Clinical trials: Normotensive
Pressor Response, Baroreflex Sensitivity
High Resolution Phenotyping in Healthy Humans
Baroreflex sensitivity is integral to blood pressure regulation, and varies among healthy, normotensive individuals. A reduced compensatory ability of baroreflex buffering in patients with carotid denervation results in blood…
- Conditions
- Pressor Response, Baroreflex Sensitivity, Blood Pressure Variability, Heart Rate Variability
- Trial name
- NCT00943774
- Testing
- Physiological maneuvers
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Intubation, Intratracheal
The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation in Normotensive and Hypertensive Patients
To find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in normotensive and hypertensive patients
- Trial name
- NCT01880931
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Severance Hospital
Blood Pressure, Contraception
Contraceptives Containing Drospirenone and Blood Pressure
Background: Drospirenone (DRSP) seems to have a favorable effect on blood pressure (BP); however, when associated with ethinylestradiol (EE), this effect does not seem to occur.
- Trial name
- NCT02342093
- Testing
- 30EE+DRSP, 20EE+DRSP
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Tocolysis With Nifedipine
Changes in Central Arterial Pressure of Normotensive Women Taking Nifedipine for Tocolysis
To determine the central blood pressure changes in normotensive women who are receiving nifedipine for uterine contraction suppression
- Trial name
- NCT02902354
- Testing
- Nifedipine for tocolysis
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Louis University
Healthy Normotensive Volunteers
Chronopharmacology of Valsartan in Normotensive Subjects
The choice of drug administration time may affect the pharmacokinetics and/or drug response, and knowledge of any such circadian rhythm-dependent effects may help to reduce side effects or to enhance efficacy.
- Trial name
- NCT02631031
- Testing
- Valsartan
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma
Testing a Reading Module to Improve Reading Skills and Quality of Life in Glaucoma Patients
The goal of this interventional study is to test the effectiveness of reading rehabilitation module towards reading speed and error, and quality of life in glaucoma patients.The main questions it aims to answer are: 1.
- Conditions
- Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma, Normotensive Glaucoma, Primary Angle Closure Glaucoma
- Trial name
- NCT07741812
- Testing
- Reading Rehabilitation Module
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sains Malaysia
Pulmonary Embolism
Validation of Different Risk Assessment Strategies in Normotensive Pulmonary Embolism
A risk stratification in hemodynamically stable patients with acute pulmonary embolism (PE) is deemed necessary to guide patient management.
- Trial name
- NCT02843243
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Azienda Ospedaliera Cosenza
Pre Hypertension
Combined Effects of Isometric Wall Squats and High Intensity Interval Training on Rate Pressure Product in Normotensive and Pre-hypertensive Sedentary Adults
Hypertension is leading yet preventable risk factor for cardiovascular disease and all-cause mortality worldwide. Prehypertension identifies those at high risk of developing HTN, prompting intervention to prevent or delay the…
- Trial name
- NCT06610006
- Testing
- High Intensity Interval Training (HIIT), Isometric Wall Squat
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Hypertension
Flaxseed Lignan Supplementation in Elderly Participants With Stage I Hypertension
Current recommendations today suggest that use of therapeutic lifestyle changes, such as supplementation with specific dietary components and moderate exercise, are appropriate interventions for individuals with borderline high…
- Trial name
- NCT02391779
- Testing
- BeneFlax®, Walking training, Flexibility training
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Normotensive, Obstructive Sleep Apnea
Normotensive OSA Patients With Nondipper Circadian Blood Pressure Pattern
The principal objective is to evaluate the effect of CPAP treatment on blood pressure (BP) in normotensive patients with nondipper circadian pattern with sleep apnea-hypopnea syndrome (SAHS).
- Trial name
- Nondipper-OSA (NCT03987425)
- Testing
- CPAP treatment
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Blood Pressure, Endothelial Dysfunction
Novel Time-efficient Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure
Above-normal systolic blood pressure (SBP), defined as SBP >/= 120 mmHg, is the major modifiable risk factor for cardiovascular disease, stroke, cognitive decline/dementia, and other chronic health problems.
- Conditions
- Blood Pressure, Endothelial Dysfunction, Hypertension
- Trial name
- NCT04848675
- Testing
- Inspiratory muscle strength training, Brisk walking
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Newly Diagnosed Type 2 Diabetes, Coronary Artery Disease
Sitagliptin Reduces Left Ventricular Mass in Normotensive Type 2 Diabetic Patients With Coronary Artery Disease
Cardiovascular complications account for the highest mortality in type 2 diabetic patients, mainly due to coronary artery disease (CAD).Left ventricular hypertrophy (LVH) is widespread in type 2 diabetic patients with CAD, even…
- Trial name
- NCT01863147
- Testing
- Sitagliptin and acarbose
- Where
- 2 sites in China
- Volunteers
- 66 people
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Aging, Blood Pressure
Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
High blood pressure (BP) is the major modifiable risk factor for cardiovascular diseases (CVD) and related health conditions, particularly among postmenopausal (PM) women.
- Conditions
- Aging, Blood Pressure, Endothelial Dysfunction, Hypertension
- Trial name
- NCT05000515
- Testing
- High-resistance inspiratory muscle strength training, Aerobic exercise
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Diabetes Mellitus, Type 2, Blood Pressure
Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes-----renal Substudy
Lowering of blood pressure (BP) in high-risk hypertensive individuals reduces major adverse cardiovascular (CV) and renal events. Diabetic patients with hypertension benefit from BP lowering treatment.
- Trial name
- NCT04978649
- Testing
- Allisartan Isoproxil, Amlodipine
- Sponsor
- Guangdong Provincial People's Hospital
Pre-hypertension, Hypertension
Effects of the Beta-blocker Nebivolol (Bystolic) on Subjects With High Normal Blood Pressure and/or a Family History of Hypertension
The investigators aim to evaluate subjects at high risk of future development of hypertension, those with a family history of hypertension and/or that already have high normal(SBP 120-139 mmHg or DBP 80-89 mmHg) blood pressure.
- Trial name
- NCT01202175
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Hypertension,Essential
Brain BOLD fMRI in Hypertensive and Normotensive Participants
This study will explore the brainstem activity in response to stress in hypertensive patients and normotensive subjects. In addition, it will evaluate if the response in hypertensive patients can be modulated by blocking the…
- Trial name
- BRAIrdN (NCT03473275)
- Testing
- Cold Pressor test, PinPrick test
- Where
- Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sleep Apnea, Obstructive
Effect of CPAP vs Control on Nocturnal Dipping in Normotensive Patients With Obstructive Sleep Apnea
This is an open-label, parallel, prospective, randomised control trial evaluating the effect of Continuous Positive airway pressure (CPAP), the standard treatment for obstructive sleep apnea (OSA) versus control (diet and…
- Trial name
- NCT04938128
- Testing
- CPAP
- Where
- Ireland
- Sponsor
- St Vincent's University Hospital, Ireland
Healthy Normotensive Participants
Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide (Double Doses)
This study was conducted to compare the rate and extent of absorption of valsartan and hydrochlorothiazide. To maximize the possibility of finding drug-drug interactions, the dose of valsartan and hydrochlorothiazide was doubled…
- Trial name
- PKVH PART II (NCT01767298)
- Testing
- Valsartan/Hydrochlorothiazide, Valsartan, Hydrochlorothiazide
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Autosomal Dominant Polycystic Kidney Disease
Assessment of Longitudinal Changes in Endothelial Function and Oxidative Stress in Normotensive Patients With ADPKD
The purpose of this study is to determine whether patients with autosomal dominant polycystic kidney disease (ADPKD) present with abnormal endothelial function, increased levels of NOX4 activity and mitochondrial abnormalities…
- Trial name
- NCT03493802
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pre-Eclampsia
Serpin C and Soluble Fms-like Tyrosine Kinase-1 Levels in Normotensive Pregnant Women May Predict the Development of Preeclampsia
Evaluation of the predictability of estimated levels of Serpin C, sFlt-1 and placental growth factor (PLGF) in blood samples obtained during the 1st trimester from normotensive pregnant women for identification of women liable to…
- Trial name
- NCT06214702
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University