Clinical trials: Normal Tension Glaucoma
Glaucoma Open-Angle
Normal Tension and Chronic Open Angle Glaucoma and Cerebrospinal Fluid Composition
Normal tension glaucoma (NTG) and chronic open angle glaucoma (COAG) occurring progressively with optimal conventional or intraocular pressure reducing surgery are still unsolved problems in ophthalmology.
- Trial name
- NCT00306657
- Testing
- Optic nerve sheath fenestration
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Kantonsspital Aarau
Primary Open Angle Glaucoma, Ocular Hypertension
Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging
Glaucoma is among the leading causes for blindness in the western world. Elevated intraocular pressure (IOP) has been identified as the most important risk factor.
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension, Normal Tension Glaucoma
- Trial name
- NCT01864317
- Testing
- 7-Tesla MRI, Optical Coherence Tomography, Heidelberg Retina Tomography
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Normal Tension Glaucoma, Cataract
Endoscopic Cyclophotocoagulation in Normal Tension Glaucoma
The purpose of this study is to assess whether endoscopic cyclophotocoagulation added to cataract surgery lowers intraocular pressure more than cataract surgery alone in patients with normal tension glaucoma.
- Trial name
- ECPNTG (NCT04651530)
- Testing
- Phaco, Phaco+ECP
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Normal Tension Glaucoma (NTG)
A Study to Evaluate Safety and Tolerability of QLS-101 in NTG
A randomized active-controlled multi-site double-masked 28 day study to evaluate the safety and tolerability of QLS-101 versus timolol maleate Preservative Free (PF) 0.5% ophthalmic solution in subjects with normal tension…
- Trial name
- NCT04857827
- Testing
- QLS-101, Timolol maleate PF 0.5% ophthalmic solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Qlaris Bio, Inc.
Open Angle Glaucoma, Normal Tension Glaucoma
Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study
Glaucoma is a leading cause of blindness worldwide, whose treatment - intraocular pressure lowering - is only partially effective in preventing disease progression.
- Trial name
- NCT01840202
- Where
- Belgium
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Renal Insufficiency, Chronic, Glaucoma
Intraocular Pressure and Hemodialysis Midwestern Brazil
Objective: To evaluate the variation in intraocular pressure in patients with chronic kidney disease, according to the time interval between hemodialysis sessions and to the influence of weight and blood pressure on intraocular…
- Trial name
- EHPIOBRAZIL (NCT02405884)
- Testing
- Kowa HA-2 Perkins applanation tonometer.
- Volunteers
- 39 people
- Sponsor
- VER Excelência em Oftalmologia
Normal Tension Glaucoma, High Tension Glaucoma
Differences in Nerve Fiber Layer Between Patients With Normal- and High-Pressure-Glaucoma
The purpose of the study is to prove if there is any difference in the nerve fiber layer between patients with normal- and high-tension-glaucoma with similar structural optic nerve head parameters.
- Trial name
- NCT01488032
- Volunteers
- 44 people
- Sponsor
- Technische Universität Dresden
Normal Tension Glaucoma
Evaluation of PHP-201 Ophthalmic Solution in Patients With Normal Tension Glaucoma
Evaluation of the optimal dose for the efficacy in reduction of intraocular pressure and safety of PHP-201 ophthalmic solution in patients with normal tension glaucoma
- Trial name
- NCT03106532
- Testing
- PHP-201 0.25% ophthalmic solution, PHP-201 0.5% ophthalmic solution
- Where
- South Korea
- Volunteers
- 119 people
- Sponsor
- pH Pharma
Primary Open Angle Glaucoma, Normal Tension Glaucoma
Relationship Between 24-hour IOP Pattern and the 24-hour Blood Pressure Pattern in Patients With POAG
Interplay between the increasing IOP and decreasing blood pressure (BP) during the 24-hour period, especially in the nocturnal period, may lead to insufficient perfusion pressure of the optic nerve and contribute to the…
- Trial name
- NCT01769521
- Testing
- Sensimed Triggerfish®
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Sensimed AG
Normal Tension Glaucoma (NTG), Low-Tension Glaucoma, Bilateral
Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG)
Qlaris' Phase 2 clinical trial investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in normal tension glaucoma patients.
- Conditions
- Normal Tension Glaucoma (NTG), Low-Tension Glaucoma, Bilateral, Low-Tension Glaucoma, Unspecified Eye, Glaucoma
- Trial name
- Nightingale (NCT06030193)
- Testing
- QLS-111 ophthalmic solution (0.015%), Timolol Maleate PF 0.5% Ophthalmic Solution (Timolol)
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Qlaris Bio, Inc.
Glaucoma, Glaucoma, Open Angle
Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments.
The purpose of this study is to evaluate the relationship between intraocular pressure and central corneal thickness using various instruments in ocular hypertension, normal-tension glaucoma, primary open angle glaucoma…
- Conditions
- Glaucoma, Glaucoma, Open Angle, Ocular Hypertension, Keratoconus
- Trial name
- NCT00347191
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Aston University
Open Angle Glaucoma, Normal Tension Glaucoma
Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins
Retinal ischemia is thought to play an important role in the pathogenesis of glaucoma. Recent findings have confirmed that there is a direct correlation between the levels of venous oxygen saturation and the degree of the…
- Trial name
- NCT01794442
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Normal Tension Glaucoma
A New View of Normal Tension Glaucoma: Autoregulation and Systemic Blood Pressure
The objective of this study is to determine whether systemic blood pressure in the body is related to the development and progression of normal tension glaucoma in the eye.
- Trial name
- NCT00706056
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Weill Medical College of Cornell University
Normal Tension Glaucoma
Measurement of the Effect of Gingko Biloba Extract on Ocular and Nailfold Blood-flow in NTG
The purpose of this study is to evaluate the effect of Ginkgo biloba extract (GBE) on the number of blood vessels in the back of the eye as well as the amount of blood flow at the nailfold(where the fingernail meets the skin) of…
- Trial name
- NCT03761992
- Testing
- Gingko Baloba
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Robert Ritch, MD, LLC.
Low Tension Glaucoma
Observational Study of the Long-term Effect of Latanoprost in Normal Tension Glaucoma
The purpose of this study is to assess the long-term efficacy and safety of latanoprost monotherapy in patients with normal tension glaucoma (NTG) using a prospective, observational design.
- Trial name
- NTG-X-PERT (NCT01209624)
- Volunteers
- 902 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Primary Open-angle Glaucoma, Low Tension Glaucoma
Metabolomics in Surgical Ophthalmological Patients
Metabolomics consists in the study of metabolites in body fluids or tissues. It investigates the consequences of the activity of genes and proteins.
- Trial name
- MISO (NCT03098316)
- Testing
- Metabolomics analysis of patient samples
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Normal Tension Glaucoma (NTG), Glaucoma
DSLT in Normal Tension Glaucoma (NTG) Asian Eyes
The goal of this clinical trial is to evaluate the efficacy of direct selective laser trabeculoplasty (DSLT) or laser treatment in Asian patients with normal tension glaucoma.
- Conditions
- Normal Tension Glaucoma (NTG), Glaucoma, Open Angle Glaucoma (OAG), Glaucoma, Open Angle
- Trial name
- NCT07300852
- Testing
- Direct Selective Laser Trabeculoplasty (DSLT)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ngoc Nguyen Inc.
Open Angle Glaucoma, Normal Tension Glaucoma
Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
- Conditions
- Open Angle Glaucoma, Normal Tension Glaucoma, Healthy
- Trial name
- LSFG Repro (NCT04014933)
- Testing
- LASER SPECKLE FLOWGRAPHY
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obstructive Sleep Apnea Syndrome
Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS)
Obstructive sleep apnea syndrome (OSAS) is a common disease, with a prevalence evaluated between 5 - 7% in the general population.
- Trial name
- NCT00874913
- Testing
- measurement of ocular blood flow
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Glaucoma
Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma
The purpose of this study was to determine the incremental intraocular pressure (IOP) lowering that is achieved when Simbrinza is used adjunctively to Travatan in patients with normal tension glaucoma that may benefit from…
- Trial name
- NCT03150160
- Testing
- brinzolamide 1%/brimonidine 0.2% fixed combination, travoprost 0.004% ophthalmic solution
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Novartis Pharmaceuticals