Clinical trials: Nutrition Disorder
Obesity
Effect of Obesity on Immune Response to Pneumovax 23
Pneumococcal infections are a leading cause of adult and childhood hospitalization and death. It has been shown that obese individuals are at higher risk for this bacterial infection.
- Trial name
- ROVE (NCT02471014)
- Testing
- Pneumovax 23, Blood tests, Questionnaires
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity
LEAP2 Kinetics in Healthy Individuals
The study aims to investigate the kinetics of the naturally occurring peptide liver-enriched antimicrobial peptide 2 (LEAP-2) in healthy volunteers.
- Trial name
- NCT04897984
- Testing
- Liver-enriched antimicrobial peptide 2
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes, Fatty Liver
Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women
Background: Vitamin E is an antioxidant that reduces the damaging effects of oxygen in the body. Most American men (90%) and women (96%) do not get enough vitamin E from their diets; however, the amount of vitamin E needed by the…
- Conditions
- Diabetes, Fatty Liver, Obesity, Healthy Volunteers
- Trial name
- NCT00862433
- Testing
- Alpha tocopherol, Vitamin E, Vitamin C
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Morbid, Weight Gain
Transit Bipartition After Sleeve Gastrectomy
Retrospective analysis of 100 morbidly obese patients who underwent a transit bipartition (TB) procedure ("Single Anastomosis Sleeve Ileal bypass") for inadequate weight loss or weight recidivism after a previous sleeve…
- Conditions
- Obesity, Morbid, Weight Gain, Bariatric Surgery Candidate
- Trial name
- TB-LSG (NCT04782648)
- Testing
- transit bipartition
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ruhr University of Bochum
Obesity, Genetic Disorder
Brain-Derived Neurotrophic Factor in Obesity and Brain Function
Background: Prader-Willi syndrome (PWS) and MC4R genetic mutations are two conditions that can cause problems with appetite regulation. People with PWS often have behavior and thinking problems.
- Conditions
- Obesity, Genetic Disorder, Mental Retardation, Developmental Delay
- Trial name
- NCT01517048
- Where
- 2 sites in United States, Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pregnancy in Obesity, Gestational Weight Gain
Optimizing GWG in Obese Pregnant Women: A Nationwide Real-World Study Using the U.S. Natality Cohort
The goal of this observational study is to find out which amount of weight gain during pregnancy is safest for women with obesity and their babies.
- Trial name
- GWG (NCT07796815)
- Testing
- Gestational Weight Gain
- Where
- United States
- Volunteers
- 1,600,000 people
- Sponsor
- Shanghai First Maternal and Infant Health Hospital affiliated to Tongji University Medical School
Obesity
Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight
Phase 2, multicenter, randomized, double-blind, placebo-controlled study evaluating once-weekly subcutaneous retatrutide (LY3437943) at multiple maintenance dose levels versus placebo in adults with obesity or overweight with…
- Trial name
- GZBF (NCT07467447)
- Testing
- Retatrutide (LY3437943), Standardized diet and physical activity counseling throughout the study.
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Hudson Biotech
Gestational Diabetes, Type2 Diabetes
The Belgian Diabetes in Pregnancy Follow-up Study
Gestational diabetes (GDM) is a form of diabetes that develops during pregnancy. GDM is associated with increased risks for pregnancy complications such as macrosomia s and preterm delivery.
- Conditions
- Gestational Diabetes, Type2 Diabetes, Obesity
- Trial name
- BEDIP-FUS (NCT04429958)
- Testing
- GDM
- Where
- 5 sites in Belgium
- Volunteers
- 630 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity / Overweight
Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese Patients
This is an observational cohort study. The primary objective is to analyze the dynamic changes in gut microbiota and metabolic profiles in obese patients treated with Tirzepatide.
- Trial name
- NCT07847515
- Testing
- Tirzepatide
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Mild Cognitive Impairment, Obesity
Caloric Restriction in Obese Patients With Mild Cognitive Impairment: Effects on Adiposity, Comorbidity and Cognition
Obesity has been associated with cognitive impairments, lower blood flow, metabolic activity and brain volume. Obesity in adulthood is a risk factor for Alzheimer's disease in the elderly.
- Trial name
- NCT01286389
- Testing
- medical care, caloric restriction
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Parenteral Nutrition Associated Cholestasis
Compassionate Use of an Intravenous Fish Oil Emulsion in Infants With Cholestasis
The study will evaluate the safety and efficacy of an intravenous fish oil emulsion (omegaven) in infants with parenteral nutrition associated cholestasis.
- Trial name
- NCT01601652
- Testing
- Omegaven
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Arthur J De Lorimier
Overweight, Obesity
The Effect of a Multi-component Weight Management Program on Appetite, Food Preference and Body Weight
The aim of the current study is to demonstrate that a commercial weight management diet (i.e. low energy density) influences satiation, hunger and satiety and leads to lower energy intake during ad-libitum meals and over a full…
- Conditions
- Overweight, Obesity, Sedentary Lifestlye
- Trial name
- SWSS (NCT02012426)
- Testing
- Weight management program
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Pancreatic Cancer
Sequential Nutrition Intervention for Pancreatic Cancer Patients Undergoing CyberKnife Radiotherapy
This study aims to evaluate the clinical value of a structured nutritional support program for patients with pancreatic cancer undergoing CyberKnife radiotherapy.
- Trial name
- NCT07057843
- Testing
- Sequential Nutrition Intervention, Enteral Nutrition Emulsion, Routine Nutritional Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Hebei Medical University
Obesity (BMI>30), Obesity (BMI > 35)
FABP4 Response After Roux-en-Y Gastric Bypass
This retrospective observational cohort study examined serum fatty acid-binding protein 4 (FABP4) dynamics in 28 adults who underwent Roux-en-Y gastric bypass (RYGB), followed at baseline, 3 months, and 6 months.
- Conditions
- Obesity (BMI>30), Obesity (BMI > 35), Insulin Resistance, Bariatric Surgery
- Trial name
- FABP4-RYGB (NCT07774208)
- Volunteers
- 28 people
- Sponsor
- Istanbul University
Childhood Obesity Prevention
Digitally Delivered Child Obesity Prevention for Parents in Home Visiting Programs
The goal of this clinical trial is to determine feasibility and acceptability of a digitally-based obesity prevention intervention for mothers of infants participating in a home visitation program.
- Trial name
- NCT07230808
- Testing
- digital intervention + home visiting curriculum, Home visiting curriculum
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity
Energy Expenditure of High Intensity Functional Training
The purpose of this study is to assess the energy expenditure and intensity of a High Intensity Functional Training (HIFT) session in overweight and obese adult men and women.
- Trial name
- NCT02526108
- Testing
- HIFT
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Overweight, Obesity
Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0
The primary objective of the project is to adapt and implement a combined weight management intervention (an online program plus coaching and patient navigator support) across multiple settings and a diverse cross-section of…
- Trial name
- PROPS2 (NCT05553925)
- Testing
- Online Weight Management Program with Coaching and Patient Navigator Support
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Heart Failure
Nutrition Intervention to Decrease Symptoms in Patients With Heart Failure
The purpose of is to test the effects of a 6-month nutrition intervention of dietary sodium reduction combined with supplementation of lycopene and omega-3 fatty acids on heart failure symptoms, health-related quality of life…
- Trial name
- NIHFT (NCT01733017)
- Testing
- Sodium reduction, omega 3 and lycopene supplements, rice bran oil capsules
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Terry Lennie
Obesity
Building Social Networks to Enhance Postpartum Weight Loss and Appropriate Infant Feeding Practices
The purpose of this study is to examine whether we can use social networks to spread health information and health behaviors that 1) support women in returning to their pre-pregnancy weight after delivery; and 2) promote healthy…
- Trial name
- NCT01081340
- Testing
- Social network building intervention, Home visit
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Obesity
Dietary Lipids, Energy Expenditure and Obesity Biomarkers
The purpose of this study is to determine whether the modulation of dietary lipids are effective in the treatment of obesity and comorbidities.
- Trial name
- NCT02656940
- Testing
- Group 1 - diet rich in n-3 and n-6 PUFA, Group 2 - diet rich in MUFA
- Volunteers
- 32 people
- Sponsor
- Universidade Federal do Rio de Janeiro
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