Clinical trials: Nosebleeds
Hereditary Hemorrhagic Telangiectasia (HHT)
A Trial of TER-1754 in Patients With Hereditary Hemorrhagic Telangiectasia
This is a Phase 1a/1b, multicenter study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and clinical activity of TER-1754 (a novel AKT1 inhibitor) in patients with HHT.
- Trial name
- NCT07255846
- Testing
- TER-1754
- Where
- United States
- Sponsor
- Terremoto Biosciences Inc.
Telangiectasia, Hereditary Hemorrhagic
Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose
Epistaxis are present in over 90 % of patients with Rendu - Osler . They involve no significant difference 2 sexes. They often appear in childhood and adolescence and are present in three-quarters of patients at the age of 20…
- Trial name
- EROSB (NCT02157987)
- Testing
- bevacuzimab spray
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Epistaxis
Microporous Polysaccharide Hemospheres Epistaxis
The purpose of this study is to compare a new treatment for nosebleeds to the treatment that has been used for many years.
- Trial name
- NCT02466464
- Testing
- Microporous Polysaccharide Hemospheres, Nasal Tampon
- Where
- United States
- Sponsor
- Emory University
Epistaxis Nosebleed
Tranexamic Acid Versus Blood Stopper Treatments in Epistaxis Management
In this randonmized controlled trial, aim to compare the effectiveness of local administration of tranexamic acid and blood stopper (Ankaferd®) on cessation of bleeding in epistaxis patients.
- Trial name
- NCT06490653
- Testing
- Blood Stopper (Ankaferd)
- Volunteers
- 186 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Epistaxis
Topical Intranasal Tranexamic Acid for Epistaxis in the Emergency Department
It is estimated that epistaxis results in 4.5 million emergency department visits per year throughout the United States. Due to the adverse effects of standard treatment options for epistaxis, tranexamic acid (TXA) may be…
- Trial name
- NCT02930941
- Testing
- Tranexamic Acid, 0.9% Sodium Chloride
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Davis
Tranexamic Acid, Epistaxis
Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis
Aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and Merocel packing.
- Conditions
- Tranexamic Acid, Epistaxis, Nasal Packing
- Trial name
- NCT03360045
- Testing
- Tranexamic Acid, Normal saline, Merocel
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Kecioren Education and Training Hospital
Epistaxis, ENT Disorder
Correlation Between PT and INR to Factor 7
The purpose of our study: Given the large number of coagulability tests done before a number of surgeries, specially otolaryngology procedures, such as tonsillectomy and adenoidectomy, as well as a part of epistaxis workup…
- Trial name
- NCT03788460
- Testing
- no intervention
- Volunteers
- 60 people
- Sponsor
- Laniado Hospital
Epistaxis
Floseal Treatment for Posterior Epistaxis Study
Effectiveness of Floseal for the treatment of posterior epistaxis.
- Trial name
- NCT01098578
- Testing
- Floseal
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Oral Surgery
Epinephrine Nasal Drops for Epistaxis During Nasal Intubation
Epistaxis is the most common complication of nasotracheal intubation. Incidence of epistaxis during nasotracheal intubation ranges from 22% to 80%.
- Trial name
- NCT06789549
- Testing
- epinephrine nasal drops, oxymetazoline nasal drops
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Padjadjaran
Nasotracheal Intubation, Nasal Bleeding
Nasotracheal Intubation Over a Bougie
The purpose of this study is to determine whether nasal intubation over a bougie placed via a nasal trumpet will decrease nasal trauma when compared to the conventional technique of blind nasal endotracheal tube passage.
- Trial name
- NCT03003455
- Testing
- Nasotracheal intubation over a bougie, Conventional Nasotracheal Intubation
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Epistaxis
Management of Persistent Epistaxis Using Floseal Hemostatic Matrix
Nosebleeds that persist even after adequate traditional nasal packing may require aggressive treatment strategies to stop bleeding.
- Trial name
- NCT02488135
- Testing
- Floseal Hemostatic Matrix, Traditional Nasal Packing
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Alberta
Epistaxis, Intubation Complication
The Effect of Bevel Direction on the Pathway of the Nasotracheal Tube
In this study, the subjects are divided into two groups (group I: intervention group = the nasotracheal tube inserted with the bevel of the nasal tube facing the direction of the patient's head, and Group II: conventional group =…
- Trial name
- NCT03740620
- Testing
- Bevel facing the cephalad direction of the patient, Bevel facing leftward of the patient
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hereditary Hemorrhagic Telangiectasia, Rendu Osler Disease
Prospective Study of Antiplatelet and Anticoagulation Therapy in Hereditary Haemorrhagic Telangiectasia
The goal of this clinical trial is to evaluate in real life, in patients with Hereditary Hemorrhagic Telangiectasia (HHT), the tolerance of the strategy of use of anticoagulant and/or antiplatelet, by comparing a new exposure…
- Trial name
- PROPLACO-Tel (NCT05641142)
- Testing
- monitoring the use of anticoagulant and/or antiplatelet therapy in patients with osler rendering disease
- Where
- 18 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hereditary Haemorrhagic Telangiectasia (HHT)
Diet and Hereditary Haemorrhagic Telangiectasia
Hereditary Haemorrhagic Telangiectasia (HHT) affects 1 in 5,000 people. The purpose of this study is to provide data regarding the diet and nosebleed frequency using a questionnaire. This will be filled in by people with HHT.
- Trial name
- NCT01692015
- Testing
- Questionnaire on dietary history, Questionnaire on nosebleed severity, One week food diary generated by weighing foods
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Hereditary Hemorrhagic Telangiectasia, Epistaxis
Efficacy of Thalidomide in the Treatment of Hereditary Hemorrhagic Telangiectasia
Hereditary hemorrhagic telangiectasia (HHT) (OMIM 187300 and 600376), also known as Rendu-Osler-Weber syndrome, is an autosomal dominant disease and has a prevalence between 1:5000 and 1:8000 in different populations.
- Trial name
- THALI-HHT (NCT01485224)
- Testing
- Thalidomide
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Hereditary Hemorrhagic Telangiectasia, Epistaxis
Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)
Hereditary Hemorrhagic Telangiectasia (HHT) is a rare (~ 1/6000) but ubiquitous genetic disease. It is associated with abnormal angiogenesis and autosomal dominant inheritance, leading to telangiectasias and arteriovenous…
- Trial name
- ALEGORI (NCT02106520)
- Testing
- Bevacizumab
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Deviated Nasal Septum, Postoperative Nasal Pain
Comparative Study - Transseptal Suture Technique Verses Anterior Nasal Packing After Septoplasty
The goal of this clinical trial is to see the outcomes of the two techniques used after septoplasty in terms of postoperative nasal pain and nasal bleeding in the patients with deviated nasal septum of 18 to 50 years of age…
- Conditions
- Deviated Nasal Septum, Postoperative Nasal Pain, Postoperative Nasal Bleeding
- Trial name
- NCT07745127
- Testing
- Trans-septal suture technique, Anterior nasal packing
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Ghazal Iftakhar
Supraglottic Airway Obstruction, Airway Complication of Anesthesia
Wei Nasal Jet Tube vs Nasal Cannula Oxygen Support in Gastrointestinal Endoscopy Patients
Sedoanalgesia is applied to patients during gastrointestinal endoscopy. Sedoanalgesia may cause respiratory depression and hypoxia in patients.
- Conditions
- Supraglottic Airway Obstruction, Airway Complication of Anesthesia, Airway Obstruction, Anesthesia Complication
- Trial name
- NCT05783050
- Testing
- Wei Nasal Jet Tube, Nasal Cannula Oxygen Support
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Von Willebrand Disease (VWD)
Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease
WILL MANAGE is a prospective multicenter controlled open label randomized trial comparing an algorithm-based multidisciplinary management to a standard of care to reduce the incidence of bleeding (GI bleeding or severe epistaxis)…
- Trial name
- WILL MANAGE (NCT06651255)
- Testing
- Optimized management, Standard of care management
- Where
- 17 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Lille
Epistaxis
Outcome of Hyaluronic Acid Gel Versus Petroleum Jelly in Treatment of Epistaxis
The aim of this study is to compare the efficacy of Hyaluronic Acid Gel with Petroleum Jelly in treatment of epistaxis.
- Trial name
- NCT07531472
- Testing
- Hyaluronic Acid Gel, Petroleum jelly
- Volunteers
- 50 people
- Sponsor
- Assiut University