Clinical trials: Nonunion Fracture
Nonunion Fracture
The Efficacy of Mesenchymal Stem Cells for Stimulate the Union in Treatment of Non-united Tibial and Femoral Fractures in Shahid Kamyab Hospital
Because the rate of non union of long bone in lower extremities specially in tibia in this two last decade due to malnutrition and smoking and other risk factors was increased, so many patient in our country suffer from non union…
- Trial name
- NCT01788059
- Testing
- injection the mesenchymal stem cell in non union site
- Where
- Iran
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Emdadi Kamyab Hospital
Femur Fracture, Tibial Fractures
Distal Targeter vs Free-hand
This study is a randomized controlled trial comparing the use of two different surgical techniques--free-hand versus distal targeting jig-based for distal interlock screw--placement and their effects on total operative time and…
- Conditions
- Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia
- Trial name
- NCT05613257
- Testing
- Distal targeting jig, Free-hand/perfect circles technique
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Cedars-Sinai Medical Center
Atrophic Nonunion of Fracture
Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones
The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in non-union fractures (pseudoarthrosis) of long bones in comparison to the standard treatment of autologous iliac crest.
- Trial name
- NCT02230514
- Testing
- XCEL-MT-OSTEO-ALPHA, autologous iliac crest, Surgery
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Banc de Sang i Teixits
Pseudarthrosis, Fractures, Ununited
Treatment of Atrophic Nonunion by Preosteoblast Cells
Treatment of nonunion, delayed union and malunion fractures of long bones remains problematic. The definition of nonunion is a failure of the fracture to heal in six months in a patient in whom progressive repair had not been…
- Trial name
- NCT00916981
- Testing
- percutaneous autologous preosteoblast cells implantation
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Jean-Philippe Hauzeur
Rheumatoid Arthritis, Osteoarthritis
A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the Pinnacle™ Cup with a polyethylene-on-metal bearing combination in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00208429
- Testing
- Pinnacle Acetabular System
- Sponsor
- DePuy International
Tibia Fracture
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures
The proposed study is a two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial. 1,000 patients with tibia fractures treated with intramedullary (IM) nail will be randomized into two treatment arms.
- Trial name
- NCT05000281
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Fracture Non Union, Infection
Antibiotic Loaded Calcium Sulfate RCT
This is a multi-centered, prospective, randomized controlled trial comparing current standard of care for defect management to placement of antibiotic loaded Stimulan as a bone void filler in patients undergoing treatment of…
- Trial name
- NCT03875963
- Testing
- Antibiotic loaded bone filler
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Rib Fracture
Evaluation of Surgical Treatment on Pain and Disability for Chronic, Non-healing Rib Fracture
Individuals with non-healing rib fractures may experience significant pain and disability. This is called rib fracture non-union, an unusual problem and one that most physicians have little experience with.
- Trial name
- NCT00774618
- Testing
- Resection with or without plate fixation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Oregon Health and Science University
Nonunion Fracture
Allograft vs. Autograft Nonunion
The purpose of this research study is to find out if patients treated for nonunion fracture with autograft or allograft return to activity faster.
- Trial name
- NCT07310082
- Testing
- Autograft, Allograft
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Wake Forest University Health Sciences
Neck Injuries, Spinal Injuries
Treatment of Type II Odontoid Fractures Among the Elderly
The purpose of this study is to compare the safety and effectiveness of surgical versus conservative management of type II odontoid fractures among patients > 64 years of age.
- Trial name
- NCT00266929
- Testing
- surgical, conservative treatment
- Where
- 15 sites in United States, Canada
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- AOSpine North America Research Network
Rheumatoid Arthritis, Osteoarthritis
G7 BiSpherical Acetabular Shell PMCF Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available G7 BiSpherical Acetabular Shell.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis
- Trial name
- NCT03266874
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 160 people
- Sponsor
- Zimmer Biomet
Fracture Non Union
Validity of the Non-union Scoring System in Management of Long Bone Fracture Non-union
The aim of this study is to apply Calori Non union Scoring System on long bone non-union cases and evaluate the results of treatment o f the patients according to the score.
- Trial name
- NCT07207447
- Testing
- Improving the stability and re-fixation with different modalities, Re-fixation with biological stimulation, complex care with non-union resection and bone reconstruction
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Pseudoarthrosis of Bone, Pseudarthrosis
Treatment of Nonunion Fractures With Mesenchymal Stromal Cells (MSCs)
The goal of this study is to evaluate the bone regeneration capacity of BM-MSC (Bone marrow mesenchymal stromal cells), in patients with nonunion.
- Conditions
- Pseudoarthrosis of Bone, Pseudarthrosis, Non Union Fracture, Nonunion Bone Fracture
- Trial name
- MSC (NCT06103396)
- Testing
- Transplantation of autologous MSCs in nonunion fracture, Transplantation of allogeneic MSCs in nonunion fracture
- Where
- Venezuela
- Volunteers
- 30 people
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Fractures, Bone, Nonunion of Fracture
Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care
Prospective registry and retrospective data collection study to assess the efficacy and safety of Vivigen Cellular Bone Matrix (Vivigen) in orthopaedic trauma patients who require bone grafting in the acute, delayed, non-union…
- Conditions
- Fractures, Bone, Nonunion of Fracture, Fractures, Open, Fractures, Ununited
- Trial name
- NCT04299022
- Testing
- Vivigen Cellular Bone Matrix
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- LifeNet Health
Fracture Non Union
Results of the Staged Surgical Approach for Management of Infected Un-united Femoral Shaft Fractures in Adults
Assessment of the efficacy of the multistage technique in the eradication of infection and achieving the union of traumatic infected femoral un-united shaft fractures in adult patients for one year follow up.
- Trial name
- NCT04681846
- Testing
- Staged approach using antibiotic-cement impregnated PMMA spacer
- Volunteers
- 40 people
- Sponsor
- Assiut University
Nonunion of Fracture
NGS for Non-unions
The purpose of this study is to investigate the role of genetic testing to look for possible infection as a cause for failure of non-healing fractures.
- Trial name
- NCT03937310
- Testing
- Next-generation sequencing of swabs collected during surgery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rothman Institute Orthopaedics
Orthopedic
Long-term Surgical Outcomes of Scaphoid Proximal Pole Fracture Nonunion
The treatment for scaphoid proximal pole nonunion remains challenging due to the poor vascularity in the proximal pole fragment, associated SL injury and the technique of fixation.
- Trial name
- NCT03701269
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Non-union or Delayed Healing Fractures
Evaluation of the Risk for Radiographic and Clinical Nonunion in Patients With Previous Bisphosphonates Therapy.
Dose and duration of bisphosphonate therapy will increase the likelihood that patients experience delayed healing of non-union fractures.
- Trial name
- NCT01731535
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Proximal Humeral Fracture, Fracture Dislocation
Exactech Proximal Humerus Fracture Plate System Post Market Clinical Follow-up
The objective of this study is to collect and evaluate long-term clinical outcomes data in order to better understand the safety and performance of the Equinoxe Proximal Humerus Fracture Plates over time.
- Conditions
- Proximal Humeral Fracture, Fracture Dislocation, Non-Union Fracture
- Trial name
- NCT05703958
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Exactech