Clinical trials: Normal, open to volunteers
Giant Cell Arteritis, Temporal Arteritis
Early Temporal Dynamics of Optic Nerve Sheath Diameter After Therapy in GCA
Giant cell arteritis (GCA) is an inflammatory disease of large and medium arteries that can cause irreversible vision loss. Glucocorticoids (GCs) rapidly suppress inflammation, but diagnostic imaging tests such as temporal artery…
- Conditions
- Giant Cell Arteritis, Temporal Arteritis, Optic Nerve Diseases, Diagnosis
- Trial name
- SONIC-TIME (NCT07508514)
- Testing
- Optic Nerve Sheath Ultrasound, Temporal artery ultrasound, Bloodwork : CRP and ESR
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Panniculitis, Dermatomyositis
Panniculitis in Dermatomyositis
Adipose tissue involvement is rare in dermatomyositis. The occurrence of partial or diffuse lipodystrophy is a rare but well-characterized manifestation, particularly in juvenile forms of dermatomyositis.
- Trial name
- PANNICUL (NCT07345949)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Breast Cancer, Chemotherapy-induced Nausea and Vomiting
Efficacy and Safety of Intravenous Versus Oral 5-HT3 Antagonists Combined With NK-1 Receptor Antagonists for the Prevention of CINV in Breast Cancer
Chemotherapy is one of the most common treatments for breast cancer, but the adverse effects can be severe enough to delay or make chemotherapy intolerable, thus affecting the efficacy of the disease.
- Trial name
- NCT05841849
- Testing
- Aprepitant, Palonosetron, Fosaprepitant
- Where
- China
- Volunteers
- 1,028 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Advanced Malignancies, Ovarian Cancer
BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
The goal of this first in human clinical trial is to test BI-1808 administered as single agent and in combination with pembrolizumab in subjects with advanced malignancies whose disease has progressed after standard therapy.
- Conditions
- Advanced Malignancies, Ovarian Cancer, T-cell Lymphoma, Melanoma
- Trial name
- NCT04752826
- Testing
- BI-1808, Pembrolizumab (KEYTRUDA® ) 25 Mg/mL Solution for Injection, Paclitaxel 80 mg/m2 weekly
- Where
- 25 sites in United States, Denmark and 5 more
- Volunteers
- 250 people
- Sponsor
- BioInvent International AB
Neuroblastoma
Clinical Analysis of Naxitamab (hu3F8) in the Treatment of Pediatric High Risk or Refractory/ Relapsed Neuroblastoma
This is an prospective study to evaluate the safety and efficacy of naxitamab monotherapy or combined with chemotherapy or combined with chemotherapy and checkpoint inhibitor in the treatment of pediatric high-risk and…
- Trial name
- NCT06013618
- Testing
- Naxitamab monotherapy, GM-CSF, Irinotecan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-Sen University Cancer Center
Antineutrophil Cytoplasmic Antibody-associated Vasculitis
A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
The primary objective of this study is to evaluate the long-term safety of avacopan in participants with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
- Trial name
- AVASET (NCT06072482)
- Testing
- Avacopan, Standard of Care
- Where
- 83 sites in United States, Czechia and 5 more
- Volunteers
- 300 people
- Sponsor
- Amgen
Rheumatoid Arthritis (RA
Pix-Risk: Early Detection of Rheumatoid Arthritis Via the DETECTRA Platform
The goal of this clinical trial is to learn if a remote monitoring application called DETECTRA can help doctors diagnose rheumatoid arthritis earlier in people who are at risk of developing the disease.
- Trial name
- Pix-Risk (NCT07825233)
- Testing
- DETECTRA, Standard of Care (SOC)
- Where
- 5 sites in Austria, Denmark and 2 more
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Glioblastoma, Cerebral Metastases
Impact of Salovum® and SPC® Flakes on Brain Tumor Induced Edema
The objective of this clinical trial is to explore the effects of Salovum®, an egg yolk powder enriched with the endogenous protein antisecretory factor, and SPC® flakes , hydrothermically processed oats, on cerebral edema with…
- Conditions
- Glioblastoma, Cerebral Metastases, Meningioma
- Trial name
- AFBTEdema (NCT06710249)
- Testing
- Salovum/SPC flakes
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Peter Siesjö
Melanoma (Skin Cancer)
MELanoma Brain Metastasis Treated With CYberknife
Melanoma is a type of cancer that can spread to the brain, making the disease harder to treat and worsening both survival and quality of life.
- Trial name
- MELCY (NCT07691255)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- European Institute of Oncology
Hyperhidrosis
20% Alcohol With Steroid Local Anesthetic Technique Versus Steroid Local Anesthetic Technique Only in Stellate Ganglion Injection in Idiopathic Palmar Hyperhydrosis
Palmar hyperhidrosis is a medical condition characterized by excessive sweating specifically from the palms of the hands. This condition can significantly impact an individual's quality of life, leading to social embarrassment…
- Trial name
- NCT07788326
- Testing
- Group A, Group B
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Parkinson's Disease
A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery
The investigators propose a Phase I single surgical-center, double-blinded randomized parallel clinical trial involving bilateral autologous peripheral nerve tissue (PNT) delivery into the NBM or the alternate target also…
- Trial name
- STAR (NCT06683378)
- Testing
- Reparative Autologous peripheral nerve tissue
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Craig van Horne, MD, PhD
Cancer, Breast Cancer
REstoring Metabolic FLEXibility Through Combined Exercise in Breast Cancer Survivors: A Randomized Controlled Trial.
The REFLEX study is a randomized, controlled clinical trial designed to evaluate the impact of a 16-week supervised, combined exercise program on metabolic flexibility and cardiorespiratory fitness in breast cancer survivors.
- Conditions
- Cancer, Breast Cancer, Neoplasm, Metabolic Flexibility
- Trial name
- REFLEX (NCT07405385)
- Testing
- Control, Exercise
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Castilla-La Mancha
Breast Neoplasms, Breast Cancer
Surgical Outcome of BCS Using ICG-F in Breast Cancer Patients After Preoperative Chemotherapy
Neoadjuvant chemotherapy for advanced breast cancer has led to an increased rate of breast-conserving surgery (BCS) in these patients.
- Trial name
- NCT06780735
- Testing
- The margin-positive rate using the localization technique
- Where
- South Korea
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Normal Pressure Hydrocephalus
Identifying Gait Changes From a CSF Tap Test Using a Smart Insole in iNPH
The goal of this clinical trial is to to evaluate various gait parameters by a sensor-embedded smart insole before and after the cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH) patients.
- Trial name
- NCT06722768
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Soft-tissue Sarcoma, Triple Negative Breast Cancer
Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies
This is a Phase 1b/IIa dose escalation clinical trial determining the recommended phase II dose of SPEDOX-6 in subjects with advanced, therapy-refractory soft-tissue sarcoma (STS); triple-negative breast cancer (TNBC); Non-small…
- Conditions
- Soft-tissue Sarcoma, Triple Negative Breast Cancer, Non-small Cell Lung Cancer, Cervical Cancer
- Trial name
- NCT07064018
- Testing
- Spedox-6, Pegfilgrastim, Filgrastim
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of California, Irvine
Medullary Thyroid Carcinoma
Research on the Application of 68Ga-DOTA-CCK-FS PET/CT in MTC
This study explores the clinical application of 68Ga-DOTA-CCK-FS PET/CT in detecting cholecystokinin-2 receptor (CCK-2R)-positive tumors, particularly medullary thyroid cancer (MTC) and other malignancies. Led by Prof.
- Trial name
- NCT07138716
- Testing
- 68Ga-DOTA-CCK-FS PET/CT
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Luo Yaping
Takayasu Arteritis (TAK)
The Efficacy and Safety of Deucravacitinib in Takayasu's Arteritis
This is a 24-week, single-center, randomized, open-label trial conducted by Peking Union Medical College Hospital. The aim of this study is to assess the efficacy and safety of deucravacitinib in adult patients with relapsing TAK…
- Trial name
- NCT07013838
- Testing
- Deucravacitinib, Adalimumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese SLE Treatment And Research Group
Obesity
Body Composition Outcomes in MS Patients
Objectives The objective of this project is to generate pilot data substantiating our hypothesis that advanced body composition measurement tools will provide more accurate and clinically relevant data on the outcomes of…
- Trial name
- BCOMS (NCT07530718)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pennington Biomedical Research Center
IBD (Inflammatory Bowel Disease), IBD
Ex-vivo Confocal Imaging and Proteomic Profiling to Determine Treatment Response in Children With IBD
This study aims to test the overall hypothesis that the membrane tissue binding capacity of cytokines in the biopsied tissue of patients with Inflammatory Bowel Disease (IBD) is predictive of/strongly correlated to clinical…
- Conditions
- IBD (Inflammatory Bowel Disease), IBD, IBD - Inflammatory Bowel Disease
- Trial name
- NCT07121920
- Testing
- Confocal Laser Endomicroscopy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Cook Children's Health Care System
Breast Cancer
Single-fraction APBI for Early-stage Breast Cancer With Favorable Histological Subtypes (Breast-1F)
This is a prospective, randomized, monocentric, non-inferiority interventional clinical study comparing an Accelerated Partial Breast Irradiation (APBI) for the surgical bed of early-stage breast cancer patients with favorable…
- Trial name
- Breast-1F (NCT06946238)
- Testing
- Adjuvant single-fraction accelerated partial breast irradiation
- Where
- Italy
- Volunteers
- 311 people
- Sponsor
- IRCCS San Raffaele
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