Clinical trials: Non-surgical Periodontal Therapy
Periodontitis
Use of Laser Assisted New Attachment Procedure and Low Level Laser Therapy for Periodontitis Patients
In this study, it is evaluated the effects of laser assisted new attachment procedure (LANAP) and low level laser therapy (LLLT) and on clinical, biochemical and radiographic parameters in addition to non-surgical periodontal…
- Trial name
- LANAP LLLT (NCT04694222)
- Testing
- Nd:YAG laser
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Periodontitis
Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours
Periodontitis is a form of gum disease that affects many people in the world. Its traditional protocol of treatment includes oral hygiene instruction and dental scaling to remove debris, dental plaque and tartar in 4 weekly…
- Trial name
- NCT02215460
- Testing
- FMS full-mouth scaling, QS quadrant scaling, FMS chlorhexidine rinse
- Where
- Brazil
- Volunteers
- 130 people
- Sponsor
- University of Taubate
Chronic Periodontitis, Cardiovascular Diseases
NSPT On Vitronectin And Fetuin-A Levels In Patients With Periodontitis And Coronary Artery Disease
Periodontitis is a chronic inflammatory disease mainly caused by the oral microbial biofilm. It involves the periodontal supporting tissues mainly features gum inflammation, alveolar bone resorption, periodontal pocket formation…
- Conditions
- Chronic Periodontitis, Cardiovascular Diseases, Periodontal Inflammation
- Trial name
- NCT05663476
- Testing
- Non Surgical Periodontal Therapy
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Chronic Periodontitis, Chronic Periodontitis Wth Diabetes Mellitus
Metabolic Regeneration Registry for Periodontal Health (20-Patient Cohort).
This observational study documents the clinical outcomes of a proprietary, safe-to-swallow metabolic protocol for chronic gum disease.
- Conditions
- Chronic Periodontitis, Chronic Periodontitis Wth Diabetes Mellitus, Non-surgical Periodontal Treatment, Gingival Regeneration
- Trial name
- NCT07538661
- Testing
- Nutraceutical Bio-Active Oral Repair Formula (Food-Grade), Nutraceutical Bio-Active Oral Repair Formula
- Where
- Algeria
- Volunteers
- 20 people
- Sponsor
- Amar h Zireg
Non Surgical Periodontal Treatment, Periodontitis
Influence of Environmental Factors on the Efficacy of Non-surgical Periodontal Treatment. A Pre-post Quasi-experimental Study
Periodontitis is a biofilm-mediated chronic inflammatory disease which causes the destruction of the supporting tissues of the tooth.
- Conditions
- Non Surgical Periodontal Treatment, Periodontitis, Periodontal Diseases
- Trial name
- NCT04769622
- Testing
- Non-surgical periodontal treatment, Questionnaires
- Where
- Italy
- Volunteers
- 125 people
- Sponsor
- University of Siena
Chronic Periodontitis, Clinical and Microbiological Effects
Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis.
Background: Peridontitis is a group of diseases with complex bacterial etiology that affects a large proportion of the Chilean and worldwide population.
- Trial name
- Metro + Amoxi (NCT01211223)
- Testing
- Administration of Metronidazole plus Amoxicillin
- Where
- Chile
- Volunteers
- 42 people
- Sponsor
- University of Chile
Type 2 Diabetes Mellitus, Periodontal Disease
The Effect of Non-Surgical Periodontal Therapy on Glycemic Control and Bacterial Levels in a Mexican-American Population With Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) has become a significant pandemic with more than 7% of the population in the United States affected.
- Trial name
- NCT01128374
- Testing
- Periodontal Scaling and root planing
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- The University of Texas Health Science Center, Houston
Periodontitis, Pocket, Periodontal
Diode Laser as an Adjunct to Professional Mechanical Plaque Removal
This study will utilize diode laser to determine its effects on improving periodontal parameters and inflammatory biomarkers, comparing with conventional treatment alone, and evaluate its effectiveness in improving periodontal…
- Trial name
- NCT06719674
- Testing
- Professional mechanical plaque removal and Laser, Professional mechanical plaque removal
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- University of Sulaimani
Periodontal Diseases, Local Anesthesia
The Anesthetic Effect of Anterior Middle Superior Alveolar Technique
Anesthesia of the soft and hard tissues in the maxilla may require up to five injections. Thus, the aim of the present study was to evaluate the anesthetic efficacy in buccal tissues after the use of the anterior middle superior…
- Conditions
- Periodontal Diseases, Local Anesthesia, Pain
- Trial name
- NCT01742559
- Testing
- Anterior middle superior alveolar, Supraperiosteal technique
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- State University of Maringá
Diabete Type 2, Apical Periodontitis
Effect of Primary Non-surgical Endodontic Therapy on Glycaemic Control in Type 2 Diabetic Patients With Asymptomatic Apical Periodontitis
To evaluate the effect of primary non-surgical endodontic therapy on glycaemic control in type 2 diabetic patients with asymptomatic apical periodontitis.After fulfilling the eligibility criteria, patients will be informed about…
- Trial name
- NCT05170880
- Testing
- Primary endodontic treatment
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Stress, Psychological, Periodontal Diseases
Effect of Stress on Periodontal Therapy (NPT)
Aim of this study: is to evaluate the influence of stress level on the response of non surgical periodontal therapy in patients affected by severe periodontitis divided into "Medium/High stress level" or "Low stress level" based…
- Conditions
- Stress, Psychological, Periodontal Diseases, Periodontitis, Non Surgical Periodontal Therapy
- Trial name
- NCT04739475
- Testing
- Non Surgical Periodontal Therapy
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- University of Turin, Italy
Generalized Aggressive Periodontitis
Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment
This study is designed as a parallel, masked, randomized, placebo-controlled clinical trial to assess the clinical, microbiological, and immunological outcomes of scaling and root planning (SRP) or full-mouth ultrasonic…
- Trial name
- NCT03933501
- Testing
- amoxicillin and metronidazole
- Volunteers
- 48 people
- Sponsor
- University of Campinas, Brazil
Sphingosine 1-phosphate, Interleukin 1-beta
IL-1β and S1P Levels After Periodontal Therapy: A Split-Mouth Study
This randomized split-mouth clinical trial aimed to evaluate the changes in interleukin-1 beta (IL-1β) and sphingosine-1-phosphate (S1P) levels in gingival crevicular fluid (GCF) following non-surgical periodontal therapy (NSPT)…
- Conditions
- Sphingosine 1-phosphate, Interleukin 1-beta, Gingival Crevicular Fluid, Non-surgical Periodontal Therapy
- Trial name
- NCT06930430
- Testing
- Non-Surgical Periodontal Therapy (NSPT)
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Peri-implant Mucositis, Peri-Implantitis
Peri-implant Phenotype, Calprotectin and Mmp-8 Levels in Cases Diagnosed With Peri-implant Disease
Following the implantation procedures; The peri-implant mucosa may begin to show signs of inflammation depending on the patient (bruxism, lack of oral hygiene) or other factors (planning errors, iatrogenic factors).
- Trial name
- NCT06173739
- Testing
- Non-surgical mechanical treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Beliz Önder
Arthritis, Rheumatoid, Periodontitis
Periodontal Therapy in Patients With Rheumatoid Arthritis
Aim: A prospective randomized, controlled clinical trial comparing two groups of a cohort of Rheumatoid Arthritis (RA) patients with periodontal disease will be carried out to identify if the effect of non-surgical periodontal…
- Trial name
- NCT05502601
- Testing
- Non-surgical periodontal treatment
- Where
- Peru
- Volunteers
- 42 people
- Sponsor
- Federal University of Rio Grande do Sul
Periodontal Diseases, Smoking Cessation
Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy
The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease.
- Trial name
- NCT06145685
- Testing
- Minimally invasive non-surgical periodontal therapy, Conventional non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Periodontitis
L-PRF Plus Non Surgical Periodontal Treatment
Abstract: Background: Leucocyte and Platelet-Rich Fibrin (L-PRF) has shown to promote regenerative processes, even reporting antibacterial effect.
- Trial name
- NCT04520438
- Testing
- Leukocyte and platelet rich fibrin, Non-Surgical Periodontal treatment
- Where
- Chile
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Ozone-therapy (O3), Periodontitis
Ozone-therapy in Non-surgical Periodontal Therapy
Non-surgical periodontal therapy is a widely adopted procedure for the treatment of periodontitis, particularly in its moderate to severe stages.
- Conditions
- Ozone-therapy (O3), Periodontitis, Antimicrobial Ozone Therapy
- Trial name
- PD-OZONE (NCT07202312)
- Testing
- Ozone-therapy after non-surgical therapy
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Periodontal Diseases, Smoking
Effect of Smoking on Periodontal Therapy in Periodontitis
The present study aimed to assess the effect of smoking on non-surgical periodontal treatment on serum and salivary RANKL, OPG and IL34 levels in periodontitis stage III grade C (P-III-C) patients.
- Trial name
- NCT05262153
- Testing
- Non-surgically performed scaling and root planing
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontal Diseases, Dental Diseases
Instrumentation Effectiveness of Modified, Area-Specific Hand Scalers During Non-Surgical Periodontal Therapy
The goal of this project is to analyze the effectiveness of calculus and biofilm removal using area-specific hand scalers such as Mini Five® Gracey Curettes and Micro Mini Five® Gracey Curettes in periodontal pockets that are 5mm…
- Trial name
- NCT03729167
- Testing
- Scaling and root planing
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Michigan