Clinical trials: Normal Skin
Leg Ulcers
Physiotulle vs Urgotul in the Treatment of Leg Ulcer
The aim of this study is to assess the pain at removal of Physiotulle dressing in comparison with that of Urgotul dressing in patients presenting a venous (or predominantly) venous leg ulcer.
- Trial name
- NCT01238419
- Testing
- Physiotulle, URGOTUL
- Where
- 34 sites in Denmark, France
- Volunteers
- 188 people
- Sponsor
- Coloplast A/S
Breast Cancer
MRI-Guided Ultrasound Stimulated Microbubbles Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer
The objective of this study is to demonstrate the feasibility of novel Magnetic Resonance Imaging (MRI)-guided ultrasound stimulated microbubble treatment to enhance radiation effects in humans receiving external beam…
- Trial name
- NCT06633601
- Testing
- MR-Guided Focused Ultrasound Technology, Definity Suspension for Injection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Melanoma
Nivolumab Plus Radiotherapy in Advanced Melanoma
Combining nivolumab with conventional multisite high dose radiotherapy seems to be an interesting approach that could increase the antitumoral effect of nivolumab by increasing the diversity and quantity of tumoral antigen…
- Trial name
- NIRVANA (NCT02799901)
- Testing
- Nivolumab, hypofractionned radiotherapy
- Where
- 14 sites in France
- Volunteers
- 72 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Breast Neoplasms, Pain, Postoperative
Serratus Anterior Plane Block to Prevent Chronic Postoperative Pain in Breast Cancer
Chronic postoperative pain (CPP) remains a disturbing and obscure clinical problem. The hypothesis of this trial is that a peripheral block of the serratus anterior plane block type preoperatively after a modified radical…
- Conditions
- Breast Neoplasms, Pain, Postoperative, Pain, Chronic, Post-Mastectomy Chronic Pain Syndrome
- Trial name
- USB22 (NCT05494281)
- Testing
- Serratus Anterior Plane Block with local anesthetic, Serratus Anterior Plane Block with saline solution
- Where
- Morocco
- Volunteers
- 94 people
- Sponsor
- Moroccan Society of Surgery
Metastatic Breast Cancer, Breast Cancer Stage IV
BRaziLian outcomE for metAStatic breasT Cancer
Given the certain benefit in efficacy of adding CDK 4/6 inhibitor to first line endocrine therapy in metastatic breast cancer HR+ HER2- , the aim of this project is to evaluate whether patients without private health insurance…
- Trial name
- BREAST (NCT05559528)
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Hospital do Coracao
Lupus Erythematosus, Systemic, Lupus Nephritis
A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)
The purpose of this study is to evaluate the efficacy, safety and drug levels of CC-97540 in participants with active systemic lupus erythematosus (SLE) including lupus nephritis with inadequate response to glucocorticoids and at…
- Trial name
- NCT07015983
- Testing
- CC-97540, Fludarabine, Cyclophosphamide
- Where
- 97 sites in United States, Argentina and 14 more
- Volunteers
- 89 people
- Sponsor
- Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Foramen Ovale, Patent, Nickel Sensitivity
Investigation of Nickel Sensitization After Percutaneous Implantation of Patent Foramen Ovale Occluder
Percutaneous PFO closure has been established as a first-line therapy for preventing recurrent strokes in selected patients. The devices used for the specific purpose contain and release nickel, which is considered as the most…
- Conditions
- Foramen Ovale, Patent, Nickel Sensitivity, Dermatitis Contact Irritant, Metal Allergy
- Trial name
- INSPIRE (NCT04713683)
- Testing
- Percutaneous Patent Foramen Ovale Closure
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- National and Kapodistrian University of Athens
Psoriasis Vulgaris
Comparison of Refined and Crude Indigo Naturalis Ointment in Treating Psoriasis
To compare the efficacy and safety of refined indigo naturalis ointment with that of crude ointment in treating psoriasis.
- Trial name
- NCT01022502
- Testing
- refined indigo naturalis ointment, crude indigo naturalis ointment
- Where
- Taiwan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Yin-ku Lin
Hormone Receptor-positive Breast Cancer, HER2-negative Breast Cancer
ONO-4578-06:Phase I Study of ONO-4578 and Letrozole Plus CDK4 /6 Inhibitors in Breast Cancer
This is a multicenter, open-label, non-controlled, phase I study to investigate the tolerability and safety of ONO-4578 used in combination with standard-of-care letrozole and a CDK4/6 inhibitor (palbociclib or Abemaciclib) as…
- Conditions
- Hormone Receptor-positive Breast Cancer, HER2-negative Breast Cancer, Metastatic Breast Cancer, Recurrent Breast Cancer
- Trial name
- NCT06570031
- Testing
- ONO-4578, letrozole, Palbociclib
- Where
- 13 sites in Japan
- Volunteers
- 46 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block
Comparison of Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block
Breast cancer is the most common malignancy in women. Modified radical mastectomy, a surgical procedure in the treatment of breast cancer, is one of the standard treatments.
- Conditions
- Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block, Acute Pain, Postoperative Pain
- Trial name
- NCT06407037
- Testing
- Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Lichen Sclerosus of Vulva
Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT03045172
- Testing
- Platelet Rich Plasma
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Center for Vulvovaginal Disorders
Metastatic Breast Cancer
ER Reactivation Therapy for Breast Cancer
Before anti-estrogens such as tamoxifen were developed to treat estrogen receptor (ER)-positive breast cancer, high-dose estrogen therapies were used.
- Trial name
- POLLY (NCT02188745)
- Testing
- 17B-estradiol, Letrozole, Anastrozole
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Neoplasms
A Study of E7090 as Monotherapy and in Combination With Other Anticancer Agents in Participants With Estrogen Receptor Positive (ER+) and Human Epidermal Growth Receptor 2 Negative (HER2-) Recurrent/Metastatic Breast Cancer
The primary purpose of this study is to evaluate the tolerability and safety of E7090 as monotherapy and in combination with other anticancer agents in participants with ER+, HER2- recurrent/metastatic breast cancer and to…
- Trial name
- NCT04572295
- Testing
- E7090, Fulvestrant, Exemestane
- Where
- 11 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Eisai Co., Ltd.
Melanoma
Suicide Plus Immune Gene Therapy for Advanced Melanoma
Safety evaluation of combined immunogene therapy in patients with advanced melanoma.
- Trial name
- IGTM-101 (NCT03338777)
- Testing
- Suicide plus immunogene therapy
- Where
- Argentina
- Volunteers
- 4 people
- Sponsor
- Hospital Italiano de Buenos Aires
Chondromalacia Patellae
Is Lower Limb Neuromotor Control Diverse in Females With PF OA Contrasted With Asymptomatic Controls
Objective: to investigate whether females with PF OA descend stairs with different muscular recruitment strategies contrasted with similar aged healthy females.
- Trial name
- NCT05407077
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Recessive Dystrophic Epidermolysis Bullosa
Allogeneic ABCB5-positive Stem Cells for Treatment of Epidermolysis Bullosa
The aim of this clinical trial is to investigate the efficacy (by monitoring overall improvement of EB symptoms) and safety (by monitoring adverse events) of three doses of allo-APZ2-EB administered intravenously to patients with…
- Trial name
- NCT03529877
- Testing
- allo-APZ2-EB
- Where
- 6 sites in United States, Austria and 3 more
- Volunteers
- 16 people
- Sponsor
- RHEACELL GmbH & Co. KG
Melasma
Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study
1. To evaluate the efficacy and safety of topical resveratrol 1 % gel in treatment of melasma. 2. To compare between the efficacy of topical resveratrol 1 %gel versrs chemical peeling with TCA 20% in melasma.
- Trial name
- NCT07060157
- Testing
- resveratrol 1 % gel, TCA20%
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Assiut University
Renal Impairment
Phase 1 Study of PK and Safety of HM15912 (Sonefpeglutide) in Subjects With Normal and Severe Kidney Function
An Open-label, Single-dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability of HM15912 in Subjects with Renal Impairment and Matched Control Subjects with Normal Renal Function
- Trial name
- NCT05711381
- Testing
- HM15912
- Where
- 4 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Vitiligo, Melanoma (Skin)
Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo
This study examines melanoma and nonmelanoma skin cancer in people diagnosed with vitiligo compared to matched controls.
- Conditions
- Vitiligo, Melanoma (Skin), Nonmelanoma Skin Cancer, Squamous Cell Carcinoma
- Trial name
- NCT04969419
- Testing
- Exposure of skin cancer of interest
- Where
- United Kingdom
- Volunteers
- 75,771 people
- Sponsor
- Momentum Data
Breast Cancer
Red Bull Energy Drink Intake After Autologous Microsurgical Breast Reconstruction
The success rate of autologous microsurgical breast reconstruction depends on adequate intraoperative and postoperative flap perfusion.
- Trial name
- NCT04397419
- Testing
- Red Bull Energy Drink, Still water
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Plastic Surgery Group AG by Prof. Jian Farhadi
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