Clinical trials: Nutrition Disorder
HIV-associated Enteropathy
Impact of SBI, a Medical Food, on Nutritional Status in Patients With HIV-associated Enteropathy
The purpose of the study is to evaluate the effectiveness of the oral nutritional therapy serum-derived bovine immunoglobulin protein isolate (SBI) 2.5 g twice a day (BID) and SBI 5.0 g versus placebo on supporting nutrient…
- Trial name
- NCT01828593
- Testing
- Serum-derived bovine immunoglobulin protein isolate (SBI)
- Where
- 10 sites in United States
- Volunteers
- 103 people
- Sponsor
- Entera Health, Inc
Type 2 Diabetes, Diabetes Mellitus Type 2
AIM-MET: AI-Guided Microbiome-Targeted Nutrition for Glycemic Improvement in Type 2 Diabetes
AIM-MET is a randomized clinical study testing whether a fixed microbiome-targeted nutritional product can improve blood sugar control in adults with type 2 diabetes when used in addition to usual stable diabetes treatment.
- Trial name
- AIM-MET (NCT07622628)
- Testing
- Microbiome-targeted oral food supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- ENBIOSIS BIOTECHNOLOGIES
Dietary Deficiency, Sodium
Cross-sectional, Non-randomized Observational Study to Assess the Frequency of Reduced Sodium Intake in the Primary Care Setting - LAXAP
This study is a cross-sectional epidemiological, observational study. It would be carried out in primary health care sites. The purpose of this study is estimating the percentage of patients aged 60 years or older who suffer from…
- Trial name
- LAXAP (NCT06121583)
- Where
- 14 sites in Spain
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- Casen Recordati S.L.
Obesity, Morbid
Duodenal-Ileal Diversion in Obese Patients Undergoing Primary Sleeve or Those With Inadequate Weight Loss After Sleeve
The objectives of this study are to assess the initial safety and device functionality of the SFM Anastomosis System including delivery systems when used to create a dual-path duodenal-ileal (D-I) diversion either during sleeve…
- Trial name
- NCT05064722
- Testing
- Self Forming Magnets (SFM)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- GI Windows, Inc.
Obesity
Phase 2a Obesity Study of Oral Doses of Oleoyl-Estrone (MP-101)
The purpose of this study is to evaluate the safety, preliminary efficacy, and pharmacokinetics of two 14-day cycles of escalating oral doses of MP 101 in 100 obese adult subjects.
- Trial name
- NCT00449202
- Testing
- oleoyl-estrone (MP 101)
- Where
- 3 sites in United States, Switzerland
- Volunteers
- 100 people
- Sponsor
- Manhattan Pharmaceuticals
Overweight, Obesity
A Study to Test Whether Multiple Doses of BI 456906 Have an Effect on Cardiac Safety in People With Overweight or Obesity
This study is open to adults between 18 and 55 years of age with overweight or obesity. The purpose of this study is to find out whether a medicine called survodutide (BI 456906) has an effect on cardiac safety.
- Trial name
- NCT06200467
- Testing
- BI 456906, Moxifloxacin
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity, Overweight or Obesity
A Phase 2b Study to Examine the Safety and Efficacy of Once-Weekly MET097 in Adults With Obesity or Overweight
This study is designed to test how well MET097, an active drug, works to treat individuals with obesity or overweight when compared to placebo. MET097 or placebo will be given to individuals weekly for 28 weeks.
- Trial name
- VESPER-1 (NCT06712836)
- Testing
- MET097
- Where
- 2 sites in United States
- Volunteers
- 239 people
- Sponsor
- Pfizer
Diabetes Mellitus, Type 2, Obesity
A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity
The main purpose of this study is to measure the safety and efficacy of tirzepatide in adult participants in India who have type 2 diabetes or who have obesity or overweight without type 2 diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Overweight
- Trial name
- NCT07438444
- Testing
- Tirzepatide
- Where
- 21 sites in India
- Volunteers
- 344 people
- Sponsor
- Eli Lilly and Company
Childhood Obesity
Josef Ressel Centre Perinatal Programming
Background: Metabolic imprinting through early childhood nutrition seems to play an important role in the aetiology of obesity. Overweight at age two and later in life is associated with excessive weight gain as early as three…
- Trial name
- JRP (NCT03634930)
- Testing
- observation
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Moenie van der Kleyn
Obesity
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
The purpose of this study is to evaluate the safety and tolerability of single and multiple subcutaneous (SC) doses of MBX 4291 in adults with obesity.
- Trial name
- NCT07142707
- Testing
- MBX 4291
- Where
- 4 sites in United States
- Volunteers
- 124 people
- Sponsor
- MBX Biosciences
Obesity/Overweight
Study of Pharmacokinetics and Safety of GZR18 Injection in Subjects With Renal Impairment and Normal Renal Function
This study adopts a multicenter, single-dose, open-label, and parallel design, which is aimed at assessing the PK and safety profiles of GZR18 Injection in subjects with normal renal function and those with mild, moderate or…
- Trial name
- NCT07141030
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Overweight and Obesity, Dyslipoproteinemia
Effect of Weight Management Programs on Cardiometabolic Risk Profile in Overweight Women
Aim of this prospective randomized study was to evaluate whether a diet with meal replacements can be as effective as a conventional energy-restricted modified diet on weight loss, body composition and cardiometabolic risk…
- Trial name
- FM-01 (NCT03109834)
- Testing
- Meal replacement (MR), Control (C), Verum
- Volunteers
- 105 people
- Sponsor
- Bonn Education Association for Dietetics r.A., Cologne, Germany
Overweight, Obesity
A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects
This study will examine the safety, tolerability, and body weight effect of subcutaneous pramlintide alone and in various combinations with the oral antiobesity agents sibutramine or phentermine in overweight and obese subjects.
- Trial name
- NCT00402077
- Testing
- pramlintide acetate, sibutramine, phentermine
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- AstraZeneca
Obesity
A Study to Test Whether Different Doses of BI 456906 Help People With Overweight or Obesity to Lose Weight
This study is open to adults, aged 18 to 75 years, with overweight or obesity. People with body mass index (BMI) of 27 or higher to join the study. People who have diabetes cannot participate.
- Trial name
- NCT04667377
- Testing
- BI 456906
- Where
- 43 sites in United States, Australia and 10 more
- Volunteers
- 387 people
- Sponsor
- Boehringer Ingelheim
Malnutrition
TOLER-ENT Study: A Study to Investigate the Tolerance of the High Energy, High Protein Formula Sondalis® HP 2 kcal
A multicentre, prospective, open-label, single arm study for 2 months, involving adult patients under poorly tolerated Home Enteral Nutrition (HEN).
- Trial name
- SONDALIS (NCT05429853)
- Testing
- Sondalis® HP 2 kcal (with or without fibre)
- Where
- 2 sites in France
- Volunteers
- 17 people
- Sponsor
- Société des Produits Nestlé (SPN)
Malnutrition
Hospital Discharge Oral Nutrition Support Trial
To investigate the effect of different strategies for managing malnutrition in the community
- Trial name
- NCT02051777
- Testing
- Oral Nutritional Supplement 1, Oral Nutritional Supplement 2, Dietary Advice
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Nutricia UK Ltd
Obesity/Overweight in Adult
Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects
This study is a multicenter, randomized, open-label, parallel-group phase III clinical trial comparing the efficacy and safety of GZR18 Injection and semaglutide (Wegovy®) in adult obese or overweight subjects, aiming to evaluate…
- Trial name
- NCT07150975
- Testing
- GZR18, Semaglutide(Wegovy® )
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Diabetes Mellitus
Investigate the Efficacy and Safety of GSK1070806 in Obese Subjects With T2DM
GSK1070806 is a humanised IgG1/kappa antibody which is directed against the soluble cytokine interleukin-18 (IL-18). The aims of this placebo controlled study are to evaluate the efficacy, safety, tolerability, pharmacokinetics…
- Trial name
- T2DM (NCT01648153)
- Testing
- GSK1070806
- Where
- 13 sites in Spain, United Kingdom
- Volunteers
- 37 people
- Sponsor
- GlaxoSmithKline
Obesity
Effectiveness of the Optifast Program Compared With a Reduced-energy Food Based Diet Plan on Body Weight
Compare percent change in loss of body weight between the OPTIFAST program and a food-based energy-deficit program
- Trial name
- Opti-WIN (NCT02635698)
- Testing
- Optifast, Food-Based
- Where
- 9 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Obesity
Effect of Diltiazem Administration on CP-945,598 Pharmacokinetics
A recently completed clinical drug interaction study of CP-945,598 with ketoconazole, a potent CYP3A inhibitor, showed that coadministration of CP-945,598 with ketoconazole results in an approximately 5-fold increase in…
- Trial name
- NCT00645463
- Testing
- CP-945,598
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
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