Clinical trials: Non-surgical Periodontal Therapy
Periodontitis, Hypertension
Effect of Non-surgical Periodontal Therapy in Hypertensive Patients With Assessment of Endocan and TNF-α Levels in GCF
There is a strong crossway relationship between periodontitis and hypertension. Hypertension is the most prevalent of cardiovascular diseases and its prevalence is increased by the presence of periodontitis.
- Conditions
- Periodontitis, Hypertension, TNF Alpha, Endocan
- Trial name
- NCT06627192
- Testing
- NSPT, clinical and biochemical assesment
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Atrial Fibrillation, Periodontitis
Impact of Periodontal Therapy on AF Recurrence Post-Ablation in High-Inflammatory Burden Patients
Comparison of Non-Surgical Periodontal Therapy versus Background Periodontal Care in Reducing Atrial Fibrillation Recurrence in Patients with AF and Periodontitis: A Randomized Trial with Two Arms (Background Therapy Group vs.
- Trial name
- NCT06892808
- Testing
- Non-Surgical Periodontal Therapy, Background Periodontal Care
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Xu Liu
Thalassemia Major, Chronic Periodontitis
Periodontal Therapy in Thalassemia Major Patients
The study aims to evaluate the effect of local non surgical periodontal therapy on the systemic pro-inflammatory markers in the β-thalassemia (TM-β) patients with chronic periodontitis and systemically healthy demographically…
- Trial name
- NCT03311243
- Testing
- Non surgical periodontal therapy, Chemical plaque control
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- King Saud University
Periodontal Treatment, Cytokines
Non-surgical Periodontal Treatment and Periostin Levels
Two different studies were planned from the recruited samples. The aim of these studies was to investigate the effect of non-surgical periodontal treatment on the inflammatory markers levels in serum and gingival crevicular fluid…
- Trial name
- NCT05535049
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Periimplantitis
Evaluation of the Efficacy of Different Non-Surgical Peri-implantitis Treatment Approaches
Peri-implant diseases, which are the most common biological complications of dental implants, are inflammatory diseases characterized by soft tissue inflammation and loss of supporting bone tissue in the tissues around the…
- Trial name
- NCT06849856
- Testing
- non-surgical peri-implantitis therapy with airflow device, non-surgical peri-implantitis therapy with titanium curette
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Hacettepe University
Periodontitis, Obstructive Sleep Apnea
Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in OSAS
The main objective of this study is to compare the effect of the non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in…
- Conditions
- Periodontitis, Obstructive Sleep Apnea, OSAS
- Trial name
- OSAS (NCT03268473)
- Testing
- Experimental, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Saliva, Cortisol
Comparison of Saliva Biomarkers in Two Different Geographical Regions of Turkey
Periodontitis is a multifactorial, chronic inflammatory disease caused by many factors such as pathogenic microorganisms, host response, environmental and systemic factors.
- Conditions
- Saliva, Cortisol, Smoking, Tobacco, Periodontal Bone Loss
- Trial name
- NCT06809439
- Testing
- Non-Surgical Intervention, Saliva Collection (Baseline), Probing
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Generalized Aggressive Periodontitis
Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis
Generalized aggressive periodontitis (GAgP) is a distinct type of periodontal disease characterized by rapid loss of attachment and alveolar bone occuring in young individuals.
- Trial name
- NCT03412331
- Testing
- Ultrasonic, Hand Instruments, LED Source
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marmara University
Hemophilia A and B, Periodontitis
Effect of Non-Surgical Periodontal Treatment on Oral Health in Hemophilia Patients
This study aimed to evaluate the effect of non-surgical periodontal treatment (NSPT) on oral health-related quality of life in patients with hemophilia using the Oral Health Impact Profile-14 (OHIP-14) questionnaire.
- Conditions
- Hemophilia A and B, Periodontitis, Hemophilia
- Trial name
- NCT07691437
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Periodontal Diseases, Periodontitis
Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial
The aim of this study is to assess whether and how a mouthwash containing an ingredient that reduces inflammation in combination with a recently developed treatment is more effective at improving advanced gum disease.
- Trial name
- AIRTIM (NCT07203872)
- Testing
- IsoDent Paro Strong (Isodent Ltd. Valtakatu 4 D, 96100 Rovaniemi, Finland) mouthwash
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Polycystic Ovary Syndrome, Gingivitis
Evaluation of the Effect of Non-Surgical Periodontal Treatment in Women With Polycystic Ovary Syndrome
The goal of this clinical trial is to compare women with polycystic ovary syndrome and systemically healthy woman in relation to their gums and gum treatment outcomes as well as to investigate the role of a new biomarker in gum…
- Trial name
- NCT06567132
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Chronic Periodontitis
Effect of Frankincense Extract Gel on Non-Surgical Treatment of Chronic Periodontitis
This study will evaluate the effect of the subgingival application of Frankincense extract gel as an adjunct to scaling and root planning (SRP) in chronic periodontitis.
- Trial name
- NCT05005767
- Testing
- scaling and root planing, Frankincense extract gel natural herbal product
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Periodontitis
Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy
The main treatment of every patient with periodontitis is non-surgical periodontal treatment (NSPT) with the ultimate goal to arrest inflammation.
- Trial name
- NCT05608564
- Testing
- Piperacillin and Tazobactam in gel form, Amoxicillin and Metronidazole
- Where
- Serbia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Periodontitis, Chronic Periodontitis (Disorder)
Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Therapy in Stage II Periodontitis
Gum disease (periodontitis) affects millions of people worldwide and can lead to tooth loss if untreated. The standard treatment is a deep cleaning procedure called non-surgical periodontal therapy (NSPT), where a dentist removes…
- Trial name
- aPDT-NSPT (NCT07609888)
- Testing
- Non-Surgical Periodontal Therapy (NSPT), Antimicrobial Photodynamic Therapy (aPDT) with Indocyanine Green and 810 nm Diode Laser
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Gulf Medical University
Periodontal Pocket, Periodontitis
"Re-instrumentation vs Flap Surgery"
There are no studies comparing reinstrumentation and flap surgery for the treatment of residual periodontal pockets. The aim of this RCT is to compare the re-instrumentation vs the flap surgery in terms of PD reduction, CAL gain…
- Trial name
- NCT05460988
- Testing
- Flap surgery, Non surgical re-instrumentation
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- University of Florence
Smoking ( Cigarette), Periodontitis Stage II
Study of Gum Tissue Proteins in Smokers vs. Non-smokers After Cleaning
The aim of this study is to evaluate how smoking affects the healing process of the gums after treatment. The researchers will measure the levels of two specific proteins (PLAP-1 and Sclerostin) in the gum fluid of patients with…
- Trial name
- NCT07339670
- Testing
- Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%)
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Al-Azhar University
Periodontitis
Clinical and Immunological Evaluation of HA in Treatment of Periodontitis
To evaluate the immunological effectiveness of Hyaluronic acid as adjunction treatment to scaling and root planning and scaling and root planning alone. Comparison between clinical measurement before and after treatment.
- Trial name
- NCT06324474
- Testing
- Hyaluronic acid, scaling and root planning
- Where
- Yemen
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sana'a University
Peri-implantitis
Long-term Follow-up Observation After Surgical Treatment of Peri-implantitis in Multicenter Post Market Clinical Study
The objective of this non-interventional long-term follow-up observation is to evaluate the long-term sustainability of two surgical treatments of peri-implantitis with and without Geistlich Bio-Oss® and Geistlich Bio-Gide® from…
- Trial name
- NCT03776097
- Testing
- observational study
- Where
- Sweden
- Volunteers
- 59 people
- Sponsor
- Geistlich Pharma AG
Aggressive Periodontitis, Generalized, Periodontal Health
GCF HIF-1α, VEGF and TNF-α Levels in G-AgP Patients Before and After Periodontal Treatment.
Hypoxia-inducible angiogenic pathway involving hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumour necrosis factor- alpha (TNF-α) may regulate the several biological processes related…
- Trial name
- NCT04020315
- Testing
- Non-surgically performed scaling and root planing
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Obesity, Periodontitis
Chemerin and Interleukin-6 Levels of Gingival Crevicular Fluid in Obese Individuals Following Periodontal Treatment
The objective in this case-control intervention study, therefore, was to explore the effect of nonsurgical periodontal therapy on the GCF levels of chemerin and IL-6 in patients with chronic periodontitis in order to determine…
- Trial name
- NCT02660814
- Testing
- Non-surgical periodontal treatment, Gingival crevicular fluid collection
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Umut BALLI