Clinical trials: Nursing Homes
Advanced Dementia
Educational Video to Improve Nursing Home Care in End-stage Dementia
This is a 5-year cluster RCT of a video Advance Care Planning intervention vs. control among 360 nursing home residents with advanced dementia (N=180/arm) in 20 matched nursing homes (10 intervention/10 control).
- Trial name
- EVINCE (NCT01774799)
- Testing
- Advance care planning intervention, Control group
- Where
- United States
- Volunteers
- 804 people
- Sponsor
- Hebrew SeniorLife
Xerosis Cutis
Skin Health and Effectiveness of Standardized Skin Care Regimens in Nursing Home Residents
Residents of institutional long-term care facilities are at high risk for developing skin and tissue diseases, e.g. xerosis cutis (including pruritus), infections (e.g., tinea pedis, candidiasis), chronic wounds or neoplastic…
- Trial name
- NCT02216526
- Testing
- Cetaphil® Restoraderm, Excipial
- Where
- Germany
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- PD Dr. Jan Kottner
Osteoporosis, Postmenopausal, Osteoporosis
Preventing Osteoporosis Using Denosumab
The purpose of this research study is to find out if denosumab (Prolia®), an injection given in the arm under the skin every 6 months, works to treat bone loss and prevent it from worsening in older men and women (ages 65 and…
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis, Osteoporotic Fractures
- Trial name
- PROUD (NCT02753283)
- Testing
- denosumab, Calcium and Vitamin D
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Susan L. Greenspan
Deficiency of Vitamin D3
Optimizing Vitamin D in the Elderly
Vitamin D deficiency is highly prevalent in older people in the absence of vitamin D supplementation. The limited data available show marked inter-individual variability in response to vitamin D supplementation in very old, frail…
- Trial name
- NCT01554241
- Testing
- D3 2000 IU/day, D3 4000 IU/day, D3 50,000 IU weekly
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of California, San Francisco
Alzheimer Disease, Dementia
Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support
Nursing home (NH) patients with Alzheimer's disease and related dementias often receive unwanted, burdensome treatments such as hospitalization.
- Trial name
- APPROACHES (NCT03323502)
- Testing
- APPROACHES ACP Specialist Program, Standard of care
- Where
- 2 sites in United States
- Volunteers
- 47,396 people
- Sponsor
- Indiana University
Polypharmacy, Inappropriate Prescribing
Randomised, Controlled Trial of an Individual Deprescribing Intervention for Nursing Homes Residents
This study will evaluate the effects of a pharmacist-led, deprescribing-focused medication review on the use of inappropriate medications by nursing home residents
- Trial name
- OLD-NH-IDeI (NCT03655405)
- Testing
- Individual Deprescribing Intervention
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- Anne Niquille
Dementia, Staff Attitude
Speeko for Elderspeak: A Self-Monitoring App to Improve Nursing Home Communication
This study will test feasibility and preliminary effects of an automated and performance-based feedback app (Speeko for Elderspeak) that detects and reports the use of diminutives (terms of endearment such as honey, dearie, and…
- Trial name
- NCT04064164
- Testing
- Speeko for Elderspeak
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Depressive Symptoms, Quality of Life
Life Story Book With Mentally Alert Residents of Nursing Homes
The objective of this study is to study the effects of the Life Story Book intervention on depressive symptoms and meaning in life for mentally alert residents of nursing homes.
- Trial name
- NCT03851016
- Testing
- Life Story Book, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Houston
Palliative Care, Dementia
Implementation of a Telehealth Palliative Care Model for Persons With Dementia
Grounded in the Reach-Effectiveness-Adoption-Implementation-Maintenance (RE-AIM) Model, this study will assess the implementation outcomes of the Nurse Practitioner (NP) delivered telehealth Palliative Care Consultation in…
- Trial name
- IMPACT (NCT05001620)
- Testing
- Palliative Care Consultation
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Covid19, SARS-CoV Infection
COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing Homes
The purpose of this study is to test whether Fisetin, a senolytic drug, can assist in preventing an increase in the disease's progression and alleviate complications of coronavirus due to an excessive inflammatory reaction.
- Trial name
- COVID-FIS (NCT04537299)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Pressure Ulcer
Study of SANTYL® vs Hydrogel (SoloSite®) for Pressure Ulcers
This study is designed to compare SANTYL® versus hydrogel (SoloSite®) in the treatment of pressure ulcers for participants in a long-term care facility.
- Trial name
- NCT02718625
- Testing
- Santyl, SoloSite®
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Smith & Nephew, Inc.
Aging
Cycled Testosterone Therapy to Improve Physical Function in Frail Nursing Home Residents
Frailty is a recognized cause for disability, hospitalization, and mortality in nursing home residents. Testosterone treatment is among the potentially beneficial treatments in addition to resistance exercise for improving muscle…
- Trial name
- NCT02679274
- Testing
- Testosterone
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Dementia
Music & MEmory: A Pragmatic TRial for Nursing Home Residents With ALzheimer's Disease_part1
The purpose of this trial is to test the effects of a personalized music intervention (Music and Memory, Inc.) on agitated and aggressive behaviors for nursing home residents with dementia.
- Trial name
- METRIcAL (NCT03821844)
- Testing
- Music and Memory
- Where
- 4 sites in United States
- Volunteers
- 1,073 people
- Sponsor
- Brown University
Atrial Fibrillation, Deep Vein Thrombosis
Weekly Monitoring Strategy of Capillary INR Versus Monthly Monitoring Strategy of Venous INR in Elderly Patients in a Nursing Home.
This primary care study aims to compare the "time in therapeutic range" (TTR) of two strategies for monitoring the international normalized ratio (INR) over 6 months in nursing homes.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Stroke
- Trial name
- INR-CAP (NCT05561244)
- Testing
- Weekly monitoring using the capillary International Normalised Ratio strategy
- Where
- 33 sites in France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Respiratory Infection
Vitamin D Supplementation and Acute Respiratory Infection in Older Long-Term Care Residents
This study will test the role of high dose vitamin D supplementation in prevention of acute respiratory infection in older nursing home residents.
- Trial name
- NCT01102374
- Testing
- High Dose Vitamin D, Standard Dose Vitamin D, Usual Care
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Colorado, Denver
Alzheimer Disease, Dementia
Pragmatic Trial of Video Education in Nursing Homes
This is a pragmatic cluster-randomized control trial (RCT) of an Advance Care Planning (ACP) Video Program for nursing home (NH) patients ≥ 65 years old who are cared for in 360 NH facilities (intervention arm n=119; control arm…
- Conditions
- Alzheimer Disease, Dementia, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- PROVEN (NCT02612688)
- Testing
- ACP Video Program
- Where
- 2 sites in United States
- Volunteers
- 197,692 people
- Sponsor
- Brown University
COVID-19, SARS-CoV2
A Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) in Preventing SARS-CoV-2 Infection and COVID-19 in Nursing Home Residents and Staff
The purpose of this study is to evaluate whether LY3819253 given alone and with LY3832479 prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease - 2019 (COVID-19).
- Trial name
- BLAZE-2 (NCT04497987)
- Testing
- Bamlanivimab, Etesevimab
- Where
- 27 sites in United States
- Volunteers
- 1,180 people
- Sponsor
- Eli Lilly and Company
Alzheimer's Disease and Related Dementias
Smart Lighting for Nursing Home Residents With Dementia
This proposed study seeks to develop a smart ambient bright light (SABL) intervention to provide auto-controlled, consistent indoor lighting that incorporates natural daylight.
- Trial name
- NCT05825404
- Testing
- Smart Ambient Bright Light (SABL), Control
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Penn State University
Dementia, Infection, Bacterial
Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias
This is a 52-month study (8 months preparation; 36 months to conduct the trial; 8 months data analyses and manuscript preparation) of a cluster randomized controlled trial (RCT) of an intervention to improve infection management…
- Trial name
- TRAIN-AD (NCT03244917)
- Testing
- TRAIN-AD
- Where
- United States
- Volunteers
- 430 people
- Sponsor
- Hebrew SeniorLife
Accidental Falls/Prevention and Control
Nursing Home Prevention of Injury in Dementia (NH PRIDE)
The purpose of this study is to develop a consistent approach to prevent falls with injury in nursing home (NH) residents. A centralized Injury Liaison Service (ILS) will be developed and tested in four nursing home facilities…
- Trial name
- NH PRIDE (NCT04242186)
- Testing
- Injury Liaison Service
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Hebrew SeniorLife