Clinical trials: Normal Weight, active
Overweight , Obesity, Prediabetes
Smartwatch-based Intervention for Cardiovascular Health (SWITCH)
This study aims to employ a cluster randomized controlled trial to evaluate the effectiveness of an mHealth-Based Multi-faceted Cardiovascular Health Intervention Model among metabolically at-risk people with overweight/obesity…
- Conditions
- Overweight , Obesity, Prediabetes, High-normal Blood Pressure, Borderline Elevated Blood Lipids
- Trial name
- NCT07372729
- Testing
- Smartwatch-Based Multi-Faceted Behavioral Intervention Model Led by Exercise and Dietary Interventions, Supported by Primary Medical Staff, Along with the Distribution of Health Education Manuals, Face-to-face health education sessions
- Where
- 3 sites in China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Glioblastoma
PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma
This phase III trial compares pH weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI)-based surgical resections to standard of care surgical resections for the treatment of patients with…
- Trial name
- NCT06448286
- Testing
- Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Contrast-enhanced Magnetic Resonance Imaging, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Paracetamol, Cefazolin
Paracetamol and Cefazolin Pharmacokinetics in Normal Weight and Overweight Children
Pharmacokinetic evaluations will be conducted to characterize the cefazolin plasma concentration-time profile, cefazolin penetration into subcutaneous adipose tissue, and paracetamol metabolization as assessed through blood…
- Trial name
- TISSUE (NCT07585487)
- Testing
- Cefazolin, Paracetamol (drug)
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Ghent
Breastfeeding, Breastfeeding Education
Improved Child Nutrition and Development Through Social Transfers
The goal of this clinical trial is to learn if a conditional social transfer works to improve rates of complementary breastfeeding.
- Conditions
- Breastfeeding, Breastfeeding Education, Breastfeeding Duration, Breastfeeding Continuation
- Trial name
- TENDER (NCT07569172)
- Testing
- Social Transfer
- Where
- Côte d’Ivoire
- Volunteers
- 1,040 people
- Sponsor
- Swiss Tropical & Public Health Institute
Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma
Breast Cancer WEight Loss Study (BWEL Study)
This randomized phase III trial compares whether weight loss in overweight and obese women may prevent breast cancer from coming back (recurrence).
- Conditions
- Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7
- Trial name
- NCT02750826
- Testing
- Health Education Program, Weight Loss Intervention
- Where
- 1,498 sites in United States, Canada and 2 more
- Volunteers
- 3,177 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer
Impact of Intermittent Fasting on Biomarkers of Inflammation and Health-Related Quality of Life: A Feasibility Trial for Women With HR+/HER2- Early Breast Cancer
This single-arm study is designed to test the hypothesis that a six-month intermittent fasting (IF) intervention is feasible for patients to adhere to and improves health-related quality of life while subjects are on adjuvant…
- Trial name
- NCT06106477
- Testing
- Intermittent Fasting
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Normal Weight Obesity, Metabolically Obese Normal Weight
Metabolic Obesity in Normal Weight (MONW): Diagnostic Markers Stud
Metabolically Obese Normal Weight (MONW) represents a phenotype affecting individuals with a normal Body Mass Index (BMI) but characterized by excessive adipose tissue accumulation.
- Conditions
- Normal Weight Obesity, Metabolically Obese Normal Weight, Metabolic Syndrome
- Trial name
- NCT07358533
- Where
- Poland
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Obesity
Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity
The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific…
- Trial name
- NCT07031297
- Testing
- Meal Study
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Low Back Pain in Obese Patients After Important Weight Loss
Prospective Study on the Consequences of Weight Loss After Bariatric Surgery on Obese Patients' Spine.
The purpose of this study is to determine how an important weight loss after bariatric surgery affects obese patients ' spine, and the effects it has on low back pain, sagittal alignment and lipomatosis .
- Trial name
- SPINOB (NCT04893954)
- Testing
- Full Spine Radiography, Lumbar spine MRI
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Overweight and Obesity
Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity
Obesity, affecting 40% of US adults and costing 173b annually, represents a significant health care burden (1). It is associated with increased risk for multiple chronic diseases including hypertension, type 2 diabetes (T2D)…
- Conditions
- Obesity, Overweight and Obesity, Overweight
- Trial name
- NCT05912621
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stanford University
Glioblastoma, Anaplastic Astrocytoma
Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma
The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma will help improve the radiation…
- Conditions
- Glioblastoma, Anaplastic Astrocytoma, Astrocytoma, Anaplastic Oligodendroglioma
- Trial name
- NCT06108206
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Breast Cancer
Non-contrast DWI for Supplemental Screening
Diffusion-weighted imaging (DWI) is a short (under 5 minutes) non-contrast MRI technique that has shown promise for the detection and characterization of breast cancer.
- Trial name
- NCT03607552
- Testing
- Non-contrast DWI, Non-contrast MRI
- Where
- 2 sites in United States
- Volunteers
- 269 people
- Sponsor
- University of Washington
Mood, Eating Patterns
The Effect of Portion Sizes on Mood
The purpose of this study is to investigate whether different portion sizes will effect overall mood.
- Trial name
- NCT01725425
- Testing
- Control, Increase Portion Size, Decrease Portion Size
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Ultrasound, Sarcopenia
Muscle Quality and Subcutaneous Adipose Tissue in the Rectus Femoris and Rectus Abdominis Muscles: Ultrasound Evaluation and Functional Correlation in Older Adults
The goal of this observational, cross-sectional study is to examine the relationship between body composition and muscle quality in women over the afe of 65.
- Conditions
- Ultrasound, Sarcopenia, Obesity
- Trial name
- NCT07069777
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Salamanca
Perinatal and Neonatal Outcomes in Pregnancies With Type 2 Diabetes Mellitus (T2DM)
Antenatal Myo-inositol Supplementation in Pre-existing Diabetes
This feasibility pilot study aims to gather data that can guide the design of a larger, more comprehensive trial to establish the effects of myo-inositol supplementation on supporting healthy outcomes in pregnancies complicated…
- Trial name
- AMulet (NCT07241221)
- Testing
- Myo-inositol and folic acid supplement, Folic acid supplement
- Where
- Singapore
- Volunteers
- 182 people
- Sponsor
- National University Hospital, Singapore
MASLD
Hepatic Gene Response to Intravenous Glucose in Obese Patients With and Without MASLD Undergoing Bariatric Surgery
The goal of this clinical trial is to learn how the liver responds to sugar in people with obesity who are having bariatric surgery.
- Trial name
- GHAST (NCT07326865)
- Testing
- [6,6-D2]-labeled glucose (intravenous), Saline (0.9% sodium chloride infusion)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Overweight and Obesity, Hyperandrogenemia
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
The investigators will measure plasma concentrations of the hormones insulin and testosterone as well as measures of insulin sensitivity in women with overweight or obesity who have insulin resistance (IR).
- Conditions
- Overweight and Obesity, Hyperandrogenemia, Insulin Resistance
- Trial name
- WAIST (NCT06998238)
- Testing
- Mediterranean-based, carbohydrate restricted, calorie reduced diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Prediabetes, Impaired Fasting Glucose
Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)
Prediabetes affects millions of adults worldwide and carries a high risk of progression to type 2 diabetes. Mazdutide is a once-weekly injectable drug that activates both GLP-1 and glucagon receptors, lowering blood sugar and…
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DREAM-PRE (NCT07654062)
- Testing
- Mazdutide, Standardized Lifestyle Intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shandong Provincial Hospital
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University