Clinical trials: Normothermia
Malignant Peritoneal Mesothelioma, Peritoneal Mesothelioma
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
The purpose of this study is to find out whether intraperitoneal or intravenous chemotherapy given after cytoreductive surgery and HIPEC are effective treatments for people with malignant peritoneal mesothelioma.
- Conditions
- Malignant Peritoneal Mesothelioma, Peritoneal Mesothelioma, Mesothelioma, Mesothelioma, Malignant
- Trial name
- NCT06057935
- Testing
- Pemetrexed, Cisplatin, Carboplatin
- Where
- 13 sites in United States
- Volunteers
- 64 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Liver Transplantation
OrganOx Metra® New Enrollment PAS
The objective of the OrganOx metra® New Enrollment Post-Approval Study is to collect data on the post-transplant clinical outcomes of DBD and DCD donor livers preserved and assessed on the OrganOx according to the current…
- Trial name
- NCT05526326
- Testing
- Transplant with normothermic machine perfused (NMP) donor liver
- Where
- 10 sites in United States
- Volunteers
- 315 people
- Sponsor
- OrganOx Ltd.
Stroke
Prehospital COOLing 1 (PreCOOL 1)
Elevated body temperature was shown to be associated with worse outcome in acute stroke patients. PreCOOL 1 aims to investigate efficacy, feasibility and safety of prehospital cooling with cold infusions in stroke patients.
- Trial name
- PreCOOL (NCT01669408)
- Testing
- Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Heidelberg
Kidney Transplant; Complications, Kidney Failure
Normothermic Machine Perfusion (NMP) Versus Static Cold Storage (SCS) in Human Kidney Transplantation
Due to organ shortage in kidney transplantation (KT) several strategies have been implemented in an attempt to increase donor pool utilization, including transplantation of extended criteria donor (ECD) allografts.
- Conditions
- Kidney Transplant; Complications, Kidney Failure, Graft Dysfunction
- Trial name
- NMP-DBD (NCT05031052)
- Testing
- End-ischemic normothermic oxygenated machine perfusion, Static cold storage
- Where
- 4 sites in Germany
- Volunteers
- 194 people
- Sponsor
- Charite University, Berlin, Germany
Surgical Site Infection
Effect of Standard Normothermia Protocol On Surgical Site Infections
Aim of this study is to investigate the efficiency of a standard normothermia protocol and effects on postoperative Surgical Site Infection (SSI) rate.
- Trial name
- NCT02961244
- Testing
- Prewarming and perioperative warming with Forced Air Warming device and its blankets., Forced Air Warming blanket
- Volunteers
- 118 people
- Sponsor
- Dokuz Eylul University
Ovarian Cancer
Normethermic Intraperitoneal Chemotherapy - a Novel Concept for Local Treatment of the Elderly and Fragile Women With Advanced Ovarian Cancer?
The purpose of this feasibility study is to investigate whether NIPEC with carboplatin after surgery is safe for the elderly and frail women with advanced ovarian cancer.
- Trial name
- NICE-C (NCT07733505)
- Testing
- Normethermic Intraperitoneal Chemotherapy with carboplatin
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Hypothermia
The Effect of Using a Thermal Blanket on Temperature and Shivering Levels
The research is planned as a descriptive, cross-sectional, randomized controlled study to evaluate the effect of using thermal blankets on patients' temperature comfort and shivering levels before open heart surgery.
- Trial name
- NCT07505654
- Testing
- Thermal Blanket, Forced Air Warming Blanket
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Trakya University
Cardiac Arrest
Efficacy and Safety of TTM in Adults With ECPR.
Investigators hypothesize that there is a difference in the 30-day survival rate and good neurological outcome rate between two groups of cardiac arrest patients undergoing ECPR, one group receiving hypothermia and the other…
- Trial name
- TTM、ECPR (NCT06608095)
- Testing
- hypothermia group, normothermia group
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Peking University Third Hospital
Liver Transplantation, Liver Diseases
Assessing Declined Liver Grafts With Normothermic Machine Perfusion to Reduce Transplant Waiting Time
The goal of this study is to find out if quality assessment by normothermic machine perfusion can be used to safely increase the number of usable donor livers, helping more people get transplants faster and with better results.
- Conditions
- Liver Transplantation, Liver Diseases, Surgery
- Trial name
- ExTra (NCT06874296)
- Testing
- Quality Assessment with Normothermic Machine Perfusion (NMP)
- Where
- 10 sites in Germany
- Volunteers
- 186 people
- Sponsor
- Charite University, Berlin, Germany
Coronary Disease, Coronary Artery Disease
MACBIS50 in Patients Undergoing CAG During Normothermic CPB Phase.
Background: We determined the minimum alveolar concentration (MAC) of sevoflurane for maintaining bispectral index (BIS) below 50 (MACBIS50) in patients undergoing coronary artery bypass grafting during normothermic…
- Trial name
- NCT02711384
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
End Stage Renal Disease
PROlonged Ex-vivo Normothermic Machine PERfusion for Kidney Regeneration
The investigators would like to introduce and clinically evaluate prolonged normothermic machine perfusion (PNMP) to preserve and assess high-risk donor kidneys prior to transplantation.
- Trial name
- PROPER (NCT04693325)
- Testing
- Prolonged normothermic machine perfusion
- Where
- 2 sites in Netherlands
- Volunteers
- 18 people
- Sponsor
- Leiden University Medical Center
Organ Transplant
Confirming Permanent Lack of Blood Flow to the Brain During A-NRP DCC Organ Transplant
This study aims to evaluate the surgical technique used in Abdominal Normothermic Regional Perfusion (A-NRP) in death determination by circulatory criteria (DCC) organ donors.
- Trial name
- CONCLUDE (NCT05884736)
- Testing
- Neuromonitoring
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Neoplasms
A Study of ADH-1 in Combination With Normothermic Isolated Limb Infusion of Melphalan
N-cadherin, a protein involved in blood vessel cell binding and on the surface of many tumor cells, is increased as cancer progresses. ADH-1 blocks N-cadherin.
- Trial name
- NCT00421811
- Testing
- ADH-1, melphalan
- Where
- 7 sites in United States
- Volunteers
- 56 people
- Sponsor
- Adherex Technologies, Inc.
Hypothermia, Postoperative Pain
Optimal Temperature Control in Body Contouring Procedures
The goal of this clinical trial is to compare different strategies for normothermia prevention in patients undergoing body contouring and other Aesthetic Plastic Surgery procedures.
- Conditions
- Hypothermia, Postoperative Pain, Postoperative Nausea, Postoperative Complications
- Trial name
- NCT06238739
- Testing
- Control - Standard Strategies for hypothermia prevention, Fluid warming before infusion and infiltration, Thermal convection blanket by water flow (Blanketrol)
- Where
- Colombia
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Total Definer Research Group
Liver Transplantation
Secretin in Ex-situ Liver Perfusion
The main objective is to assess whether the use of human synthetic secretin in a clinical (COR-)NMP procedure can restore physiological HCO3- content of the bile during ex-situ NMP.
- Trial name
- NCT07651748
- Testing
- Secretin administration during ex-situ liver machine perfusion
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Normothermia
Perioperative Active Warming Techniques in Colorectal Surgeries
We propose a study in which we compare two intraoperative active warming devices for maintenance of normothermia in patients undergoing colorectal surgery.
- Trial name
- NCT00913978
- Testing
- Group 1: VitaHeat, Group 2: Bair Hugger
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northwestern University
Hypothermia
Study on the Incidence of Perioperative Hypothermia at the Surgical Area of Parc Tauli Hospital Universitari, Sabadell
The study TAULÍ-PREVINQ-WARM will assess the rate of perioperative hypothermia in patients submitted to major surgical procedures at the operating room main area (and at the ambulatory surgery building for ophthalmologic major…
- Trial name
- PREVINQ-WARM (NCT03961620)
- Testing
- The SpotOn system that encompasses the registration unit (3M SpotOn Control Unit), disposable sensor (3M SpotOn Control Sensor) along with the cords and electric power unit.
- Where
- Spain
- Volunteers
- 101 people
- Sponsor
- Corporacion Parc Tauli
Liver Transplantation
Post Static Cold Storage Normothermic Machine Liver Perfusion
The aim of this study is to assess the safety and feasibility of a short period of cold storage prior to normothermic machine perfusion in adult liver transplantation.
- Trial name
- NCT03176433
- Testing
- Normothermic Machine Liver Perfusion
- Where
- 3 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Intracerebral Hemorrhage
Safety and Feasibility Study of Targeted Temperature Management After ICH
Though TTM is ubiquitously used in the neuro-intensive care unit, there is limited experience with the use of TTM after intracerebral hemorrhage (ICH), the most devastating type of stroke.
- Trial name
- TTM-ICH (NCT01607151)
- Testing
- Normothermia, Hypothermia
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Pregnancy
Effect of Maintenance of Intraoperative Normothermia in Cesarean Section on Thermal Comfort, Serum Cortisol and Apgar Score: A Randomized Controlled Trial
Cesarean section is a common method of delivery worldwide today. According to WHO, cesarean section accounts for more than 1 in 5 (21%) of all births, and it is predicted that approximately one-third (29%) of births will be by…
- Trial name
- NCT06962241
- Testing
- Warming group
- Volunteers
- 50 people
- Sponsor
- Kocaeli University