Clinical trials: Normal Weight, open to volunteers
Breast Cancer Risk, Cardiovascular Disease Risk
The RISC Registry--Risk Informed Screening Registry
Chronic diseases such as heart disease, cancer, and diabetes are the leading causes of death and disability in the United States. Six in ten adults have one chronic disease; 4 in 10 have two or more.
- Conditions
- Breast Cancer Risk, Cardiovascular Disease Risk, Cardiometabolic Risk, Diabetes
- Trial name
- RISC (NCT05848856)
- Testing
- Breast Cancer, Cardiometabolic, Cardiovascular Risk Screening and Follow up
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Precision Health Equity Initiative
Obesity & Overweight, Normal Weight Adults
Long-term Iron Absorption and Loss in Women
Obese people typically have chronic low-grade inflammation. Based on short-term studies, this inflammation could affect the absorption, utilization, storage, and mobilization of iron, and individuals with inflammation might…
- Trial name
- NCT07855939
- Where
- Thailand
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis
Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin…
- Conditions
- Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis, Chronic Inflammation
- Trial name
- NCT04232566
- Testing
- Bariatric surgery
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Weight Loss
A Study to Evaluate the Pharmacokinetics of HRS9531 Injection in Participants With Mild, Moderate, and Normal Hepatic Function
This is a Phase I clinical study to compare the pharmacokinetics (PK) of HRS9531 Injection in participants with mild/moderate hepatic impairment and participants with normal hepatic function, and to evaluate the safety of HRS9531…
- Trial name
- NCT07540754
- Testing
- HRS9531 Injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Breast Neoplasms, Artificial Intelligence (AI)
Non-Contrast Breast MRI Diagnosis and Risk Stratification Using DWI-Generated Synthetic Contrast Enhancement
This study is conducted under the ethics-approved project titled "Artificial Intelligence Solution for Simplifying the Diagnostic Workflow of Breast MRI''.The goal of this observational study is to develop an integrated breast…
- Conditions
- Breast Neoplasms, Artificial Intelligence (AI), Magnetic Resonance Imaging (MRI), Diffusion Magnetic Resonance Imaging
- Trial name
- NCT07598084
- Testing
- Non-contrast breast MRI diagnostic model
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Overweight and Obesity, Metabolic Syndrome
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans.
- Trial name
- EAT 2 (NCT04583514)
- Testing
- Control, Overfeeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Insulin Sensitivity
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity.
- Conditions
- Obesity, Insulin Sensitivity, Muscle Weakness, Adiposity
- Trial name
- NCT06129110
- Testing
- Diet Weight Loss
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabete Type 2, Insulin Resistant Diabetes (Mellitus)
Study Evaluating the Safety and Feasibility of Endoscopic Duodenal Injections of Autologous Mesenchymal Stem Cells
Type 2 Diabetes Mellitus (T2DM) pathogenesis increasingly involves "diabetic duodenopathy," characterized by proximal intestinal immune and epithelial dysregulation.
- Conditions
- Diabete Type 2, Insulin Resistant Diabetes (Mellitus), Obesity
- Trial name
- STEM-DM (NCT07344324)
- Testing
- endoscopic duodenal injection of ADMSCs
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Laxity; Skin
Evaluate the Safety and Efficacy of AGE Serum in Post-menopausal Patients on Hormone Replacement Therapy Taking Glucagon-like Peptide-1 Agonist
The primary objective is to assess the safety and efficacy of the AGE Serum in improving the appearance of skin in post-menopausal subjects on HRT and non-HRT who are takingGLP-1 agonist therapy through the use of investigator…
- Trial name
- NCT07558603
- Testing
- On GLP1 plus HRT, On GLP1 Only
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Childhood Obesity, Insulin Resistance
Leipzig Adipose Tissue Childhood Cohort
In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents.
- Trial name
- NCT02208141
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Fetal Developmental Abnormality, Fetal Development
Scottish Advanced Fetal Research Study
In-utero exposure to drugs and chemicals through maternal smoking, alcohol use, drug abuse, prescription medicines and occupational/lifestyle exposures is widespread.
- Conditions
- Fetal Developmental Abnormality, Fetal Development, Human, Life Style
- Trial name
- SAFeR (NCT04613583)
- Testing
- SAFeR fetuses
- Where
- United Kingdom
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Diabetes Mellitus, Type 2, Diabetes
Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
This study is to investigate how adipocyte (fat cell) function and fat distribution differ between individuals with normal-weight type 2 diabetes (NWD), those with overweight type 2 diabetes (OWD), and normal-weight controls…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes, Type 2 Diabetes, Pre Diabetes
- Trial name
- NCT06657209
- Testing
- Insulin resistance testing, OGTT, Fat biopsy
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Stanford University
Normal Healthy Adults
A Research Study to Evaluate BLX-0871 in Healthy Adults
This study will test an oral medicine called BLX-0871, which is being developed to improve metabolic health by activating AMP-activated protein kinase (AMPK), a key regulator of energy balance.
- Trial name
- NCT07140081
- Testing
- BLX-0871
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biolexis Therapeutics
Normal-weight Obesity
The Interaction of Body Composition, Sex Hormones and Exercise in Men
The overall objective of this project is to advance understanding of the causes of normal weight obesity (NWO) in men, namely the hormone profile and related potential mediating mechanisms, and the efficacy of different modes of…
- Trial name
- AHA-NWO (NCT06970457)
- Testing
- Resistance Exercise Training, Aerobic Exercise Training
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Obesity
Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.
Glucagon like peptide (GLP-1) agonists, such as liraglutide, exenatide, and semaglutide, have been increasingly used as a medication to address the current twin epidemics of diabetes and obesity.
- Trial name
- NCT05419726
- Testing
- Semaglutide Injectable Product (not provided by the study)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Obesity, Vascular Dysfunction
DNA Methylation and Vascular Function
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for…
- Trial name
- NCT03527420
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Normal Healthy Volunteer, Safety After Oral Intake
A Research Study to Evaluate BLX-7006 in Healthy Adults
This study will test an oral medicine called BLX-7006, which acts like the hormone Glucagon-like Peptide-1 (GLP-1) to help control blood sugar and body weight. Current GLP-1 medicines are given by injection.
- Trial name
- NCT07140055
- Testing
- BLX-7006
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biolexis Therapeutics
ROSAH Syndrome, Anhidrosis
A Method Characterization Study to Evaluate Thermoregulatory Sweat Production in Healthy Volunteers and Patients With ROSAH Syndrome)
This study is designed to characterize a new quantitative method for measuring sweat production induced by controlled heat exposure. Approximately 20 healthy volunteers and up to 10 patients with ROSAH syndrome will be enrolled.
- Conditions
- ROSAH Syndrome, Anhidrosis, Hypohidrosis
- Trial name
- NCT07814209
- Testing
- Standardized Controlled Heat Exposure With Gravimetric Sweat Collection
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Class I Obesity
Trial of Innovative Fat-loss Focused Approaches in Patients With Class I Obesity: a Comparative Study
This single-center randomized comparative study is designed to compare the effectiveness of tirzepatide and transcutaneous low-frequency auricular vagus nerve stimulation in adults with class I obesity and without chronic…
- Trial name
- TIFFANY (NCT07866183)
- Testing
- Tirzepatide, Transcutaneous auricular vagus nerve stimulation
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine