Clinical trials: Normal Skin
Melasma
Development of Products Based on Secretom From Stem Cell Conditioned Medium for Melasma Therapy
This research is a clinical study with a single-blind randomized clinical trial design (randomized controlled trial) in RSCM-FKUI This study aims to Assess the effectiveness and safety of intradermal concentrated secretome…
- Trial name
- NCT06516419
- Testing
- Concentrated secretome Injection 2mL, Tranexamic acid injection, Triple Combination Cream
- Where
- 2 sites in Indonesia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Breast Neoplasms
A Non-interventional Study for Kisqali (Ribociclib) in Combination With an Aromatase Inhibitor for Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer at High Risk of Recurrence
This non-interventional observational study evaluates the real-world effectiveness and safety profile of ribociclib in combination with an aromatase inhibitor for adjuvant treatment in patients with HR+/HER2- early breast cancer…
- Trial name
- CAROLEEN (NCT06830720)
- Testing
- ribociclib + AI ± LHRH, abemaciclib + ET ± LHRH, ET mono ± LHRH
- Where
- 287 sites in Austria, Germany
- Volunteers
- 3,250 people
- Sponsor
- Novartis Pharmaceuticals
Dyspepsia
Gastric Motor Function Measurement in Dyspepsia and Normal Subjects
This study is being done to measure the functions of the stomach after eating a meal and to develop a new method that will simultaneously measure both gastric emptying and the relaxation of the stomach after a meal using nuclear…
- Trial name
- NCT00296582
- Testing
- Gastric Motor Function Measurement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Arthritis, Rheumatoid
Long-term Efficacy and Safety of Repeated Ofatumumab Treatment Courses in RA Patients Who Previously Received Ofatumumab or Placebo in Trial Hx-CD20-403
A 3-year open-label trial for patients who previously participated in Trial Hx-CD20-403 and who fulfill the eligibility criteria for this trial (GEN413) .
- Trial name
- NCT00655824
- Testing
- ofatumumab
- Where
- 10 sites in United States, Denmark and 3 more
- Volunteers
- 124 people
- Sponsor
- GlaxoSmithKline
Diabetic Foot Ulcer
High Tone External Muscle Stimulation on Diabetic Foot Ulcer
In this study 80 patients will be randomly assigned into two equal groups (40 patients for each group): 1. Group A: Experimental: (high tone external muscle stimulation for diabetic foot ulcer).
- Trial name
- NCT06664723
- Testing
- high tone external muscle stimulation, Standard medical treatment (SMT)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Diabetes Mellitus, Normal Glucose Metabolism
Assessment of Non-Fasting vs. Fasting Lipid Measures in Diabetes Patients
This study will examine whether fasting and non-fasting lipid measures can provide similar clinical information in order to guide lipid management by primary physicians. It will compare fasting vs.
- Conditions
- Diabetes Mellitus, Normal Glucose Metabolism, Hyperlipidemia
- Trial name
- NCT00569959
- Testing
- fasting 12+ hours, Non-fasting
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Cutaneous Melanoma, Merkel Cell Carcinoma
EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers
This phase II trial tests how well EMLA topical cream works in treating pain in patients with skin cancers receiving Technetium 99 injections for a lymphoscintigraphy mapping procedure.
- Conditions
- Cutaneous Melanoma, Merkel Cell Carcinoma, Skin Squamous Cell Carcinoma
- Trial name
- NCT06223659
- Testing
- Eutectic Mixture of Local Anesthetics, Questionnaire Administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Pseudoxanthoma Elasticum
Phenotypic Expressions in a French Pseudoxanthoma-Elasticum Cohort
The cohort is intended to study the phenotypic expressions of the pseudoxanthoma elasticum (PXE) disease in various tissues (eye, skin, arteries, etc).
- Trial name
- NCT01446380
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Angers
Cutaneous Leishmaniasis
Safety and Efficacy of Low-Dose Pentavalent Antimony for Treatment of Cutaneous Leishmaniasis
The purpose of this study is to determine whether low-dose pentavalent antimony is equally effective when compared to the standard-dose regimen in patients with cutaneous leishmaniasis.
- Trial name
- Lowdosesb (NCT00317980)
- Testing
- Meglumine antimoniate
- Where
- Brazil
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Androgenic Alopecia
Umbilical Cord-derived Mesenchymal Stem Cell Exosomes on Hair Growth in Patients With Androgenetic Alopecia
A total of 50 patients with androgenetic alopecia were selected for the study. Patients who met the inclusion/exclusion criteria were randomly assigned to groups A and B in a 1:1 ratio to receive treatment, with the enrollment…
- Trial name
- NCT06697080
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Venous Thromboses, Venous Thromboembolism
The Risk of Venous Thromboembolism in Systemic Inflammatory Disorders: a United Kingdom (UK) Matched Cohort Study
Blood clots occurring in the legs and in the lungs are relatively common; they occur in around 3 in a 1000 people per year. They can cause disability and are also potentially life threatening.
- Conditions
- Venous Thromboses, Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT03835780
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 266,890 people, healthy volunteers welcome
- Sponsor
- Momentum Data
TNBC - Triple-Negative Breast Cancer
The Efficacy and Safety of Utidelone Plus Tirelizumab and Bevacizumab for Advanced or Metastatic Triple-negative Breast Cancer (UTILIZABLE) ：Single-arm, Prospective, Open Clinical Study
This is a multicenter, open-label, single-arm clinical study designed to evaluate the safety and efficacy of Utidelone plus Tirelizumab and Bevacizumab for advanced or metastatic triple-negative breast cancer (TNBC).
- Trial name
- UTILIZABLE (NCT06125080)
- Testing
- Utidelone, Tirelizumab, Bevacizumab
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Huihua Xiong
Incontinence-associated Dermatitis
Prevention of Incontinence-associated Dermatitis
Incontinence-associated dermatitis (IAD) is an inflammation of the skin caused by prolonged direct contact of the skin with urine and/or stool. Elderly and care-dependent people are often affected by this type of inflammation.
- Trial name
- PID (NCT05403762)
- Testing
- ESENTA™ Skin Barrier Spray (ConvaTec, UK), Hydrophobes Basisgel DAC
- Where
- Germany
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer
Serum Retinoic Acid Induced Protein 14 (RAI14) and Metastasis Associated Cancer Colon -1 (MACC-1) in Breast Cancer
1. Measurement of serum levels of Retinoic acid induced 14 (RAI14) and Metastasis associated cancer colon -1 (MACC-1) as biomarkers for diagnosis of breast cancer. 2.
- Trial name
- NCT06097546
- Testing
- laboratory test (RAI14 and MACC-1 )
- Volunteers
- 90 people
- Sponsor
- Assiut University
Breast Cancer
Neoadjuvant DPX-Survivac Aromatase Inhibition, Radiotherapy or Cyclophosphamide in HR+HER2- Breast Cancer
The study seeks to establish the safety of neoadjuvant aromatase inhibitor with: DPX-Survivac, DPX-Survivac plus radiation, or DPX-Survivac with cyclophosphamide in stage I to III HR+HER2- breast cancer.
- Trial name
- NCT04895761
- Testing
- DPX-Survivac, Letrozole 2.5mg, Cyclophosphamide 50mg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Providence Health & Services
COVID-19
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects With Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function
This is a Phase 1 non-randomized, open-label, multiple dose, parallel-group study of ALG-097558 in subjects with moderate hepatic impairment and subjects without hepatic impairment, matched for age, body weight and, to the extent…
- Trial name
- NCT06568861
- Testing
- ALG-097558
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
Breast Cancer, TNBC
Comparing UTD2 Combined With Capecitabine to Capecitabine as Adjuvant Therapy for Non-pCR TNBC Patients
Evaluate the IDFS rate, overall survival (OS) rate, and safety profile of UTD2 combined with capecitabine versus capecitabine monotherapy as adjuvant therapy for triple-negative early breast cancer patients who did not achieve…
- Trial name
- NCT07021261
- Testing
- Utidelone plus capecitabine, Capecitabine
- Volunteers
- 440 people
- Sponsor
- Fudan University
Triple Negative Breast Cancer
Efficacy of Interleukin-2 in Triple Negative Breast Cancer
This study is a single arm, phase II pilot design. The study will evaluate the safety and efficacy of intralesional immunotherapy (e.g. IL-2) in early stage TNBC.
- Trial name
- NCT05821686
- Testing
- Human Interleukin-2 (IL-2) (Proleukin)
- Volunteers
- 10 people
- Sponsor
- Nova Scotia Health Authority
Metastatic Breast Cancer
Capecitabine, Oxaliplatin and Trastuzumab in Treating Patients With HER2 Positive Metastatic Breast Cancer
In vitro data suggest synergy between oxaliplatin and 5-FU. The combination of oxaliplatin with 5-fluorouracil produced objective response rates ranging from 27-34% in two studies of patients with prior chemotherapy.
- Trial name
- NCT00216073
- Testing
- Capecitabine, Oxaliplatin, Trastuzumab
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Hoosier Cancer Research Network
Pain, Itch
Topographical Distribution of Itch and Pain Receptors
The experiment consists of three experimental sessions conducted on three consecutive days. In all experimental sessions, the participant will fill in a series of questionnaires about how you perceive itch and pain, and about…
- Trial name
- NCT07122973
- Testing
- Histamine, Cowhage, Capsaicin 8% Patch
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
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