Clinical trials: Normobaric Hypoxia
Hypoxia, Altitude
The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males
Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal…
- Trial name
- NCT06204731
- Testing
- Exercise and environmental conditions
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Multiple Sclerosis
Normobaric Hypoxic Training and Multiple Sclerosis
To study the effects of normobaric hypoxic training on cardiorespiratory fitness, resting, postprandial and exercise activity energy expenditure, immunoregulatory functions and serum erythropoietin levels in relapsing-remitting…
- Trial name
- MS_EPOXI (NCT02509897)
- Testing
- Hypoxic training, Normoxic training
- Where
- Germany
- Volunteers
- 39 people
- Sponsor
- Charite University, Berlin, Germany
Baro-reflex Sensitivity, Heart Rate Variability
Low Intensity Exercise in Different Normobaric/Hypobaric Normoxic/Hypoxic Conditions.
The main goal of this project is to investigate how low intensity cycling exercise (1.5W/kg, for 6 minutes) influences cerebral functions, such as: Cerebral blood flow, oxygenation, and other physiological variables in different…
- Conditions
- Baro-reflex Sensitivity, Heart Rate Variability, EEG, Microstates, Cerebral Blood Flow Regulation
- Trial name
- Hypoxia (NCT03439202)
- Testing
- Hypoxia
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fliegerärztliches Institut
Metabolic Syndrome
Normobaric Hypoxic Training and Metabolic Syndrome
The patient numbers with metabolic syndrome and diabetes have doubled in the last decade. Data that physical exercise ameliorates the metabolic syndrome are convincing, although the mechanisms of the effect in man are not clear.
- Trial name
- NCT01468220
- Testing
- Endurance training
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- Charite University, Berlin, Germany
Pulmonary Hypertension
Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension
Pulmonary Hypertension (PH) is a severe disease with a bad prognosis. However, thanks to extensive research in this field, there are more and better treatment options that allow patients to participate in recreational activities…
- Trial name
- NCT03195959
- Testing
- Hypoxia and Hyperoxia
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- University of Zurich
Healthy Men and Women
Metabolic Dynamics During Physical Activity
The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on…
- Trial name
- NCT03485716
- Testing
- running on a treadmill under normoxia or hypoxia
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Aging Well
Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly
Due to age-related effects, the bone and cardiovascular health are damaged. Physical exercise and in particular the strength training has been proposed as a fundamental tool to these pathologies, especially in the elderly.
- Trial name
- NCT04281264
- Testing
- Passive Hypoxia, Normoxia Circuit Training with Elastic Bands, Hypoxia Circuit Training with Elastic Bands
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Hypertension, Pulmonary
Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension
To study hemodynamic effects of acute normobaric hypoxia during exercise in patients with pulmonary hypertension in a single-center randomized controlled trial.
- Trial name
- HEXA (NCT04697875)
- Testing
- Normobaric hypoxia (FiO2 15%)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Executive Function (Cognition), Normobaric Hypoxia
Effect of Intermittent Normobaric Hypoxia on Executive Functions
The main objective of this study was to analyze the effects of an intermittent normobaric hypoxia session on executive functions assessed with different cognitive tests given to healthy young subjects.
- Trial name
- NCT07027410
- Testing
- Intermittent normobaric hypoxia, Normoxia
- Where
- 2 sites in Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Obesity & Overweight, Fat Mass
High-Intensity Interval Training in Low Versus Normal Oxygen: Effects on Body Fat and Gut Health in Adults Aged 50-75 With Overweight or Obesity (HYPOXFAT)
Overweight and obesity are major public health challenges worldwide, and their prevalence increases with age, partly because of age-related metabolic and hormonal changes.
- Trial name
- HYPOXFAT (NCT07796971)
- Testing
- Hypoxic High-Intensity Interval Training, Normoxic High-Intensity Interval Training
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Caffeine, Hypoxia
Caffeine and Hypoxia During Exercise in Males and Females
Several high-altitude destinations recommend their visitors to avoid caffeine, theoretically due to the associated diuresis which could contribute to acute mountain sickness.
- Trial name
- HypoCaff (NCT05764018)
- Testing
- Caffeine, Hypoxia, Normoxia
- Where
- Slovenia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Glucose
The Effects of Normobaric Hypoxia on Blood Glucose Levels.
The purpose of this research study is to observe whether there is a change in blood glucose levels in response to a 2 hour oral glucose tolerance tests (OGTT) during acute normobaric hypoxia (short term low oxygen levels at…
- Trial name
- NCT01302782
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Normobaric Hypoxia
Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Altitude training has been suggested to be of potential support to improve some chronic clinical conditions, especially metabolic conditions.
- Trial name
- HYPOMASLD (NCT07073326)
- Testing
- HYPOTRAIN, NORMOTRAIN
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- University of Trieste
Normobaric Hypoxia, Hypoventilation
"Living Low - Training High" Methods and Physiological Responses in Well-trained Swimmers
To overcome the lack of knowledge regarding the impact of different "living low, training high" methods on swimming performance, a 4-week intervention will be carried out to determine and compare the effects of three Repeated…
- Conditions
- Normobaric Hypoxia, Hypoventilation, Normoxia
- Trial name
- NCT06253039
- Testing
- Repeated sprint
- Where
- Portugal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Hypoxia, Altitude, Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Altitude, Hypoxia, Normobaric Hypoxia, Right Ventricular Function
- Trial name
- RIVER-Asthma (NCT07431580)
- Testing
- Normobaric Hypoxia
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Mona Lichtblau
Hypoxia, Brain
CO2 (Carbon Dioxide) - Cerebral Oxygenation
Several projects in high altitude research in environments with a low oxygen partial pressure (hypobaric hypoxia) leading to hypoxemia showed, that cerebral perfusion and cerebral performance could be improved by adding C02…
- Trial name
- NCT03338907
- Testing
- Oxycarbon (5% CO2+ 95% O2)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Hypertension, Pulmonary
Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension
To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension on blood markers (serum markers of iron and red blood cell homeostasis and micro-RNAs known to be associated with PH).
- Trial name
- HEXABM (NCT04715113)
- Testing
- Normobaric hypoxia (FiO2 15%), Normobaric hypoxia (FiO2 15%) under Sildenafil
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Type2 Diabetes
The Effect of Hypoxia on Type 2 Diabetes and Weight Loss
The number of people with type 2 diabetes mellitus (T2DM) continuing to rise, this pandemic is expected to reach 700 million people by 2045.
- Trial name
- NCT05147116
- Testing
- Sleeping in a tent
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Portsmouth
type1diabetes
Physical Exercise in Normobaric Hypoxia and Normoxia in Type 1 Diabetic Patients
Physical activity, along with proper nutrition, is the basis for the behavioral treatment of diabetes. In recent years exercise training in normobaric hypoxia is used in training programs for athletes and in rehabilitation.
- Trial name
- NCT04450745
- Testing
- Exercise in hypoxia, Exercise in normoxia
- Where
- Poland
- Volunteers
- 16 people
- Sponsor
- Silesian Centre for Heart Diseases
Altitude Hypoxia, Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Altitude Hypoxia, Hypoxia, Normobaric Hypoxia, Right Ventricular Function
- Trial name
- RIVER-HAPE (NCT07431554)
- Testing
- Normobaric Hypoxia
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Mona Lichtblau