Clinical trials: Numbness
Total Knee Arthroplasty
Insertion Distance of Femoral Perineural Catheters in the Context of Major Knee Surgery.
This study is designed to compare femoral perineural catheter insertion distances, in order to help determine which is the best for pain relief after knee surgery.
- Trial name
- NCT00726219
- Testing
- Femoral perineural catheter
- Where
- 2 sites in Canada
- Volunteers
- 72 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Anesthesia, Local, Anesthesia, Dental
Behavior of Children Related to Numbness After Dental Local Anesthesia
In children, behavior management is critical to the success of pediatric dental procedures. Most of the studies on local anesthesia performed in children deal with the question how to avoid or minimize pain during injection.
- Trial name
- NCT00363207
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Phythoterapy, Venipuncture Site Numbness
Antiseptic and Analgesic Action Acmella Oleracea Skin: Randomized Clinical Trial
Context: Research on natural products with therapeutic, analgesic or antimicrobial purpose should be encouraged to create new drugs.
- Conditions
- Phythoterapy, Venipuncture Site Numbness, Antimicrobial, Analgesic
- Trial name
- NCT02792972
- Testing
- A. oleracea, 70% alcohol
- Volunteers
- 60 people
- Sponsor
- Ana Beatriz Alkimim Teixeira Loyola
Post-Traumatic Stress Disorder
Carvedilol Versus Placebo for Treatment in Post Traumatic Stress Disorder (PTSD)
The investigators hypothesize that carvedilol, at less then therapeutic doses for cardiac effect, will reduce symptoms of Post Traumatic Stress Disorder.
- Trial name
- NCT01221792
- Testing
- Carvedilol
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Columbia Northwest Pharmaceuticals
Diabetic Peripheral Neuropathy (DPN)
Benfotiamine Versus Vitamin B1-6-12 for Diabetic Peripheral Neuropathy
The purpose of this clinical trial is to compare the efficacy of benfotiamine with vitamin B1-6-12 in reducing sensory neuropathy symptoms, numbness and pain in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07708233
- Testing
- Benfotiamine, Vitamin B1-6-12
- Where
- Thailand
- Volunteers
- 66 people
- Sponsor
- Thammasat University
Lateral Cutaneous Nerve of Thigh Lesion
Stroking Versus Ergon Technique in Pregnant Women
The study will focus on non-invasive management options for radiculopathy and functional activity in 3rd trimester women due to lateral cutaneous femoral nerve study.
- Trial name
- NCT05665413
- Testing
- TENS
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Anatomic Stage IV Breast Cancer AJCC v8, Chemotherapy-Induced Peripheral Neuropathy
Finding an Effective Dose of GM1 to Reduce or Prevent Neuropathy (Numbness or Weakness) Due to Treatment With Paclitaxel
This early phase/phase II trial tests the safety, side effects, and best dose of monosialotetrahexosylganglioside (GM1) and whether it works in reducing or preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Chemotherapy-Induced Peripheral Neuropathy, Metastatic Breast Carcinoma
- Trial name
- NCT05751668
- Testing
- Paclitaxel, Monosialotetrahexosylganglioside, Questionnaire Administration
- Where
- 33 sites in United States
- Volunteers
- 7 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cancer-related Problem/Condition, Neurotoxicity
Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer
RATIONALE: Electrical stimulation pain therapy may help relieve chronic pain and numbness caused by chemotherapy. PURPOSE: This pilot trial studies electrical stimulation pain therapy in treating chronic pain and numbness caused…
- Conditions
- Cancer-related Problem/Condition, Neurotoxicity, Pain, Peripheral Neuropathy
- Trial name
- NCT01196442
- Testing
- electrical stimulation pain therapy, questionnaire administration
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Virginia Commonwealth University
Inguinal Hernia
Elective Neurectomy During Inguinal Hernia Repair
Chronic inguinal neuralgia is one of the most important complications following inguinal hernia repair. It may even outweigh the benefit of the operation.
- Trial name
- NCT00492804
- Testing
- Lichtenstein hernia repair, Neurectomy
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Cantonal Hospital of St. Gallen
Trigeminal Neuralgia
Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia
Trigeminal neuralgia or tic douloureux is severe, often debilitating, facial pain that significantly impairs the patient's quality of life and health.
- Trial name
- NCT01364272
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Clavicle Fracture
Percutaneous Versus Open Plate Fixation of Diaphyseal Clavicle Fractures
This is a prospective, level II evidence comparison between two cohorts. This study is designed to compare the percutaneous versus open approach for plate fixation of diaphyseal clavicle fractures.
- Trial name
- NCT01405703
- Testing
- xrays
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Utah
Anesthesia, Dental
Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Mandibular Procedures
This Phase 3 study is designed as a multicenter, randomized, blinded, controlled study to evaluate the efficacy, pharmacodynamics, and safety of NV-101 administered as a submucosal injection following completion of a restorative…
- Trial name
- NCT00309361
- Testing
- Phentolamine Mesylate (NV-101)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Novalar Pharmaceuticals, Inc.
Vaginal Laceration During Delivery
The PAIN (Pelvic Area Injection for Numbness) Study
Postpartum pain can interfere with patient's ability to care for themselves, and their newborn, and untreated pain is associated with risk of greater opioid use, postpartum depression, and development of persistent pain.
- Trial name
- PAIN (NCT05972681)
- Testing
- Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Paresthesia and Hypoesthesia
Vitamin B Complex for Inferior Alveolar Nerve Paresthesia Recovery
Why is this study being done? Paresthesia is a change in sensation that can cause numbness, tingling, or loss of feeling in a part of the body.
- Trial name
- NCT07592897
- Testing
- Vitamin B Complex
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Penile Numbness
Vacuum Therapy for the Treatment of Penile Numbness/Sensory Changes
This is a prospective, uncontrolled, Hypothesis generating study. A total of eight adult male participants experiencing penile insensitivity will be recruited through the Ottawa Hospital's Men's Health Clinic.
- Trial name
- NCT07171567
- Testing
- Vacuum erection device
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Ottawa Hospital Research Institute
Parkinson Disease
Effects of Cervical Stabilization Exercises and Vibration Application in Individuals With Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease that causes a progressive decrease in motor functions, which is caused by the influence of dopaminergic pathways in the substantia nigra (SN).
- Trial name
- NCT05837715
- Testing
- Chattanooga Stabilizer pressure biofeedback, VibraSens - Focal Vibration Therapy (TechnoConcept - France), Telerehabilitation
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Soft Tissue Anesthesia (Numbness)
Safety and Efficacy Study of NV-101 in Dental Patients
The purpose of this study was: to determine if NV-101 accelerates recovery from numbness compared to placebo to evaluate safety of NV-101
- Trial name
- NCT00154167
- Testing
- NV-101 (phentolamine mesylate solution)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Novalar Pharmaceuticals, Inc.
Head Cancer, Neck Cancer
Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA)
Following preliminary studies carried out in our department on these subject and subjective findings during clinical examinations, it has been shown that pain is a symptom that is rarely reported following treatment.
- Conditions
- Head Cancer, Neck Cancer, Chronic Pain
- Trial name
- OCAPA (NCT04673981)
- Testing
- diagnostic tes for neuropathic pain
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chemotherapy-induced Peripheral Neuropathy
Feasibility Study for Electroacupuncture for Chemotherapy- Induced Peripheral Neuropathy (CIPN)
The purpose of the study is to determine the validity of a point-of-care nerve conduction device (NeuroMetrix) and Rydel-Seiffer tuning fork in assessing the level of peripheral neuropathy in patients with chemotherapy-induced…
- Trial name
- NCT04092764
- Testing
- Electroacupuncture, NeuroMetrix, Rydel-Seiffer tuning fork
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Ocular GVHD
The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients
The Investigators hypothesize that the recalcitrant nature of ocular GVHD may be related to corneal nerve damage and corneal hypoesthesia.
- Trial name
- NCT04700657
- Testing
- corneal sensation test
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University