Clinical trials: Nose Bleed
Shellfish Hypersensitivity, Epistaxis
NOVAPAK Nasal Packing in Shellfish Allergic Patients
NOVAPAK is a sponge-like material made from materials found in shellfish. It is commonly used after nasal surgery or in nasal bleeding, as it promotes healing, decreases bleeding, and has antibacterial properties.
- Trial name
- NCT05343650
- Testing
- NOVAPAK nasal packing applied to forearm, NOVAPAK nasal packing applied to nasal cavity
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Telangiectasia, Hereditary Hemorrhagic, Rendu Osler Disease
Efficacy of Nintedanib Per os as a Treatment for Epistaxis in HHT Disease.
The recognized manifestations of HHT are all due to abnormalities in vascular structure. Epistaxis are spontaneous, very variable, may occur as often as several times every day, and are recurrent in 90% of patients and associated…
- Trial name
- EPICURE (NCT03954782)
- Testing
- Nintedanib 150 mg and 100 mg soft capsules
- Where
- 8 sites in France
- Volunteers
- 61 people
- Sponsor
- Hospices Civils de Lyon
Nasal Bleeding, Nasotracheal Intubation
Adrenaline Nasal Pack vs Xylometazoline Nasal Drops During Nasotracheal Intubation
The goal of this trial is to compare efficacy of xylometazoline nasal drops and adrenaline nasal pack in participants undergoing elective oromaxillofacial surgeries.
- Trial name
- NCT06801522
- Testing
- 0.1% xylometazoline nasal drops, Adrenaline nasal pack
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Epistaxis
Control of Epistaxis With Surgiflo
This is a blind trial to test if Surgiflo is effective in posterior epistaxis. After the investigators see than anterior tamponade is not effective stopping epistaxis, the investigators try using Surgiflo and if it does not work…
- Trial name
- NCT01051427
- Testing
- Surgiflo, Nasal catheter
- Where
- Spain
- Volunteers
- 3 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Chronic Rhinosinusitis (Diagnosis)
Adrenaline Solution Irrigation and Bleeding During Sinus Surgery
Intranasal irrigation with normal saline is routinely used in sinus surgery to clean the tip of the nasal endoscope and clear the surgical field from blood.
- Trial name
- NCT04551703
- Testing
- Adrenaline saline irrigation
- Volunteers
- 60 people
- Sponsor
- Jordan University of Science and Technology
Chronic Sinusitis, Nasal Polyposis
FESS With or Without Intranasal Desmopressin in Chronic Rhinosinusitis With Nasal Polyps
Chronic rhinosinusitis with nasal polyps is a condition that causes long-lasting inflammation and swelling in the nose and sinuses and may lead to nasal blockage, nasal discharge, facial pressure, and reduced sense of smell.
- Trial name
- NCT07855315
- Testing
- Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray, Functional Endoscopic Sinus Surgery
- Volunteers
- 174 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Epistaxis
NOrth American Study for the Treatment of Recurrent epIstaxis With DoxycycLine: The NOSTRIL Trial
The purpose of this research study is to determine whether Doxycycline can be used to control nosebleeds (epistaxis) for patients with Hereditary Hemorrhagic Telangiectasia (HHT).
- Trial name
- NOSTRIL (NCT04167085)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, Los Angeles
Pain, Postoperative Pain
A Comparison Between Conventional Throat Packs and Pharyngeal Placement of Tampons in Rhinology Surgeries
Post-operative, throat pain, nausea and vomiting is a common occurrence in rhinology surgeries due to the use of throat packs during the procedure.
- Conditions
- Pain, Postoperative Pain, Bleeding, Nose Bleed
- Trial name
- NCT03678168
- Testing
- Throat Pack, Pharyngeal Tampons
- Where
- Bahrain
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- King Hamad University Hospital, Bahrain
Hereditary Haemorrhagic Telangiectasia (HHT)
Diet and Hereditary Haemorrhagic Telangiectasia
Hereditary Haemorrhagic Telangiectasia (HHT) affects 1 in 5,000 people. The purpose of this study is to provide data regarding the diet and nosebleed frequency using a questionnaire. This will be filled in by people with HHT.
- Trial name
- NCT01692015
- Testing
- Questionnaire on dietary history, Questionnaire on nosebleed severity, One week food diary generated by weighing foods
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Hereditary Hemorrhagic Telangiectasia, Epistaxis
Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)
Hereditary Hemorrhagic Telangiectasia (HHT) is a rare (~ 1/6000) but ubiquitous genetic disease. It is associated with abnormal angiogenesis and autosomal dominant inheritance, leading to telangiectasias and arteriovenous…
- Trial name
- ALEGORI (NCT02106520)
- Testing
- Bevacizumab
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Epistaxis
Xylometazoline and Cocaine for Nasal Vasoconstriction
The objective of this study is to compare xylometazoline and cocaine's effect on minimizing epistaxis when administered as a local vasoconstrictor prior to nasal intubation.
- Trial name
- NCT05334017
- Testing
- Xylometazoline 0,1%, Cocaine 4%
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Nasal Bleeding
Determining the Effects of Foley Catheter-assisted Nasal Intubation on Nasal Bleeding in Adult Patients
Nasal endotracheal intubation is a well-utilized and important endotracheal intubation route to allow good surgical access for operations involving the oral cavity.
- Trial name
- NCT05072392
- Testing
- Foley catheter
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Mount Sinai Hospital, Canada
Trauma-related Wound, Head Injury
Teaching First Aid and Trauma Management to School Students
This proposal aims to describe research that will utilize first aid in primary education students and will attempt to identify the frequency with which the training should be repeated and the type of trainer who will carry out…
- Conditions
- Trauma-related Wound, Head Injury, Choking, Nose Bleed
- Trial name
- NCT05563129
- Testing
- First aid lessons
- Where
- Greece
- Volunteers
- 192 people
- Sponsor
- University of Ioannina
Hereditary Hemorrhagic Telangiectasia
Anti-Estrogen Therapy for Hereditary Hemorrhagic Telangiectasia A Double-Blind Placebo-Controlled Clinical Trial
Hereditary hemorrhagic telangiectasia (HHT) is associated with recurrent epistaxis in 90% of cases. Good response to hormone treatment has been documented, although its use remains controversial.
- Trial name
- NCT00375622
- Testing
- Tamoxifen
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Deviated Nasal Septum
Quilting Versus Chain Suture in Septoplasty
The goal of this clinical trial is to compare the effectiveness and postoperative outcomes of quilting suture and chain suture techniques in patients undergoing septoplasty for symptomatic deviated nasal septum.
- Trial name
- NCT07860502
- Testing
- Quilting Suture Technique, Chain Suture Technique
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Upper GI Bleeding
Inhalation of Sevoflurane Versus Intravenous Midazolam,Ketamine,Propofol For Pediatrics Undergoing Upper GI Endoscopy
In the field of pediatric gastroenterology, upper gastrointestinal endoscopy has established itself as a diagnostic and therapeutic tool. In order to increase patient tolerance during this procedure, deep sedation is essential.
- Trial name
- NCT05474937
- Testing
- Sevoflurane Inhalation Solution, Midazolam, Ketamine and Propofol
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Zagazig University
Postoperative Bleeding, Skin Cancer Face
Tranexamic Acid in Nasal Mohs Reconstruction
This study will be a prospective randomized control trial to evaluate the effects of subcutaneously administered TXA among patients undergoing nasal Mohs reconstruction with local flaps at VUMC.
- Trial name
- NCT06057675
- Testing
- Treatment (tranexamic acid and 1% lidocaine with 1:100,000 epinephrine), Control (1% lidocaine with 1:100,000 epinephrine)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Epistaxis
Nasal Intubation Using a Parker Flex-tip Endotracheal Tube Compared to a Nasal RAE Tube
The purpose of this study is to determine the degree of epistaxis following nasal intubation with either a nasal endotracheal (RAE) tube with bevel facing left or Parker Flex-Tip endotracheal tube with bevel facing posteriorly…
- Trial name
- NCT02315677
- Testing
- Nasal Intubation with nasal RAE endotracheal tube, Nasal Intubation with Parker Flex-Tip endotracheal tube
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Atmospheric Pressure; Adverse Effect, Epistaxis Nosebleed
Atmospheric Pressure and Epistaxis Relationship
In this study, investigators aim to understand the relationship between changes in atmospheric pressure and blood pressure, and to investigate whether these changes have an impact on the etiology of epistaxis.
- Trial name
- NCT06531577
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Saglik Bilimleri Universitesi
Cardiovascular Disease, Epistaxis
Correlation Between Epistaxis and Cardiovascular Disease
Investigators examine blood-pressure variance, several cardiovascular risk factors of patient with epistaxis. As a result of collected data, investigators look into correlation between epistaxis and hypertensive cardiovascular…
- Trial name
- CBECD (NCT02677467)
- Testing
- Blood-pressure variability
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hanyang University