Clinical trials: Non-traumatic Brain Injury
Traumatic and/or Non-traumatic Brain Injury
Assessing Special Features of Impaired Gait After Acquired Brain Injury With an Instrumented Treadmill
Hemiparetic gait following acquired brain injury (ABI) is grossly characterized by decreased speed of walking, increased stance time on the unaffected side, and decreased stance time on the affected side.These abnormalities are…
- Trial name
- NCT01413321
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Brain Electrical Impedance;, Non-invasive Intracranial Pressure
Comparison of the Application in Traumatic Brain Edema Between EIT and Non-invasive ICP Monitoring
Brain edema is the main reason for the disability and lethality in traumatic brain injury, which is the most difficult part of emergency rescue. Recently, there is no medical equipment to monitor the early brain edema in clinic.
- Trial name
- EIT (NCT02027857)
- Testing
- EIT monitoring, non-invasive ICP monitoring
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
PTSD, Post Traumatic Stress Disorder
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
The investigators want to test a treatment for posttraumatic stress disorder (PTSD) especially designed for military veterans and service members with mild or moderate traumatic brain injuries (TBI) and PTSD.
- Conditions
- PTSD, Post Traumatic Stress Disorder, Traumatic Brain Injury
- Trial name
- T3 for PTSD (NCT07351305)
- Testing
- Non-Trauma Treatment for TBI and PTSD
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Craniocerebral Trauma, Facial Injuries
Financial and Clinical Impact of Repeal of the Pennsylvania Motorcycle Helmet Law
The purpose of this study is to find out how many helmeted versus non-helmeted motorcycle accident victims (MCA) sustain head and/or face injuries.
- Trial name
- NCT00200135
- Where
- 2 sites in United States
- Volunteers
- 480 people
- Sponsor
- Memorial Medical Center
Traumatic Brain Injury
Crainio Non-invasive ICP Monitor for TBI
The clinical investigation aims to advance the Crainio device, designed for non-invasive intracranial pressure (ICP) monitoring.
- Trial name
- NCT06453733
- Testing
- Crainio
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Crainio Ltda
Traumatic Brain Injury (TBI), Subarachnoid Hemorrhage (SAH)
Non-invasive Brain Pressure Monitoring After Trauma or Hemorrhage
Introduction: Increased intracranial pressure (ICP) is considered to be the most important intracranial mechanism causing secondary injury in patients admitted after acute traumatic brain injury (TBI) and intracranial haemorrhage…
- Trial name
- NCT02172703
- Testing
- Non-invasive ICP measurement device
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Javier Fandino, MD
Seizures, Subdural Hematoma
Diagnostic Subdural EEG-electrode And Subdural hEmatoma (DISEASE)
Epileptic seizures are one of the frequent complications in patients with traumatic brain injury; the incidence lies approximately at 20%.
- Trial name
- NCT04211233
- Testing
- invasive subdural grid electrode, Control arm
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Clinic Frankfurt
Aphasia, Apraxia of Speech
taVNS for Speech and Language Recovery in Aphasia
The goal of this research study is to evaluate a novel approach to improving speech recovery in those with acquired apraxia of speech.
- Trial name
- NCT07563387
- Testing
- taVNS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Anxiety Disorders and Symptoms, Sensory Disorders
Assessing the Clinical Utility of tACS
The present study seeks to evaluate the clinical utility of repeated transcranial alternating current stimulation (tACS) by assessing long-term, lasting changes in oscillatory activity and subsequent changes in related behavioral…
- Conditions
- Anxiety Disorders and Symptoms, Sensory Disorders, Hypervigilance, Post Traumatic Stress Disorder
- Trial name
- NCT03305328
- Testing
- Transcranial Alternating Current Stimulation
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Florida State University
Traumatic Brain Injury
A Study to Test the SENSE Device in Military-Age Patients With Traumatic Brain Injury
The study population will consist of 3 mutually-exclusive sets of patients and subjects: TBI patients with intracranial bleeding TBI patients without intracranial bleeding Control subjects with normal brain health.
- Trial name
- Sense-005 (NCT05155800)
- Testing
- SDx3
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sense Diagnostics, LLC
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC
Brain Injuries, Hyperglycemia
Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury
An increase in blood glucose is a common clinical symptom in patients following traumatic brain injury. Studies confirm that death after traumatic brain injury was not only associated with nerve injury, but also correlated with…
- Trial name
- NCT02161055
- Testing
- Insulin
- Where
- 2 sites in China
- Volunteers
- 144 people
- Sponsor
- Lianyungang Oriental Hospital
Brain Concussion
Control Study of Nautilus BrainPulse for the Detection of Concussion
To use the Nautilus BrainPulse to compare and contrast the signal patterns from this cohort's signal patterns with those of concussed high school athletes.
- Trial name
- NCT02350699
- Testing
- Nautilus BrainPulse
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Head Injuries With Non Missile Penetrating Objjects
Non-missile Penetrating Head Trauma,Cases Registry in Sohag University Hospital
A retrospective study was done in Neurosurgery trauma unit, Sohag University. Eighteen patients reported with different mechanisms of trauma. All patients clinically tested involving neurological evaluation.
- Trial name
- trauma (NCT03768778)
- Testing
- Debridement and dural repair
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sohag University
Stroke, Traumatic Brain Injury
Daily Light Exposure for Sleep Disturbance, Fatigue, and Functional Outcomes in Acute Brain Injury
The purpose of this study is to assess the safety and efficacy of daily morning exposure to colored light in patients receiving acute inpatient rehabilitation services for stroke, traumatic brain injury, or non-traumatic brain…
- Conditions
- Stroke, Traumatic Brain Injury, Non-traumatic Brain Injury
- Trial name
- NCT03125967
- Testing
- Philips GoLite Blu HF3429/60, Philips LivingColor Aura 70998/60/48
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- St. Luke's Rehabilitation Institute
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
PTSD, Post Traumatic Stress Disorder PTSD
Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)
The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in…
- Conditions
- PTSD, Post Traumatic Stress Disorder PTSD, PTSD - Post Traumatic Stress Disorder, Post Traumatic Stress Disorder
- Trial name
- NCT07523685
- Testing
- non-invasive vagus nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Acacia Clinics
Brain Injuries, Traumatic, Right Hemispheric Stroke
Therapy of Pragmatic Disorders in Brain-damaged Individuals
This study aims to assess speech therapy's effectiveness in understanding other people's thoughts (implied) using written stories.
- Trial name
- NCT04708561
- Testing
- Speech and language therapy
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- University of Neuchatel
Brain Injuries, Traumatic
Non-Invasive Monitoring of Traumatic Brain Injury Progression Using the Infrascanner (MOBI-1)
MOBI-1 is a multicenter clinical trial that will evaluate the use of the Infrascanner for the monitoring of traumatic intracranial hematomas.
- Trial name
- MOBI-1 (NCT04893837)
- Testing
- Standard care plus infrascans
- Where
- 2 sites in United States
- Volunteers
- 399 people
- Sponsor
- University of Alabama at Birmingham