Clinical trials: Norepinephrine
Septic Shock, Cardiomyopathy
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock…
- Trial name
- SCLM (NCT02640846)
- Testing
- Norepinephrine, Milrinone, Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Spinal Anesthesia Induced Hypotension
COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial
The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension.
- Trial name
- NCT06836986
- Testing
- Norepinephrine Bolus, Phenylephrine bolus
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Dow University of Health Sciences
Alzheimer Disease
Implantable Vagus Nerve Stimulation Modulation of Coeruleus-Norepinephrine Network for Mild-Moderate AD Patients
A randomized controlled clinical study will be conducted in Xuanwu Hospital of Capital Medical University. This study initially explore the effect of selective vagus nerve(C fiber) stimulation on mild-to-moderate AD patients, in…
- Trial name
- NCT05575271
- Testing
- Vagus Nerve Stimulation Modulation of the Coeruleus-Norepinephrine Network
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xuanwu Hospital, Beijing
Anesthesia, Blood Pressure
Norepinephrine Prevent Post-induction Hypotension in High-risk Patients
The investigators aimed to investigate the effects of continuous infusion of norepinephrine before and after general anesthesia induction on the occurrence of post-induction hypotension.
- Conditions
- Anesthesia, Blood Pressure, Norepinephrine
- Trial name
- NCT06028256
- Testing
- Norepinephrine Hydrochloride
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Depression, Selective Serotonin Reuptake Inhibitor
Impact of Depression on Thermoregulation
The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with…
- Trial name
- NCT06805851
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hypotension, Fluid Therapy
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
A prospective, double-blinded study. The present study consisted in applying Stroke volume variation fluid guided therapy to old patients (65 years old) undergoing radical resection of colon surgery.
- Trial name
- NCT03215797
- Testing
- phenylephrine, Norepinephrine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Head and Neck Cancer
The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements
Vasopressors may be needed after head and neck microvascular reconstructions to maintain sufficient mean arterial pressure. This is crucial for the flap survival.
- Trial name
- NCT02241083
- Testing
- Dopamine, Norepinephrine, no medication
- Where
- Finland
- Volunteers
- 25 people
- Sponsor
- Tampere University Hospital
Vasoplegic Syndrome of Cardiac Surgery
Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery
This is a randomized, double-blind clinical trial designed to compare the inotropic effects of vasopressin versus norepinephrine in patients who develop vasoplegic syndrome in the immediate postoperative period following cardiac…
- Trial name
- INVASC (NCT06934798)
- Testing
- Vasopressin intravenous infusion, Norepinephrine intravenous infusion
- Where
- Brazil
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hypotension
Vasopressor Outcomes in Spine Surgery
This is a prospective, randomized control trial comparing norepinephrine versus phenylephrine for vasopressor support in patients undergoing elective spinal fusion surgery.
- Trial name
- V-SPINE (NCT06053398)
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Texas Southwestern Medical Center
Neurosurgery, Intervention
Pharmacokinetic and Pharmacodynamic Modelling of Norepinephrine in Patients Under Target Controlled Infusions (TCI) for Anaesthesia
Currently, administration of norepinephrine diluted at 5 µg/ml bolus or continuous infusion is common during sympatholysis hypotension of TCI following the elimination of hypovolemia or anesthetic overdosage.
- Trial name
- NOR-PHARM (NCT03454204)
- Testing
- Pharmacokinetic
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock
The purpose of this study is to assess the effect of norepinephrine and fluid expansion on capillary refill time during septic shock.
- Trial name
- NOVECAR (NCT04870892)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Bicetre Hospital
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Sepsis, Hypotension
Pre-induction Norepinephrine in Septic Patients Undergoing Surgery
This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.
- Trial name
- NCT07869693
- Testing
- Norepinephrine, Standard Care
- Volunteers
- 90 people
- Sponsor
- Assiut University
Vasopressor Agents, Endarterectomy, Carotid
Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery
This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia.
- Conditions
- Vasopressor Agents, Endarterectomy, Carotid, Echocardiography, Transesophageal
- Trial name
- NCT00294606
- Testing
- Comparison of Effects of Phenylephrine and Norepinephrine
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Brain Tumor
Effect of Preemptive Low Dose Norepinephrine Infusion on Intraoperative Hemodynamic Stability and Postoperative Outcomes in Patients Undergoing Brain Tumor Resection With a Craniotomy
In the experimental group, norepinephrine at a concentration of 5 mcg/ml is preemptively administered through peripheral venous catheter with a size of 20 G or more from the time of anesthesia induction to the end of anesthetic…
- Trial name
- NCT05814601
- Testing
- norepinephrine
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Healthy
Effectiveness of the Dual Serotonin Norepinephrine Reuptake Inhibitor Desvenlafaxine Succinate in Healthy Volunteers
DVS is the main metabolite of the antidepressant/anxiolytic medication Venlafaxine (Effexor). Like parent compound, DVS is an antidepressant inhibiting both serotonin (5-HT) and norepinephrine (NE) reuptake.
- Trial name
- DVS (NCT01101152)
- Testing
- Desvenlafaxine succinate
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Narcolepsy, Obstructive Sleep Apnea
SUNOSI® (Solriamfetol) Pregnancy Registry
The SUNOSI (solriamfetol) Pregnancy Registry is a US- and Canada-based prospective, observational study to evaluate the safety of solriamfetol exposure during pregnancy in women with a diagnosis of narcolepsy or obstructive sleep…
- Conditions
- Narcolepsy, Obstructive Sleep Apnea, Pregnant Women and Their Offspring
- Trial name
- NCT06413420
- Testing
- Sunosi (solriamfetol), Other prescription wake-promoting medications or stimulants, No treatment
- Where
- 2 sites in United States
- Volunteers
- 1,731 people
- Sponsor
- Axsome Therapeutics, Inc.
Role of the Noradrenergic System in the Regulation of Learning Dynamics, No Disease or Condition is Being Studied
Role of the Noradrenergic System in the Regulation of Learning Dynamics: Evaluation of the Effect of a Low-dose Selective Noradrenaline Reuptake Inhibitor (NOISYXETINE)
Administration of low-dose selective noradrenaline reuptake inhibitor (sNRI) (e.g. atomoxetine) to healthy subjects is a validated model of increasing cortical noradrenaline levels which, combined with computational modelling of…
- Trial name
- NOISYXETINE (NCT07239791)
- Testing
- Atomoxetine
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Anxiety Disorder
Duloxetine for Social Anxiety Disorder: Prediction of Long Term Outcome
The purpose of this study is to examine the safety and efficacy of duloxetine for the treatment of social anxiety disorder.
- Trial name
- NCT00114127
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Cesarean Section Complications, Hypotension
Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)
The goal of this clinical trial is to compare norepinephrine and ephedrine in maintaining blood pressure during spinal anaesthesia for elective cesarean delivery.
- Trial name
- INPEACE (NCT06248593)
- Testing
- Continuous infusion of Norepinephrine, Continuous infusion of Phenylephrine
- Where
- 2 sites in Morocco
- Volunteers
- 140 people
- Sponsor
- Hassan II University