitis patients, 40 cigarette smokers and 40 non-smokers (defined by cotinine measures in serum), were recruited to this double arm prospective cohort study.
- Trial name
- NCT05120206
- Testing
- Non-surgical periodontal therapy: motivation and instruction in oral hygiene, debridement using handinstrumentation (Hu-Firedy,Chicago, IL, USA;and American Eagle Instruments,Missoula, MT,USA).
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Recession, Gingival, Tissue Grafts
Topical Hyaluronic Acid Adjunctive Effects on Healing After Free Gingival Grafting in Smokers and Non-Smokers
Comparison of the healing of free gingival grafts applied to smokers and non-smokers and evaluation of the effect of hyaluronic acid gel on healing of the donor site.
- Trial name
- NCT07143760
- Testing
- Gengigel
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Healthy Subject, Tobacco Use Disorder
Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers
This randomized clinical trial studies the effects of black raspberry compounds (phytochemicals) on the bacteria in the mouth (oral microbiome) of current smokers and non-smokers.
- Trial name
- NCT02439255
- Testing
- Laboratory Biomarker Analysis, Phytochemical, Screening Questionnaire Administration
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Non Small Cell Lung Cancer, Adenocarcinoma
Intercalated Administration of PamCis With Gefitinib or Placebo as First Line Lung Adenocarcinoma in Never Smokers
Intercalated administration of Iressa® (gefitinib) on days 5-18 of chemotherapy cycle improve the efficacy of Pemetrexed/platinum regimen given as first-line treatment for never-smokers with advanced (stage IIIB/IV) lung…
- Trial name
- NCT01502202
- Testing
- Gefitinib, Pemetrexed plusCIsplatin
- Where
- South Korea
- Volunteers
- 162 people
- Sponsor
- National Cancer Center, Korea
Asthma
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT00576069
- Testing
- budesonide/formoterol, fluticasone/salmeterol, mometasone/formoterol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Gelb, Arthur F., M.D.