Clinical trials: Nose Bleed
Anterior Epistaxis
Topical 15% Trichloroacetic Acid Versus Silver Nitrate Cauterization in the Management of Idiopathic Childhood Epistaxis: A Prospective Double-Blinded, Randomized Clinical Trial
the invistigators aim to explore the efficacy of trichloroacetic acid as a chemical cauterization agent and compare it with that of silver nitrate in the treatment of idiopathic epistaxis in children.
- Trial name
- Epistaxis (NCT06836791)
- Testing
- chemical cautrizating agents to stop epistaxis, Silver Nitrate, Trichloroacetic Acid Topical
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Youssef Zaki
Epistaxis Nosebleed
Nasal Compression Device Study for Epistaxis
This study will explore how a nasal compression device compares to manual compression for stopping anterior nosebleeds. This will be a non-randomized controlled trial enrolling participants presenting to medical care for anterior…
- Trial name
- NCT05789264
- Testing
- Nasal Compression Device, Routine Care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NasaClip
HHT, Hereditary Hemorrhagic Telangiectasia
Intranasal Bevacizumab for HHT-Related Epistaxis
This is a randomized, controlled, double-blind, placebo-controlled trial of intranasal Avastin (bevacizumab) injection versus saline control for control of HHT-related epistaxis when used in conjunction with bipolar…
- Conditions
- HHT, Hereditary Hemorrhagic Telangiectasia, Epistaxis, Nose Bleeds
- Trial name
- NCT02389959
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis
Topical TOR-582 Treatment of Epistaxis in HHT
People with hereditary hemorrhagic telangiectasia (HHT) often experience frequent and severe nosebleeds that can disrupt daily life and lead to anemia, medical procedures, and reduced quality of life.
- Trial name
- NCT07667413
- Testing
- Topical sirolimus ointment
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Columbia University
Maxillofacial Injuries, Nasal Bleeding
Comparison Between Nasal and Oropharyngeal Bleeding in Video Laryngoscopy and Direct Laryngoscopy for Nasal Intubation
The objective of this study is to compare the effectiveness and safety of video laryngoscopy versus direct laryngoscopy for nasal intubation in patients with maxillofacial fractures regarding less bleeding to oral and nasal…
- Conditions
- Maxillofacial Injuries, Nasal Bleeding, Intubation Complication
- Trial name
- NCT06386757
- Testing
- Combined Video Laryngoscopy (VL) and Bougie, Combined Direct Laryngoscopy (DL) and Bougie
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Aswan University
Epistaxis Nosebleed
Tranexamic Acid Versus Blood Stopper Treatments in Epistaxis Management
In this randonmized controlled trial, aim to compare the effectiveness of local administration of tranexamic acid and blood stopper (Ankaferd®) on cessation of bleeding in epistaxis patients.
- Trial name
- NCT06490653
- Testing
- Blood Stopper (Ankaferd)
- Volunteers
- 186 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Hereditary Hemorrhagic Telangiectasia (HHT)
A Trial of TER-1754 in Patients With Hereditary Hemorrhagic Telangiectasia
This is a Phase 1a/1b, multicenter study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and clinical activity of TER-1754 (a novel AKT1 inhibitor) in patients with HHT.
- Trial name
- NCT07255846
- Testing
- TER-1754
- Where
- United States
- Sponsor
- Terremoto Biosciences Inc.
Sinusitis
Hot Saline Irrigation Study
Many methods have been used to reduce bleeding during sinus surgery (FESS) in order to allow for the best surgical view and to reduce risk while in surgery.
- Trial name
- HSI (NCT01717274)
- Testing
- Hot saline irrigation
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Paul's Hospital, Canada
Epistaxis
Risk Factors of Epistaxis Recurrence in Adults
We study all patients admitted to the Emergency Department in the Institution between 01/2022 and 07/2023. The information about the recurrence of nose bleeding was searched on their medical file and by calling the patient to…
- Trial name
- FREA (NCT06657053)
- Where
- France
- Volunteers
- 145 people
- Sponsor
- University Hospital, Grenoble
Epistaxis
Assessment of Performance and Safety of an Asymmetric Balloon in the Treatment of Intranasal Bleeding Managed in an Emergency Setting
Between 10 and 12% of the general population suffers from epistaxis, out of which 10% would need to be medically managed. Most of patients treated for epistaxis are managed through emergency departments.
- Trial name
- BATSI (NCT03912051)
- Testing
- asymmetric balloon
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Dianosic
Dry Nose, Nose Irritation
Pilot Study to Assess Performance and Safety of SULFEX 13081.22 Nasal Spray in Patients With Dry or Irritated Nose
As the medical device is CE marked, the objective of this study is to provide performance and safety data on SULFEX 13081.22 nasal spray as close as possible to the routine care.
- Trial name
- NCT05499078
- Testing
- SULFEX 13081.22
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Church & Dwight Company, Inc.
Epistaxis Nosebleed
Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid
Nosebleeds are very common, occurring in 60% of the population; in some patients, nosebleeds are a life-threatening emergency. To stop a nosebleed in the emergency department, doctors usually have to burn the nose (called…
- Trial name
- Bloody SIMPLE (NCT06997796)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Dr. Anne Conlin
Hereditary Hemorrhagic Telangiectasia, Rendu Osler Disease
Prospective Study of Antiplatelet and Anticoagulation Therapy in Hereditary Haemorrhagic Telangiectasia
The goal of this clinical trial is to evaluate in real life, in patients with Hereditary Hemorrhagic Telangiectasia (HHT), the tolerance of the strategy of use of anticoagulant and/or antiplatelet, by comparing a new exposure…
- Trial name
- PROPLACO-Tel (NCT05641142)
- Testing
- monitoring the use of anticoagulant and/or antiplatelet therapy in patients with osler rendering disease
- Where
- 18 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis
Prospective Pilot Study of Floseal for the Treatment of Anterior Epistaxis in Patients With (HHT)
Current management strategies for severe and recurrent epistaxis secondary to Hereditary hemorrhagic telangiectasia (HHT) include surgical procedures, and uncomfortable nasal packing, both of which are often only short-term…
- Trial name
- NCT02638012
- Testing
- Floseal, Packing
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Epistaxis
Hot Water Irrigation in Posterior Epistaxis
This study was aimed to assess the efficacy and factors affecting the success of hot water irrigation in management of posterior epistaxis.
- Trial name
- NCT04151888
- Testing
- Foley catheter
- Volunteers
- 20 people
- Sponsor
- Assiut University
Epistaxis
Topical Intranasal Tranexamic Acid for Epistaxis in the Emergency Department
It is estimated that epistaxis results in 4.5 million emergency department visits per year throughout the United States. Due to the adverse effects of standard treatment options for epistaxis, tranexamic acid (TXA) may be…
- Trial name
- NCT02930941
- Testing
- Tranexamic Acid, 0.9% Sodium Chloride
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Davis
Epistaxis, Atherosclerosis
Carotid Intima Media Thickness (CIMT) in Epistaxis
Epistaxis is a very frequent emergency among adults and often needs specialised treatment in an ENT-department. Among others, atherosclerosis is often named as a reason for an increased risk for Epistaxis.
- Trial name
- NCT03092973
- Testing
- Ultrasound
- Where
- Switzerland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Telangiectasia, Hereditary Hemorrhagic
Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose
Epistaxis are present in over 90 % of patients with Rendu - Osler . They involve no significant difference 2 sexes. They often appear in childhood and adolescence and are present in three-quarters of patients at the age of 20…
- Trial name
- EROSB (NCT02157987)
- Testing
- bevacuzimab spray
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Nasal Obstruction, Rhinitis, Vasomotor
Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer
The purpose of this study is to learn whether nasal saline irrigation is beneficial to patients undergoing radiation therapy for oropharyngeal cancer.
- Conditions
- Nasal Obstruction, Rhinitis, Vasomotor, Epistaxis
- Trial name
- NCT02338102
- Testing
- Saline mixture
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Lisa Shnayder
Oral Surgery
Epinephrine Nasal Drops for Epistaxis During Nasal Intubation
Epistaxis is the most common complication of nasotracheal intubation. Incidence of epistaxis during nasotracheal intubation ranges from 22% to 80%.
- Trial name
- NCT06789549
- Testing
- epinephrine nasal drops, oxymetazoline nasal drops
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Padjadjaran