Clinical trials: Nutrition, open to volunteers
Cardiovascular Diseases, Cardiovascular Risk Factors
The Effect of a Digital Heart Health App and Lifestyle Intervention for Heart Disease in Primary Care.
Despite the availability of medications, many people around the world continue to live with long-term health problems like heart disease, stroke and diabetes. In Canada, heart disease is a leading cause of death.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factors, Dyslipidemia, Cholesterol
- Trial name
- CHEAP (NCT06919302)
- Testing
- Digital Heart Health Program
- Where
- Canada
- Volunteers
- 1,100 people
- Sponsor
- University of Toronto
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
Developing Microbiome and Dietary Strategies Based on Chrono-nutrition for Targeting ADHD
Study objectives This project seeks to understand how an intervention based on time-restricted eating (ChronoFeeding or CF) can improve quality of life, behavior, sleep, and gut health in adults with ADHD (Attention Deficit…
- Trial name
- CronoNutriBiom (NCT07821060)
- Testing
- Circadian fasting
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Obesity & Overweight
OBE2026 - Effect of One Year Intensive Lifestyle Treatment in Children With ISO-BMI Over 30kg/m² and Their Families.
Obesity has increased significantly in recent decades and is starting earlier than before, even before school age. In 2023, 8% of Finnish boys aged 7-12 and 4% of girls were obese, while the corresponding figures for boys aged…
- Trial name
- NCT07738029
- Testing
- Lifestyle Management
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Tampere University Hospital
Overweight, Obesity
Transcutaneous Auricular Vagus Nerve Stimulation Combined With Lifestyle Intervention for Visceral Fat Reduction in Adults With Overweight or Obesity
This is a single-center, randomized, open-label controlled trial with blinded outcome assessment and data analysis. Fifty adults with overweight or obesity (body mass index [BMI] >= 24 kg/m2) and a sedentary lifestyle will be…
- Trial name
- taVNS (NCT07907029)
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), Standardized lifestyle program (calorie-restricted diet plus aerobic exercise)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
OSA - Obstructive Sleep Apnea, Obesity
A Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy
The aim of the study is to assess the efficacy and safety of XW003 injections in obese participants with OSA but not receiving PAP
- Trial name
- NCT07387094
- Testing
- XW003 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Diabetes Mellitus, Type 2, Obesity
Culturally Adapted Dietary Clinical Trial in PR
This project will determine whether a diet culturally adapted to adults in Puerto Rico can effectively decrease cardiometabolic risk factors.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- PRECISION (NCT05962372)
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Obesity, Weight Loss
Bariatric Embolization of Arteries for the Treatment of Nonalcoholic Steatohepatitis
Obesity is an epidemic in the US. With progression of obesity, Nonalcoholic steatohepatitis (NASH) has been a growing public health issue.
- Conditions
- Obesity, Weight Loss, Body Weight, Nonalcoholic Steatohepatitis
- Trial name
- NCT02933554
- Testing
- Embospheres Microspheres
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Keith Pereira, MD:
Prediabetes, Overweight , Obesity
Exercise, Chronotype, and Prediabetes
The goal of this clinical trial is to find out whether exercising at the right time of day, based on a person's natural body clock, leads to greater health benefits in people living with prediabetes.
- Trial name
- NCT07389005
- Testing
- Timing of exercise, Control
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- German Diabetes Center
Tonsillectomy, Bleeding
Postoperative Care After Tonsillectomy
Tonsillectomy is one of the most common surgical procedures performed on both pediatric and adult patients; it is frequently associated with significant postoperative pain, difficulty swallowing, and the risk of complications…
- Conditions
- Tonsillectomy, Bleeding, Nutrition, Healing
- Trial name
- ARAP (NCT07792057)
- Testing
- Nutrition and Hydration
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Hospital Felicio Rocho
Obesity
Involvement of the Gut Microbiota-brain Cross-talk in the Loss of Eating Control
Overweight and obesity are increasingly prevalent worldwide. These bodyweight disorders are closely related to deficiencies in the control of food intake.
- Trial name
- GMBTalk-Food (NCT05646901)
- Where
- Spain
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis
Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin…
- Conditions
- Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis, Chronic Inflammation
- Trial name
- NCT04232566
- Testing
- Bariatric surgery
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Bariatric Surgery Candidate
Preoperative Use of a Magnetically Controlled Capsule Endoscopy in Patients Undergoing Bariatric Surgery
The goal of this clinical trial is to test if a swallowable camera capsule can safely examine the upper digestive tract in people preparing for weight loss surgery.
- Conditions
- Obesity, Bariatric Surgery Candidate, Hypertension, Diabetes
- Trial name
- NAVICAM (NCT07587437)
- Testing
- Magnetically Controlled Capsule Endoscopy (MCCE)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jerry Dang
Low Muscle Strength, Malnutrition
Efficacy of Oral Nutritional Supplement in Community-Dwelling Adults Following Acute Care
The study aims to determine the effects of Oral Nutritional Supplement (ONS) added to usual care on body weight compared with usual care alone in community-dwelling adults aged 55 years and older who are at risk of malnutrition…
- Trial name
- NCT07753239
- Testing
- ONS, Standard of Care (SOC)
- Where
- 7 sites in Thailand
- Volunteers
- 304 people
- Sponsor
- Abbott Nutrition
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Fatty Liver Disease, Nonalcoholic
Investigation of the Efficacy of a Probiotic Mixture in Moderate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Mechanistic Trial
The goal of this clinical trial is to evaluate whether a specific probiotic mixture can improve liver health in adults with moderate metabolic dysfunction-associated steatotic liver disease (MASLD).
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Fatty Liver Disease, Nonalcoholic, Overweight (BMI > 25)
- Trial name
- NCT07193927
- Testing
- Lactiplantibacillus plantarum Probiotic Mixture
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- AB Biotics, SA
Morbid Obesity Requiring Bariatric Surgery
Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?
The goal of this observational study is to evaluate whether preoperative fat-free mass predicts post-operative weight loss in patients undergoing Roux-En-Y gastric bypass.
- Trial name
- FLAG (NCT07565051)
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University Hospital, Geneva
Type 2 Diabetes, Obesity
Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass
The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide.
- Conditions
- Type 2 Diabetes, Obesity, Semaglutide, GLP-1
- Trial name
- GLIMMER (NCT07272837)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Prader-Willi Syndrome, Hypothalamic Obesity
Tirzepatide in PWS, HO and GNSO
This research study is comparing the effectiveness of a weight loss medication called Tirzepatide in young adults with Prader-Willi Syndrome and/or hypothalamic obesity, as compared to young adults with obesity that is unrelated…
- Conditions
- Prader-Willi Syndrome, Hypothalamic Obesity, Obesity/Therapy
- Trial name
- NCT06901245
- Testing
- Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Grace Kim
Overweight, Obesity
Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin
The purpose of this study is to characterize the Influence of HDM1005 on gastric emptying and drug-drug interaction of HDM1005 and metformin, atorvastatin, warfarin, and digoxin in overweight/obese adult subjects.
- Trial name
- NCT07502001
- Testing
- Acetaminophen, Metformin, Warfarin
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Heart Failure, Overweight and Obesity
Mobile Applet for Weight Management in Obese Heart Failure Patients
The objective of this clinical trial is to investigate the effect of weight reduction through a diet management application and an intelligent weight scale on a composite cardiovascular endpoint in obese patients with heart…
- Conditions
- Heart Failure, Overweight and Obesity, Weight Loss, Heart Failure With Reduced Ejection Fraction
- Trial name
- IDEAL-HF (NCT06455878)
- Testing
- Full usage of diet management app group and with the full usage of an intelligent weight scale, Limited usage of diet management app group and with the limited usage of an intelligent weight scale
- Where
- 26 sites in China
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- Heart Health Research Center
Impaired Mobility
Nutrition Intervention for Older Adults and Research Training
Lack of effective interventions to improve diet quality among older urban adults represents a significant health problem. Simultaneously, enhancing the biomedical workforce is needed to meet growing US demands in research and…
- Trial name
- NIFOA-RT (NCT07898085)
- Testing
- Nutrition Intervention, Contact Control
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
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