Clinical trials: Non-steroidal Anti-inflammatory Drugs
Healthy
Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France
The purpose of this study is to assess in general population NSAID and gastroprotective agent utilization and compliance in elderly people.
- Trial name
- NCT01211652
- Where
- 3,510 sites in France
- Volunteers
- 8,186 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Osteoarthritis, Rheumatoid Arthritis
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501, a fixed-dose combination oral tablet of 800 mg ibuprofen and 26.6 mg famotidine for patients that require long-term NSAID treatment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- NCT00984815
- Testing
- HZT-501
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Pain, Acute, Hip Arthropathy
Safety of Ibuprofen After Major Orthopaedic Surgeries
Safety of an eight-day treatment with ibuprofen after primary hip and knee arthroplasties.
- Conditions
- Pain, Acute, Hip Arthropathy, Knee Arthropathy, Safety Issues
- Trial name
- PERISAFE (NCT05575700)
- Testing
- Ibuprofen
- Where
- 11 sites in Denmark
- Volunteers
- 2,904 people
- Sponsor
- Naestved Hospital
Post-endodontic Pain
Effect of Submucosal Cryotherapy on Postoperative Endodontic Pain
The goal of this clinical trial is to compare submucosal Cryotherapy with different anti-inflammatory drugs in the reduction of post-endodontic pain in upper premolars with symptomatic irreversible pulpitis.
- Trial name
- NCT06090500
- Testing
- Cryotherapy, Diclofenac sodium, Dexamethasone sodium phosphate
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Operation Site Inflammation, Pain, Postoperative
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar
Clinical and preclinical studies have demonstrated encouraging results of non-steroidal anti-inflammatory drug (NSAID) chronotherapy in the management and treatment of inflammatory diseases such as rheumatoid arthritis.
- Conditions
- Operation Site Inflammation, Pain, Postoperative, Teeth, Impacted
- Trial name
- NCT03789058
- Testing
- Ibuprofen 400 mg
- Where
- Jordan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Heartburn
Esomeprazole And Symptomatic Response In Patients With Or Without An Elevated Risk For Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated GI Damage
The purpose of this study is to compare the treatment effect in patients with upper gastro-intestinal complaints with an elevated risk for NSAID-associated GI-damage to those without an elevated risk for NSAID-associated damage…
- Trial name
- Synchronise (NCT00524329)
- Volunteers
- 1,220 people
- Sponsor
- AstraZeneca
Drug-Related Side Effects and Adverse Reactions
CYP4A11 and CYP4F2 Gene Variants as Makers of Cardiovascular Adverse Events of Non-steroidal Anti-inflammatory Drugs
Randomized, double-blinded, cross-over and placebo controlled clinical trial to evaluate the association between genetic polymorphism of CYP4F2 with cardiovascular adverse effects of non-steroidal anti-inflammatory drugs…
- Trial name
- NCT02779530
- Testing
- Diclofenac
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eduardo Barbosa Coelho
Pain
Comparison of Pain Sensation During Single Use of Two Topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Different case reports are showing that depending on the drug used for eye drops, it might provoke a painful sensation. Actually two leading NSAIDs are used in ophthalmology.
- Trial name
- NCT00869219
- Testing
- Nevanac, Acular LS
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Santa Casa de Misericordia de Santos
Rheumatic Arthritis
Capability of Tofacitinib or Etanercept to Accelerate Tapering of NSAID and Treat-to-target Guided De-escalation of Corticosteroids in RA Patients
Patients with active rheumatic arthritis (RA) and lack of efficacy of at least one csDMARD (Disease-modifying anti-rheumatic drug) treatment will be randomized to receive either Tofacitinib (TOFA) or etanercept (ETA).
- Trial name
- AcceleRAte (NCT04485325)
- Testing
- Tofacitinib, Etanercept
- Where
- 6 sites in Germany
- Volunteers
- 92 people
- Sponsor
- Dr. Frank Behrens
Preeclampsia, Gestational Hypertension
Postpartum NSAIDS and Maternal Hypertension
Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period.
- Conditions
- Preeclampsia, Gestational Hypertension, Superimposed Preeclampsia, Chronic Hypertension in Obstetric Context
- Trial name
- NCT03824119
- Testing
- Ibuprofen 600 mg, Standard Postpartum Care without NSAIDs
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Community-acquired Pneumonia
Use of Non Steroidal Antiinflammatory Drugs in Patients With Community Acquired Pneumonia
To investigate exposure to nonsteroidal antiinflammatory drugs (NSAIDs) during outpatient management at the early stage of community-acquired pneumonia (CAP) requiring hospital consultation. Non-interventional observational study.
- Trial name
- ALPAJ (NCT02523885)
- Where
- 4 sites in France
- Volunteers
- 181 people
- Sponsor
- Hôpital Louis Mourier
Ankylosing Spondylitis
Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis
This is a randomised, controlled, multi-centre clinical trial on AS patients. Experimental intervention: continuous (daily) treatment with diclofenac cholestyramine 150 mg (Voltaren Resinate), divided into 75mg Voltaren twice…
- Trial name
- ENRADAS (NCT00715091)
- Testing
- diclophenac
- Where
- 30 sites in Germany
- Volunteers
- 180 people
- Sponsor
- Charite University, Berlin, Germany
Pericarditis Acute
Dexamethasone Compared to Non-steroidal Anti-inflammatory Drugs in the Treatment of Acute Pericarditis
The treatment of acute pericarditis is empiric and is based on treatment with medications with anti-inflammatory properties such as non-steroidal anti-inflammatory drugs (NSAID) and corticosteroids.
- Trial name
- Dexa-P (NCT04323280)
- Testing
- Dexamethasone therapy, NSAID therapy
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Osteoarthritis
Efficacy of Probiotics for NSAID-induced Enteropathy in Arthritis Patients
This study aimed to investigate the efficacy of probiotics as a preventive agent for NSAID-induced enteropathy. Arthritis patients are randomly divided into probiotic and placebo groups, and the drug is administered for eight…
- Trial name
- NSAID (NCT05993247)
- Testing
- Probiotics capsule
- Volunteers
- 36 people
- Sponsor
- Jae Myung Park
Tooth, Impacted, Trismus
Efficacy of Chronoterapy in Oral Surgery
Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus.
- Conditions
- Tooth, Impacted, Trismus, Pain, Inflammatory Response
- Trial name
- ECOS (NCT05126264)
- Testing
- Ibuprofen 400 mg
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Myofascial Pain Syndrome of the Upper Trapezius
Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius: A Pilot Study
Myofascial pain syndrome (MPS) is a common clinical problem of musculoskeletal pain and various treatment modalities have been introduced.
- Trial name
- NCT01884116
- Testing
- NSAID patch, NSAID patch + transcutaneous electric nerve stimulation, NSAID patch + heating pad
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Postoperative Pain, Acute
Pain Treatment With Combinations of NSAIDs
The search for new safe and effective methods of pain relief after surgery on large joints is still an urgent problem. The most optimal approach in the treatment of postoperative pain is the use of multimodal analgesia with a…
- Trial name
- NCT05994287
- Testing
- Aspirin, Ketorolac, Celecoxib
- Where
- Russia
- Volunteers
- 105 people
- Sponsor
- Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
Postoperative Nausea and Vomiting, Surgery
The Application of Transversus Abdominis Plane Block Plus Rectus Sheath Block in Clinical Anesthesia
Peritoneal dialysis (PD) catheter placement surgery for patients with end-stage renal disease (ESRD) can be performed under peripheral nerve block.
- Conditions
- Postoperative Nausea and Vomiting, Surgery, Anesthesia, Peritoneal Dialysis
- Trial name
- NCT02984865
- Testing
- Sulfentanyl, Nalbuphine, flubiprofen axetil
- Where
- China
- Volunteers
- 190 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Rotator Cuff Tear
The Effect of NSAIDs After a Rotator Cuff Repair Surgery.
The main purpose of the study is to determine the effect of Non-steroidal Anti-inflammatory Drugs (NSAIDs) on the healing process after a rotator cuff repair procedure.
- Trial name
- NCT02153177
- Testing
- Rotator cuff repair, Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole, Hydrocodone/Acetaminophen
- Where
- United States
- Sponsor
- University of Chicago
Aspirin Exacerbated Respiratory Disease, Chronic Rhinitis
Characterisation of the Nasal Microbiome in Patients With N-ERD
Chronic rhinosinusitis (CRS) with (w) and without (s) nasal polyps (NP) in its different shapes is currently affecting up to 16% of the total population of the United States and around 11% of the population in Europe.
- Trial name
- MicroNERD (NCT04375293)
- Testing
- Microbiome swabs
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna