Clinical trials: Normal Upper Extremity
Rheumatoid Arthritis
Rituximab for the Treatment of Early Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, pain, stiffness, damage, and ultimately loss of joint function.
- Trial name
- NCT00396812
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Psoriatic Arthritis
Psoriatic Oligoarthritis Intervention With Symptomatic thErapy
POISE is a two arm interventional trial nested within a cohort (Trials Within Cohorts or TWiCs design). This tests less aggressive early therapy in patients newly diagnosed with low impact oligoarticular PsA.
- Trial name
- POISE (NCT03797872)
- Testing
- Methotrexate, Sulfasalazine, Leflunomide
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- University of Oxford
Breast Cancer Female, Breast Cancer
Omission of SLNB in Triple-negative and HER2-positive Breast Cancer Patients With rCR and pCR in the Breast After NAST
Currently, axillary surgery for breast cancer is considered as staging procedure that does not seem to influence breast cancer mortality, since the risk of developing metastasis depends mainly on the biological behaviour of the…
- Trial name
- NCT04101851
- Testing
- omission of SLNB
- Where
- 40 sites in Austria, Germany and 2 more
- Volunteers
- 350 people
- Sponsor
- Toralf Reimer, MD PhD
Melanoma
CAcTUS - Circulating Tumour DNA Guided Switch
The stay aims to determine whether switching from targeted therapy to immunotherapy based on a decrease in levels of circulating tumour DNA in the blood, will improve the outcome in melanoma patients.
- Trial name
- CAcTUS (NCT03808441)
- Testing
- ctDNA analysis
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- The Christie NHS Foundation Trust
Itching
Efficacy and Safety of Remo-Wax® Oil (RWO) in Subjects With Isolated Itching of the External Ear Canal
Open, single-arm, non-randomized study to demonstrate the efficacy of Remo-Wax® Oil (abbreviated RWO) in the treatment of isolated itching of the external ear canal and to demonstrate the safety of the product.
- Trial name
- Remo_Itch (NCT05811039)
- Testing
- Remo-Wax® Oil
- Where
- Lithuania
- Volunteers
- 36 people
- Sponsor
- Orion Corporation, Orion Pharma
Soft Tissue Sarcoma
Endostar + GT in Pulmonary Metastases of Soft Tissue Sarcoma
The purpose of this exploratory phase II study is to assess the effectiveness and safety profile of Endostar®(Recombinant Human Endostatin Injection) plus Gemcitabine and Docetaxel in treatment of soft tissue sarcoma patients…
- Trial name
- NCT01812018
- Testing
- Endostar, Gemcitabine, Docetaxel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peng Yuan
Melanoma (Skin)
Interferon Alfa-2b With or Without Radiation Therapy in Treating Patients With Melanoma That Has Metastasized to Lymph Nodes in the Neck, Under the Arm, or in the Groin
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Interferon alfa-2b may interfere with the growth of cancer cells.
- Trial name
- NCT00003444
- Testing
- recombinant interferon alfa, radiation therapy
- Where
- 23 sites in United States
- Volunteers
- 167 people
- Sponsor
- Eastern Cooperative Oncology Group
Mycophenolate Mofetil, Cyclophosphamide
MMF Versus CYC in the Induction Therapy of Pediatric Active Proliferative LN
A prospective, randomized, multicenter, open-label, parallel-arm Study to compare effectiveness of mycophenolate mofetil versus cyclophosphamide in the Induction Therapy of pediatric patients with Active Proliferative Lupus…
- Conditions
- Mycophenolate Mofetil, Cyclophosphamide, Lupus Nephritis
- Trial name
- MyCITS (NCT05495893)
- Testing
- Cyclophosphamide, Mycophenolate Mofetil
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Second Xiangya Hospital of Central South University
Breast Cancer With Bone Metastasis
Safety and Efficacy of Zoledronic Acid in Patients With Breast Cancer With Metastatic Bone Lesions
The objective of this study is to assess the clinical benefit of two different dosing schedules of zoledronic acid in patients with metastatic bone lesions from breast cancer who have already been treated with zoledronic acid for…
- Trial name
- NCT00375427
- Testing
- Zoledronic acid
- Where
- Italy
- Volunteers
- 430 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Brain Metastases
TOPAZ: Tucatinib in COmbination With Pembrolizumab And TrastuZumab in Patients With HER2-Positive Breast Cancer Brain Metastases
This is a single arm, open label trial to assess the safety and efficacy of tucatinib in combination with pembrolizumab and trastuzumab for the treatment of HER2+ breast cancer brain metastases (BCBM).
- Conditions
- Breast Cancer, Brain Metastases, HER2-positive Breast Cancer, CNS Disease
- Trial name
- TOPAZ (NCT04512261)
- Testing
- Tucatinib, Pembrolizumab, Trastuzumab
- Where
- United States
- Sponsor
- Reva Basho
Lupus Erythematosus, Systemic
A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus
This is a Phase II/III open label, single-arm, multicenter, extension study to evaluate the safety and efficacy of rituximab when administered on a scheduled basis every 6 months over the course of 1 year with reassessment of…
- Trial name
- VOYAGER (NCT00381810)
- Testing
- Rituximab, Methylprednisolone, Acetaminophen
- Where
- 11 sites in United States
- Volunteers
- 31 people
- Sponsor
- Genentech, Inc.
Breast Cancer Metastatic, Breast Cancer Stage IV
Detecting Tumor DNA in the Blood of HR+/HER2-low Metastatic Breast Cancer Patients to Find Candidates for T-DXd Therapy
After an initial screening phase to identify patients with persistent blood circulating DNA tumors, patients will be enrolled in the treatment phase that was designed as an open-label, multicentre, phase II study, to test the…
- Trial name
- SAFIR3LibHERty (NCT06680596)
- Testing
- trastuzumab derxutecan
- Where
- 40 sites in France
- Volunteers
- 80 people
- Sponsor
- UNICANCER
Breast Cancer
A Phase I, Single-arm, Open-label, Dose-escalation Study to Evaluate the Safety and Tolerability of Orialpha (BD-C) in Healthy Adult Volunteers
This Phase I clinical study is designed to evaluate the safety and determine the maximum tolerated dose (MTD) of Orialpha (BD-C) in healthy adult volunteers.
- Trial name
- NCT07300202
- Testing
- Orialpha (BD-C) at 0.25 x anticipated therapeutic dose, Orialpha (BD-C) at 0.5 x anticipated therapeutic dose, Orialpha (BD-C) at the anticipated therapeutic dose
- Where
- Vietnam
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oriplantee Company Limited
Sjögren´s Disease
Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden
The purpose of this study is to demonstrate the efficacy and safety of ianalumab (VAY736) 300 mg administered subcutaneously (s.c.) monthly for 52 weeks in adult participants with Sjögren's disease who have high symptom burden.
- Trial name
- THALASSA (NCT07621809)
- Testing
- VAY736
- Where
- 33 sites in United States, Australia and 6 more
- Volunteers
- 570 people
- Sponsor
- Novartis Pharmaceuticals
Lymphedema of Upper Limb, Breast Cancer Related Lymphedema
Effectiveness of Stellate Ganglion Block in Breast Cancer Related Lymphedema
Lymphedema is a condition characterized by generalized or regional accumulation of protein-rich interstitial fluid as a result of impaired lymphatic circulation due to congenital or acquired disorders.
- Trial name
- NCT04165512
- Testing
- bupivacaine and triamcinolone
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Marmara University
Nerve Sheath Tumor
Phase II Study of FCN-159 in NF2 Nerve Sheath Tumors
The goal of this clinical trial is to evaluate the efficacy and safety of FCN-159 in patients with specific NF2-associated nerve sheath tumors.
- Trial name
- NCT06553365
- Testing
- FCN-159
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Leucogen, Ribociclib
the Efficacy of Leucogen in Preventing the Risk of Ribociclib-Associated Neutropenia in Early Breast Cancer
This study is a multicenter, single-arm, open-label Phase II exploratory clinical trial designed to evaluate whether prophylactic use of leucogen can reduce the incidence of Grade 3 or higher neutropenia in early-stage HR+/HER2…
- Conditions
- Leucogen, Ribociclib, Neutropenia (Low White Blood Cell Count), Breast Cancer
- Trial name
- NCT07380646
- Testing
- Treat Regimen
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Metastatic Breast Cancer
A Study of Trastuzumab Emtansine (Trastuzumab-MCC-DM1) Administered Intravenously to Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer
This was a multi-institutional, open-label, single-arm, Phase II study of trastuzumab emtansine (T-DM1) administered by intravenous (IV) infusion to patients with human epidermal growth factor receptor 2 (HER2)-positive…
- Trial name
- NCT00509769
- Testing
- Trastuzumab emtansine [Kadcyla]
- Where
- 40 sites in United States
- Volunteers
- 112 people
- Sponsor
- Genentech, Inc.
Triple Negative Breast Cancer
A Study to Evaluate the Efficacy and Safety of SG001 in Combination With Nab-Paclitaxel in Patients With Advanced Triple-Negative Breast Cancer (TNBC)
This is a single-arm, open-label, multicenter, phase II study to evaluate the efficacy and safety of SG001 in combination with Nab-paclitaxel in patients with advanced TNBC.
- Trial name
- NCT05068141
- Testing
- SG001, Nab-paclitaxel
- Where
- China
- Volunteers
- 79 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Arm Lymphedema After Breast Cancer
Compression Bandaging and Manual Lymph Drainage in Women With Lymphedema
Lymphedema is the result of accumulation of fluid and other elements in tissue spaces because of an imbalance between the production of fluid interstitial and transport.
- Trial name
- LYMPHATIC (NCT02165696)
- Testing
- Multimodal treatment: compression bandaging and manual lymph drainage., Manual lymph drainage
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Malaga