Clinical trials: Normal Skin
Breast Cancer
Take-Care Program: Effectiveness of a Physical Therapy Program on Cancer Related Symptoms
Effectiveness of a physical therapy program focussed on core stability exercise and massage as a recovery method in breast cancer survivors after oncology treatment.
- Trial name
- TAKE-CARE (NCT01274806)
- Testing
- Physical Therapy
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Instituto de Salud Carlos III
Metastatic Breast Cancer
Effects of Granulocyte Colony-stimulating Factor (G-CSF), Trastuzumab, and Vinorelbine on Immune Cell Function
Trastuzumab or Herceptin is an antibody directed against Her-2. Her-2 is a growth factor receptor which is present on the tumors of 25% of patients with breast cancer.
- Trial name
- NCT00169104
- Testing
- G-CSF, trastuzumab, vinorelbine
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Ticagrelor, Aspirin
Reversal of the Antiplatelet Effects of Ticagrelor in Combination With Aspirin, Using Normal Platelets
The specific objective of this study is to investigate the potential for normal platelets to reverse the inhibition of platelet aggregation in patients treated with ticagrelor in combination with aspirin.
- Conditions
- Ticagrelor, Aspirin, Platelet Dysfunction Due to Drugs, Transfusion
- Trial name
- REVSTARTS (NCT03005704)
- Testing
- Antiplatelet treatment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Rheumatoid Arthritis, Inflammation
Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid Arthritis
Recent studies show beneficial effect of the inhibition of interleukin-6 (IL-6) activity on vascular and left ventricular (LV) function.
- Trial name
- NCT03288584
- Testing
- Tocilizumab (Actemra®), Other biological agent, Corticosteroid and non-biological agents.
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Dysphonia
Computational Cranial and Cervical Muscle Network in Normal and Disordered Voice
The long-term goal is to transform the diagnosis and treatment of dysphonia by elucidating cervical and cranial neuromuscular mechanisms underlying typical and disordered voicing.
- Trial name
- NCT04713033
- Testing
- surface electromyogram (sEMG), flexible laryngoscopy
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Breast Cancer
The Potential for Oral Diindolylmethane (DIM) Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers
Women with a BRCA1 mutation face a lifetime risk of breast cancer of approximately 70% and a lifetime risk of ovarian cancer of approximately 40%.
- Trial name
- NCT01022333
- Testing
- Diindolylmethane (DIM)
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Breast Neoplasms, Breast Cancer Detection
Diagnostic Accuracy of Carebot AI MMG in Mammography Screening: Multicenter MRMC Study
This study evaluates the diagnostic performance of Carebot AI MMG, an artificial intelligence (AI)-enabled medical device for evaluating mammograms.
- Conditions
- Breast Neoplasms, Breast Cancer Detection, Breast Cancer - Female, Breast Cancer Screening
- Trial name
- CARE-MMG-MRMC (NCT07298252)
- Testing
- Carebot AI MMG software analysis
- Where
- 4 sites in Czechia, Slovakia
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Carebot s.r.o.
Tinea Cruris, Jock Itch
Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Cruris
A research study to compare the safety and effectiveness of an investigational medication called NAFT-500 to placebo (no active treatment), when used in subjects with tinea cruris, also known as jock itch.
- Trial name
- NCT00750152
- Testing
- NAFT-500
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Breast Cancer
Do Skin Markings Reflect the Location of the Surgical Cavity During Daily Radiotherapy Treatment?
Markings placed on the skin are an accurate representation of the underlying surgical cavity and are adequate to use for patient setup for accelerated partial breast irradiation.
- Trial name
- NCT00578747
- Where
- 2 sites in Canada
- Volunteers
- 21 people
- Sponsor
- British Columbia Cancer Agency
Brain and Central Nervous System Tumors, Childhood Langerhans Cell Histiocytosis
Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other sources to damage tumor cells. Giving radiation therapy in different ways may kill more tumor cells.
- Conditions
- Brain and Central Nervous System Tumors, Childhood Langerhans Cell Histiocytosis, Gastrointestinal Carcinoid Tumor, Head and Neck Cancer
- Trial name
- NCT00002947
- Testing
- indium In 111 pentetreotide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Yale University
Breast Cancer
Breast Screening Atypia and Subsequent Development of Cancer in England
During breast screening, atypical epithelial proliferations (atypia) can be detected. These are not cancer, but may mean that a woman is more likely to develop breast cancer in the future.
- Trial name
- NCT05402436
- Testing
- A diagnosis of atypia as part of the English screening programme
- Where
- United Kingdom
- Volunteers
- 3,238 people
- Sponsor
- University of Warwick
Psoriasis Vulgaris
LEO 32731 for the Treatment of Moderate to Severe Psoriasis Vulgaris
A study of LEO 32731 in the treatment of psoriasis vulgaris
- Trial name
- NCT02888236
- Testing
- LEO 32731
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- LEO Pharma
Atopic Dermatitis
Dose-ranging Study of Nemolizumab in Atopic Dermatitis
Assess the efficacy of several subcutaneous doses of nemolizumab in moderate-to-severe atopic dermatitis (AD) subjects with severe pruritus receiving TCS, who were not adequately controlled with topical treatments.
- Trial name
- NCT03100344
- Testing
- Nemolizumab
- Where
- 67 sites in United States, Australia and 4 more
- Volunteers
- 226 people
- Sponsor
- Galderma R&D
Breast Cancer
Study of Neoadjuvant Chemotherapy of Breast Cancer
The purpose of this study is to evaluate the pathological CR rate in breast and lymph nodes of a novel neoadjuvant regimen for invasive breast carcinoma.
- Trial name
- Neoadjuvant (NCT00830544)
- Testing
- Neoadjuvant chemotherapy, Chemotherapy
- Where
- Puerto Rico
- Volunteers
- 54 people
- Sponsor
- Auxilio Mutuo Cancer Center
Solid Tumors, Breast Cancer
Clinical Trial of the Combination of Trastuzumab (Herceptin) and Tanespimycin in Patients With Solid Tumors and Her2 Positive Metastatic Breast Cancer That Have Previously Failed Herceptin
The primary purpose(s) of this study is to determine the highest tolerated dose of tanespimycin and to determine anti-tumor activity (via objective response rate) of tanespimycin in patients with breast cancer who have not…
- Trial name
- NCT00773344
- Testing
- Tanespimycin
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Bristol-Myers Squibb
Wounds and Injuries, Cancer Pain
Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds
The goal of this clinical trial is to compare in compare pain reduction in patients with malignant wounds using morphine gel or lidocaine gel.
- Conditions
- Wounds and Injuries, Cancer Pain, Cancer, Breast, Cancer Head Neck
- Trial name
- MorphineGEL (NCT05800834)
- Testing
- Morphine Sulfate, Lidocaine Hcl 2% Jelly
- Where
- Brazil
- Volunteers
- 106 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Palmar-plantar Erythrodysesthesia (PPE)
Testing the Effectiveness of Henna on Managing PPE
The palmar-plantar erythrodysesthesia (PPE) is the only clinical adverse event that commonly occurs with capecitabine and/or pegylated liposomal doxorubicin treatment and it warrants special attention because it is the most…
- Trial name
- NCT01751893
- Testing
- Henna
- Where
- Cyprus
- Volunteers
- 56 people
- Sponsor
- Cyprus University of Technology
Breast Cancer, Mastectomy
Post-Operative Outcomes of Low Thermal Dissection vs. Traditional Electrosurgery
Low thermal dissection devices have been introduced as a tool to improve surgical outcomes. PlasmaBlade, a low thermal dissection device, has shown to be associated with effective cutting, and significantly lower temperature than…
- Conditions
- Breast Cancer, Mastectomy, Perfusion; Complications, Hemostasis
- Trial name
- NCT03711916
- Testing
- PlasmaBlade 3.0S
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hepatic Impairment (HI)
A Study to Evaluate EDG-7500 in Adults With Hepatic Impairment
The purpose of this Phase 1 study is to understand and compare the amount of EDG-7500 in the blood after a single dose in participants with different levels of liver function impairment versus participants with normal liver…
- Trial name
- NCT07324616
- Testing
- EDG-7500
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Edgewise Therapeutics, Inc.
Metastatic Breast Cancer
Therapy Management With Nab-Paclitaxel in Daily Routine
Despite treatment improvements in breast cancer, a large number of patients still progress to the metastatic stage. Metastatic breast cancer patients have an extremely unfavorable prognosis.
- Trial name
- SERAPHINA (NCT02642406)
- Where
- 83 sites in Germany
- Volunteers
- 1,200 people
- Sponsor
- University Hospital Tuebingen
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