Clinical trials: Nose Deformity
Septal Deformity, Nasal Obstruction
A Clinical Study to Evaluate the Safety and Efficacy of Surgical Material for Nasal Septoplasty
The purpose of this clinical trial is to evaluate safety and efficacy of TnR mesh for patients who need nasal septoplasty for septal deformity with nasal obstruction.
- Trial name
- NCT03088618
- Testing
- Nasal septoplasty
- Where
- 2 sites in South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- T&R Biofab Co., Ltd.
Cystic Fibrosis
Primary Nasal Cell Culture as a Tool for Personalized Therapy in Cystic Fibrosis
characterization of CFTR function and expression in nasal primary cells collected from patients with cystic fibrosis in comparison to their parents, healthy heterozygotes and healthy controls
- Trial name
- Epiithelix (NCT03652090)
- Testing
- cell sampling
- Volunteers
- 112 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies
This phase II trial studies the side effects and the best dose of alemtuzumab when given together with fludarabine phosphate and low-dose total body irradiation (TBI) and how well it works before donor stem cell transplant in…
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Trial name
- NCT00040846
- Testing
- alemtuzumab, fludarabine phosphate, total-body irradiation
- Where
- 7 sites in United States, Italy
- Volunteers
- 60 people
- Sponsor
- Fred Hutchinson Cancer Center
Respiratory Distress Syndrome, Intubation; Difficult or Failed
Nasal Intermittent Positive Pressure Ventilation During Neonatal Intubation
The study aims to determine whether the use of nasal intermittent positive pressure ventilation (NIPPV) during neonatal endotracheal intubation increases the rate of successful intubation without physiological instability during…
- Conditions
- Respiratory Distress Syndrome, Intubation; Difficult or Failed, Newborn Morbidity, Desaturation of Blood
- Trial name
- NCT06549283
- Testing
- Nasal intermittent positive pressure ventilation (NIPPV) via binasal cannula during neonatal intubation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Muğla Sıtkı Koçman University
Ear Deformities, Acquired, Ear; Deformity, Congenital
Evaluation of the Auryzon Devices in the Optimization of Ear and Nose Reconstruction Procedures
This study evaluates the efficacy of the AuryzoN devices in the ear and nose reconstruction surgeries, both in terms of operative time and overall quality of reconstruction.
- Conditions
- Ear Deformities, Acquired, Ear; Deformity, Congenital, Microtia, Nose Deformity
- Trial name
- NCT03624608
- Testing
- AuryzoN Family of Devices
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Reconstrata, LLC
Cleft Palate
Repair of Oronasal Fistula Using Interpositional Buccal Pad of Fat as a Free Graft in a Cleft Palate Patient
36 cleft palate patients had residual oronasal fistula included in this study divided randomly to two groups group I (control group): the fistula was repaired using two layers (oral and nasal layers) group II (study group): The…
- Trial name
- NCT06807450
- Testing
- closure of oro-nasal fistula in cleft palate patients
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tanta University
Hereditary Hemorrhagic Telangiectasia
Timolol Gel for Epistaxis in Hereditary Hemorrhagic Telangiectasia
This study is a double-blinded, randomized controlled trial to evaluate the efficacy of an intranasal topical timolol gel in the care for epistaxis in adults with hereditary hemorrhagic telangiectasia.
- Trial name
- ETIC-HHT (NCT04139018)
- Testing
- Timolol Gel
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Re-treatment of Cleft Lip and Nasal Deformation
Clinical Evaluation of Re-treatment of Cleft Lip and Nasal Deformation in Patients With Post Repair Deformities
Clinical Evaluation of Re-treatment of Cleft Lip and Nasal Deformation in Patients With Post Repair Deformities. A Randomized Controlled Study
- Trial name
- NCT07348185
- Testing
- Procedure / Surgery
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Kidney Cancer, Leukemia
Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors
RATIONALE: Glutamine may help lessen neuropathy caused by chemotherapy. It is not yet known whether glutamine is more effective than a placebo in treating neuropathy caused by vincristine.
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Neurotoxicity
- Trial name
- NCT00365768
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Columbia University
Hypotonia, Muscle, Obstructive Sleep Apnea
Long-term Evaluation of Nasopharyngeal Airway in Hypotonia
This research is studying the long term use of a nasal airway device (self-supporting nasopharyngeal airway; "ssNPA") in children with hypotonic upper airway obstruction to learn about its effectiveness and tolerability as a…
- Conditions
- Hypotonia, Muscle, Obstructive Sleep Apnea, Nasal Airway Obstruction
- Trial name
- NCT06614582
- Testing
- Self-Supporting Nasopharyngeal Airway (ssNPA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Transient Tachypnea of the Newborn
nHFOV Versus nCPAP in Transient Tachypnea of the Newborn
In this prospective, randomised clinical trial the investigators aim to assess if nasal high frequency oscillatory ventilation (nHFOV) could be used as the primary modality of respiratory support in late preterm and term infants…
- Trial name
- NCT03006354
- Testing
- nHFOV, nCPAP
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Pierre Robin Syndrome
Effect of Oral Enteral Nutrition in Pierre Robin Syndrome
This was a randomized controlled study. The infants enrolled were randomly divided into the IOE group (with Intermittent Oro-Esophageal Tube Feeding, n=25) and the PNG group (with Nasogastric Tube Feeding, n=23), all receiving…
- Trial name
- NCT06303973
- Testing
- IOE, PNG
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Muhammad
Nose; Anomaly
Objective Assessment for Cleft Lip Nasal Deformity Correction
Rhinoplasty remains one of the most challenging procedures in plastic surgery, and patients with cleft lip nasal deformity pose an even greater challenge, in which biggest issue is to achieve caudal nose harmony and creation of…
- Trial name
- NCT03683199
- Testing
- Rhinoplasty
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Assiut University
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Atopic Dermatitis, Food Allergy in Children
Preventing Atopic Dermatitis and ALLergies in Children
The primary objective is of the PreventADALL study is to test if primary prevention of allergic diseases is possible by simple and low cost strategies, and secondary to asses the impact of xenobiotic exposure and microbiota in…
- Conditions
- Atopic Dermatitis, Food Allergy in Children, Asthma, Rhinitis, Allergic
- Trial name
- PreventADALL (NCT02449850)
- Testing
- Food intervention, Skin care
- Where
- Norway
- Volunteers
- 2,701 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Choanal Atresia
A Comparative Study of Endoscopic Choanal Canalization and Mitomycin C Application vs Endoscopic Crossover Flap Technique
determine the optimal surgical strategy for achieving 1. long-term outcomes 2. minimizing complications 3. improving outcomes in CCA patients
- Trial name
- NCT07173023
- Testing
- Transnasal Puncture with Mitomycin C application, Endoscopic Crossover Flap Repair
- Volunteers
- 30 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome (&Amp; [Hyaline Membrane Disease])
Early Surfactant Administration at FiO₂ >0.25 Under NIPPV for RDS in Very Preterm Infants
This multicenter randomized controlled trial investigates whether initiating pulmonary surfactant (PS) at a lower oxygen threshold (FiO₂ >0.25) during nasal intermittent positive pressure ventilation (NIPPV) for very preterm…
- Trial name
- NCT07100652
- Testing
- Threshold FiO₂
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Jiulongpo No.1 People's Hospital
Respiratory Distress Syndrome, Newborn, Premature
Predictors for Nasal Intermittent Positive Pressure Ventilation Failure for Premature Infants With Respiratory Distress Syndrome
Non-invasive respiratory support methods have been widely used in premature babies with respiratory distress syndrome (RDS) which has changed the basic management of premature babies in the early period.
- Trial name
- NCT05260424
- Testing
- non-invasive ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 397 people
- Sponsor
- Ankara City Hospital Bilkent
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer
RATIONALE: Giving an infusion of natural killer cells from a donor after a donor stem cell transplant may help kill any remaining cancer cells after the transplant.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00823524
- Testing
- donor natural killer cell infusion
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Asan Medical Center
Rhinitis, Allergic, Asthma
Study on the Correlation Between Intestinal Microecology and Allergic Diseases in Children
Allergic diseases, including allergic reactions of respiratory tract and skin, are often triggered by mast cell degranulation mediated by allergen-specific IgE and chronic inflammation of target organs, which are involved in a…
- Conditions
- Rhinitis, Allergic, Asthma, Dermatitis, Atopic, Urticaria
- Trial name
- NCT04938700
- Testing
- probiotics, conventional medical treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine