Clinical trials: Nonalcoholic Fatty Liver
Metabolic Dysfunction-Associated SteatoHepatitis (MASH)
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
This study is researching an investigational drug, ALN-HSD called "study drug". This study is focused on participants who are known to have Metabolic dysfunction-Associated SteatoHepatitis (MASH).
- Trial name
- NASHGEN-2 (NCT05519475)
- Testing
- ALN-HSD
- Where
- 71 sites in United States, Japan and 2 more
- Volunteers
- 120 people
- Sponsor
- Regeneron Pharmaceuticals
Non-Alcoholic Fatty Liver Disease
Safety and Efficacy of Hoodia Gordonii for Treatment of Non Alcoholic Fatty Liver Disease (NAFLD)
This clinical study is designed to evaluate the safety of oral administration of the medical food Hoodia to patients with non alcoholic fatty liver disease.
- Trial name
- NCT00816465
- Testing
- Hoodia gordonii
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Psoriatic Arthritis
Elucidating Shared Mechanisms Contributing to NAFLD and PsA Disease Severity With Guselkumab Therapy
While many studies examine Nonalcoholic fatty liver disease (NAFLD), little is known about its progression to high-risk nonalcoholic steatohepatitis (NASH) in PsA patients.
- Trial name
- NCT06586281
- Testing
- Guselkumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
NAFLD
NAFLD in Patient of Hypothyroidism
Nonalcoholic fatty liver disease (NAFLD) is the most important chronic liver disease in the western world, affecting almost 30% of the general population.
- Trial name
- NCT05813301
- Volunteers
- 100 people
- Sponsor
- Assiut University
NASH - Nonalcoholic Steatohepatitis
Non Alcoholic Steatohepatitis in Relation to Visceral and Subcutaneous Fat
Evaluate the relationship between the severity of fatty liver in NAFLD assessed by ultrasonography and CT and the visceral fat area measured by CT
- Trial name
- NCT04240145
- Testing
- MSCT Abdomen
- Volunteers
- 35 people
- Sponsor
- Gehad Abd Elaziz Mhmoud Ahmad
Non Alcoholic Fatty Liver Disease
The Effect of Oral β- Glucan Supplement on Appetite and Insulin Resistance in Non Alcoholic Fatty Liver Disease
The Objective of This Study is Evaluating the Effect of oral β- glucan Supplement on Anthropometric Measurements, Appetite, Insulin Resistance, Liver echogenicity and Enzymes in Non Alcoholic Fatty Liver Patients Treating with…
- Trial name
- NCT02178839
- Testing
- β- glucan, Maltodextrin
- Where
- Iran
- Volunteers
- 48 people
- Sponsor
- Urmia University of Medical Sciences
NAFLD, Non-alcoholic Fatty Liver Disease
Comparing Effects of Beetroot Juice and Mediterranean Diet on Liver Enzymes and Sonography in Patients With NAFLD
The goal of this clinical trial study is to investigate comparing Effects of Beetroot juice and Mediterranean diet on Liver Enzymes and Sonographic appearance in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) The main…
- Trial name
- BJ (NCT05909631)
- Testing
- Beetroot juice, Mediterranean diet alone (MeD), Mediterranean diet with beet juice (BJ+MeD)
- Where
- Iraq
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Sulaimani Polytechnic University
NAFLD, NASH - Nonalcoholic Steatohepatitis
Quantifying Body Composition and Liver Disease in Children Using Free-Breathing MRI and MRE
Magnetic resonance imaging (MRI) is used to measure liver fat content and fatty tissues in the body, and magnetic resonance elastography (MRE) is used to measure liver stiffness.
- Trial name
- NCT04591106
- Testing
- Magnetic resonance imaging (MRI), Magnetic resonance elastography (MRE), Prototype MRE soft flexible passive transducer paddle
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Nonalcoholic Fatty Liver Disease, Coronary Artery Disease
The Contribution of Lp-PLA2 Level to the Presence of Coronary Plaques in Patients With Non Alcoholic Fatty Liver Disease
The most common cause of death in patients with NAFLD(Nonalcoholic Fatty Liver Disease) is CAD(Coronary Artery Disease). NAFLD patients have 65% more mortality than general population.
- Trial name
- 0030-10 (NCT01139632)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Ziv Hospital
Liver Disease
Nonalcoholic Fatty Liver Disease (NAFLD) Adult Database 2
The NAFLD Database 2 will recruit at least 1,500 new adult participants suspected or known to have NAFLD or nonalcoholic steatohepatitis (NASH)-related cirrhosis and will also invite adult participants from the prior NAFLD…
- Trial name
- NCT01030484
- Where
- 8 sites in United States
- Volunteers
- 2,501 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diabetes Mellitus, Type 2, Hypertriglyceridemia
MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia
The design of the Phase 2 clinical trial includes the following elements: Multi-center, two-arm, randomized, double-blind, placebo-controlled trial to evaluate MN-001 (tipelukast) vs.
- Conditions
- Diabetes Mellitus, Type 2, Hypertriglyceridemia, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT05464784
- Testing
- MN-001
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- MediciNova
Fatty Liver Disease, Obesity
Effect of Lyophilized Cornus Mas L. on Anthropometric and Biochemical Parameters in Metabolic Associated Fatty Liver Disease Patients
The aim of the study was to evaluate the effect of lyophilized Cornus mas L. fruit powder with/without diet therapy on biochemical parameters and anthropometric measurements in patients with metabolic associated fatty liver…
- Conditions
- Fatty Liver Disease, Obesity, Liver Fat
- Trial name
- NCT05546450
- Testing
- Diet, Cornus mas L.(Cornelian Cherry)
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Istanbul Gelisim University
Fatty Liver, Obesity
Study of the Efficacy and Safety of Nicotinamide in Patients With Liver Fibrosis (NICOFIB)
The objective of this clinical trial, a pilot study, is to assess the impact of nicotinamide (NAM) on individuals with hepatic fibrosis.
- Conditions
- Fatty Liver, Obesity, Hepatic Fibrosis, NAFLD
- Trial name
- NICOFIB (NCT06599918)
- Testing
- Nicotinamide
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
NASH
A Clinical Trial of BGT-002 Tablets in Subjects With Nonalcoholic Steatohepatitis
This study is a single-center, randomized, double-blind, multiple ascending doses (MAD), placebo-controlled phase Ib/IIa clinical trial of BGT-002 Tablets in subjects with NASH to evaluate the safety, tolerability…
- Trial name
- NCT06491576
- Testing
- BGT-002
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Burgeon Therapeutics Co., Ltd.
Patients With Nonalcoholic Steatohepatitis
Evaluate the Efficacy, Safety and Tolerability of Fecal Microbiota Transfer for the Treatment of Patients With Nonalcoholic Steatohepatitis
The EMOTION study is a multicentric, double-blind, controlled, parallel-group, phase IIa randomized Clinical trial to evaluate the efficacy, safety and tolerability of TMF capsules for the treatment of patients with NASH.
- Trial name
- EMOTION (NCT05622526)
- Testing
- Group 1 or Experimental group, Group 2 or Control group
- Volunteers
- 96 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Dyslipidemia, Diabetes
Meta-analyses of Fructose and Cardiometabolic Risk
Diabetes and heart associations continue to discourage high intakes of dietary fructose, a constituent part of the sucrose molecule that is found in fruits and vegetables as a natural sugar and in some processed foods and…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01363791
- Testing
- Dietary fructose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Obesity, Diabetes
Raspberry Ketone Intake Upregulates Circulating FGF21 and Induces Energy Expenditure in Humans
To investigate the molecular mechanism of raspberry ketone on regulating obesity, the investigators studied the effect of raspberry ketone intake on FGF21 in plasma.
- Conditions
- Obesity, Diabetes, NAFLD (Nonalcoholic Fatty Liver Disease)
- Trial name
- NCT06681597
- Testing
- Raspberry ketone
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanchang University
Fatty Liver
A Prospective, Randomized Trial to Compare saroGLitazar With pioglitAZone in Nonalcoholic Fatty livEr Disease
Non Alcoholic Fatty Liver Disease (NAFLD) is considered as the component of metabolic syndrome. The prevalence of the same has been increasing rapidly in India, along with an increase in the prevalence of diabetes and obesity.
- Trial name
- GLAZED (NCT02265276)
- Testing
- Saroglitazar, Pioglitazone
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Command Hospital, India
Morbid Obesity, Type2diabetes
Comorbidities Resolution After MGB Surgery and Change in Body Composition
This observational study aims to learn about the correlation between the improving comorbidities associated with obesity after MGB (Mini-Gastric Bypass) surgery and changes in body composition in morbidly obese patients.
- Conditions
- Morbid Obesity, Type2diabetes, Sleep Apnea, Hypothyroidism
- Trial name
- MOGAMBO (NCT06015620)
- Testing
- Mini gastric bypass surgery
- Where
- India
- Volunteers
- 35 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Non-Alcoholic Fatty Liver Disease
Effects of Time-restricted Hypocaloric Diet in Patients with NAFLD
The effects of a time-restricted hypocaloric Mediterranean type diet compared to a conventional hypocaloric Mediterranean type diet on blood glucose metabolism and liver steatosis in people with non-alcoholic fatty liver disease…
- Trial name
- NCT05866744
- Testing
- Early Time-Restricted Feeding Plus Hypocaloric Mediterranean Diet, Late Time-Restricted Feeding Plus Hypocaloric Mediterranean Diet, Hypocaloric Mediterranean Diet Without Time Restriction In Feeding
- Where
- 2 sites in Greece
- Volunteers
- 59 people
- Sponsor
- Agricultural University of Athens
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