Clinical trials: Nosocomial Infections
Covid19, Ventilator Associated Pneumonia
Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia:
A Respiratory infection with the SARS-CoV2 virus is associated with a major risk of viral pneumonia that can lead to respiratory distress requiring resuscitation.
- Conditions
- Covid19, Ventilator Associated Pneumonia, Nosocomial Pneumonia
- Trial name
- COVAP (NCT04488510)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Infection
Reduction of Nosocomial Vancomycin -Resistant Enterococci (VRE) Colonization and Infection by Active Surveillance and Intervention of Infection Control
Vancomycin -resistant enterococci(VRE) has emerged as one of the most common nosocomial pathogen of health-care associated infection since 1988.
- Trial name
- NCT01201031
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University WanFang Hospital
Nosocomial Infections
ED Residents MBP During CVC Placement: Sim Lab Based Training
1. Baseline performance in maximal barrier precaution technique of Emergency Medicine (EM) residents, certified in CVC placement, is poor 2.
- Trial name
- EM CVC MBP (NCT00791583)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care
SEPREVEN: a Stepped-wedge Randomised Controlled Trial
Adverse events are frequent in Neonatal Intensive Care Units' (NICU) patients and account for a high morbidity and mortality. Possible severe adverse events are central line associated bloodstream infections (CLABSI), ventilator…
- Conditions
- Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care, Catheter-related Bloodstream Infection (CRBSI) Nos, Quality of Healthcare
- Trial name
- SEPREVEN (NCT02598609)
- Testing
- Education program for NICU caregivers
- Where
- 12 sites in France
- Volunteers
- 8,000 people
- Sponsor
- Dr Caeymaex Laurence
Nosocomial Infection, Sepsis
Application of an Antimicrobial Stewardship Program in Brazilian ICUs Using Machine Learning Techniques and an Educational Model
Antimicrobial agents are frequently used empirically and include therapy for both Gram-positive and Gram-negative bacteria. In Brazil, multidrug-resistant Gram-negative pathogens are the cause of most nosocomial infections in…
- Trial name
- NCT05312034
- Testing
- Implementation of the predictive model for an antimicrobial management program
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Gram Negative Pneumonia, Gram-Negative Bacterial Infections
Clinical Trial to Study the Efficacy and Safety of Fluorothiazinone (N.F. Gamaleya NRCEM) in Prophylaxis of Nosocomial Bacterial Infections With Participation of Patients on MV
This study is designed to evaluate the clinical and antibacterial efficacy, safety and pharmacokinetics of the drug Fluorothiazinone compared to placebo to prevent nosocomial gram-negative bacterial infections with participation…
- Conditions
- Gram Negative Pneumonia, Gram-Negative Bacterial Infections, Bacteremia Caused by Gram-Negative Bacteria
- Trial name
- NCT06135350
- Testing
- Fluorothiazinone, tablets 300 mg at a dose of 2400 mg/day
- Where
- 2 sites in Russia
- Volunteers
- 234 people
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Pneumonia
Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002)
This is a 1:1 ratio, randomized, double-blind, double-dummy, multicenter, global Phase 3 study of tedizolid phosphate (TR-701 FA) 200 mg intravenous (IV) once daily for 7 days versus linezolid (Zyvox®, Zyvoxid®, etc) 600 mg IV…
- Trial name
- NCT02019420
- Testing
- Tedizolid phosphate, Linezolid
- Volunteers
- 726 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Contaminated Medical or Biological Substances, Environmental-Pollution-Related Condition
Potential Risk for Bacterial Contamination in Ventilator Systems
Background: Few studies have investigated the difference of bacterial contamination between conventional reused ventilator systems and disposable closed ventilator-suction systems.
- Trial name
- NCT03359148
- Testing
- Disposable ventilator system, Conventional reused ventilator system
- Volunteers
- 27 people
- Sponsor
- Chang Gung University
Dysbiosis, Catheter-Related Infections
Cutaneous Microbiota Evolution in ICU Patients With CVC (ICMc)
Intensive Care Unit (ICU) patients are exposed to catheter-related infections with an important morbidity. Catheter colonization is constant but infection is not. Cutaneous dysbiosis could be the missing link.
- Trial name
- ICMc (NCT06095076)
- Testing
- Skin swabbing, Data collection
- Where
- French Guiana
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Nosocomial Infections, Sepsis
Safety and Efficacy of Veronate® Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants
The purpose of this study is to show whether Veronate, a donor-selected staphylococcal human immune globulin intravenous (IGIV), can prevent an infection in the blood caused by staphylococcal bacteria in premature babies weighing…
- Conditions
- Nosocomial Infections, Sepsis, Staphylococcal Infections, Candidemia
- Trial name
- NCT00113191
- Testing
- Veronate
- Where
- 93 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Bristol-Myers Squibb
Ventilator Associated Pneumonia
Perpetual Observational Study - Ventilator Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation.
- Trial name
- POS-VAP (NCT05719259)
- Where
- 35 sites in Albania, Belgium and 11 more
- Volunteers
- 20,000 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Health Care Associated Infection
Health Care Associated Infection Surveillance in NICU
Healthcare - Associated Infection Surveillance In Neonatal Intensive Care Unit of Assiut University Children's Hospital.The objective of study is to determine the incidence, infection sites, causative organisms and risk factors…
- Trial name
- NCT03254316
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Gehad Salah El-Den Mahmoud Mohammad
Nosocomial Infections, MRSA Colonization
Comparison of Two Protocols to Prevent the Acquisition of Methicillin-Resistant Staphylococcus Aureus.
Nosocomial infections is a major problem in intensive care units due to both growing incidence and pathogens implicated which become increasingly resistant to antibiotics.
- Trial name
- NCT00151606
- Testing
- Reinforced isolation + Muciprocine
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- Rennes University Hospital
Multidrug-resistant Colonization
Studies of the Human Microbiome in Clinical Center Patients
Background: The intestines, mouth, and skin all contain billions of bacteria and some fungi. Every person s body contains microorganisms like these. They normally do not make people sick.
- Trial name
- NCT01933620
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
COVID-19, Molecular Sequence Variation
COVID-19 Genomic Sequencing for Nosocomial Outbreak Investigations
This is a tertiary care hospital-based prospective molecular epidemiology study in Montreal, Canada. When nosocomial transmission was suspected by local infection control teams' investigations, SARS-CoV-2 viral genomic sequencing…
- Conditions
- COVID-19, Molecular Sequence Variation, Nosocomial Infection
- Trial name
- NOSO-COVID (NCT05411562)
- Testing
- SARS-CoV-2 genomic sequencing
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Enterobacteriaceae Infections, Hospital-Acquired Infection
Nosocomial Outbreak of BHRe in an Intensive Care Unit During SARS-CoV-2 Pandemic
Multidrug Resistant (MDR) bacteria have become a major worldwide public health challenge and hospitals are now increasingly faced with management of local outbreaks involving such pathogens.
- Trial name
- BHReICU (NCT05055479)
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Neutropenia in Prematures
Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF
Prevention trial of nosocomial infections in neutropenic prematures with G-CSF
- Trial name
- NCT00213759
- Testing
- filgrastim, dextrose 5%
- Where
- 9 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Hospital Acquired Infection
The Impact of Bedside Wipes in Multi-patient Rooms: a Prospective, Crossover Trial Evaluating Infections and Survival
Multidrug resistant organisms (MDRO) are prevalent in hospitals and are associated with hospital-acquired infections (HAI). High-touch surfaces serve as reservoirs and fomites for MDRO transmission.
- Trial name
- NCT05522725
- Testing
- Single-use wipes installed at the bedside
- Where
- Israel
- Volunteers
- 7,725 people
- Sponsor
- Assaf-Harofeh Medical Center
Respiratory Failure
Silver-Coated Endotracheal Tube to Reduce Ventilator Associated Pneumonia (VAP)
The purpose of this study is to determine if the use of a silver-coated endotracheal tube (ETT) can reduce the incidence and/or delay the time of onset of VAP when compared to a non silver-coated ETT in patients who have been…
- Trial name
- NASCENT (NCT00148642)
- Testing
- silver salts coated endotracheal tube, uncoated endotracheal tube
- Where
- 5 sites in United States
- Volunteers
- 2,003 people
- Sponsor
- C. R. Bard