Clinical trials: Nutrition and Energy Balance
Obesity
Protein Nutrition During Weight Loss
The purpose of this study is to minimize the loss of lean body mass that occurs during a weight-loss program in obese people by changing the nature of ingested protein and the pattern of protein feeding
- Trial name
- SURPROL-CF-H (NCT00690781)
- Testing
- Pulse casein feeding during energy restriction, Spread casein feeding during energy restriction, Pulse milk soluble protein feeding during energy restriction
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Obesity (Disorder)
Iron Absorption in The Low Oxygen Exposure and Weight Status (LOWS) Study
Declines in iron status are common in those with obesity and may be due to obesity-related chronic inflammation; however, the effects of reducing inflammation following diet-induced weight loss on iron metabolism are poorly…
- Trial name
- LOWS-IRON (NCT07542873)
- Testing
- Normobaric hypoxia (NH), Normobaric normoxia (NN)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Pennington Biomedical Research Center
Diabetes Mellitus, Type II, Obesity
A Study to Evaluate the Effect of MEDI0382 on Energy Balance in Overweight and Obese Participants With Type 2 Diabetes Mellitus
An exploratory study to evaluate the effect of MEDI0382 on energy balance in overweight and obese participants with type 2 diabetes mellitus
- Trial name
- NCT03596177
- Testing
- MEDI0382
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- MedImmune LLC
Obesity
Potato Consumption and Energy Balance
A randomized, clinical trial will be performed to assess changes in body weight and fat mass with daily potato consumption versus a calorie-matched snack of almonds.
- Trial name
- NCT03518515
- Testing
- White potato (french fries), White potato (French fries), +seasoning, Almond
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Melanocortin Obesity Syndrome, MCOS
Atomoxetine in Melanocortin Obesity Syndrome
This is a phase 2 randomized placebo-controlled crossover trial to determine the safety and efficacy of atomoxetine for treating obesity caused by loss-of-function variants in the melanocortin-4 receptor (MC4R), the most common…
- Trial name
- MCOS (NCT06899178)
- Testing
- Atomoxetine
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Huntington Disease
Energy Balance in Huntington's Disease. A Multidisciplinary Study Approach for a Complex Problem (BEHD-EM)
The study was conducted at the University Isabel I, Burgos in collaboration with the Hospital Universitario Burgos, Spain, through the creation of a multidisciplinary research team including graduates in physical activity and…
- Trial name
- BEHD-EM (NCT05250323)
- Testing
- observational tests in face-to-face visit
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario de Burgos
Obesity
Deep Brain Stimulation Effects in Patients With Chronic Refractory Obesity
This is a pilot study to evaluate the safety and efficacy of deep brain stimulation (DBS) of the lateral hypothalamic area (LHA) as a treatment for chronic refractory obesity.
- Trial name
- NCT04453020
- Testing
- DBS of the LHA
- Where
- United States
- Sponsor
- donald whiting
Environmental Enteric Dysfunction (EED), Malnutrition
The Maternal EED Study
Undernutrition among women of reproductive age is more common in South Asia than in any other region. In South Asia, the prevalence of maternal undernutrition varies between 10 and 40%.
- Conditions
- Environmental Enteric Dysfunction (EED), Malnutrition, Women of Reproductive Age, Gut Microbiota
- Trial name
- NCT05862363
- Testing
- Microbiota-directed balanced energy protein (MD-BEP), Ready-to-use supplementary food-balanced energy protein (RUSF-BEP), Esophagogastroduodenoscopy (EGD)
- Where
- Bangladesh
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Nutrition and Energy Balance
Acute Responses to Dietary Carbohydrate Manipulation
Sugar is perceived negatively, leading to government taxation and targets to reduce consumption. These actions have been taken based on the limited evidence that high-sugar diets are associated with greater total energy intake.
- Trial name
- NCT03509610
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Bath
Critical Illness
Impact of Supplemental Parenteral Nutrition in ICU Patients on Metabolic, Inflammatory and Immune Responses
Having previously demonstrated that supplemental parenteral nutrition to complete an insufficient enteral nutrition (EN) between D4 and D8 improves outcome after critical illness, by reducing infectious complications, the present…
- Trial name
- SPN2 (NCT02022813)
- Testing
- Supplemental parenteral nutrition (SPN)
- Where
- 2 sites in Switzerland
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Small for Gestational Age at Delivery, Gestational Weight Gain
BEP Targeting Strategies in Ethiopia
The goal of this randomized effectiveness study is to evaluate the different targeting strategies for the delivery of balanced energy and protein (BEP) supplements among pregnant women in Addis Ababa, Ethiopia.
- Conditions
- Small for Gestational Age at Delivery, Gestational Weight Gain, Stillbirth, Preterm Birth
- Trial name
- BEP (NCT06125860)
- Testing
- Targeted BEP based on baseline nutritional status, Targeted BEP based on baseline nutritional status and monthly GWG monitoring, Universal BEP
- Where
- Ethiopia
- Volunteers
- 7,851 people
- Sponsor
- Harvard School of Public Health (HSPH)
Obesity
Comparison of 1 vs 3 Sets of Resistance Training on Muscular Hypertrophy
This study is designed to investigate the effects of two levels of resistance weight training on body composition, energy expenditure, and energy intake in men and women. The weight training will take about one hour to complete.
- Trial name
- NCT01107691
- Testing
- Amount of resistance offered in training
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Overweight and Obesity
Is Monitoring Activity Important for Short- and Long-term Weight Loss?
This study is comparing the effectiveness of two techniques for monitoring physical activity and energy balance on long-term weight management (two years).
- Trial name
- UHPAWS (NCT00544245)
- Testing
- Self monitoring of estimated energy balance
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Hawaii
Overweight, Obesity
An Intergenerational Community Based Participatory Research (CBPR) Intervention to Reduce Appalachian Health Disparities
The study purpose is to evaluate the effectiveness of a culturally appropriate, faith-placed lay health advisor intervention aimed at increasing fruit and vegetable intake and physical activity among intergenerational Appalachian…
- Trial name
- NCT01373307
- Testing
- LHA-delivered energy balance classes/activities
- Where
- United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Nancy Schoenberg
Overweight and Obesity
Circadian Timing, Information Processing and Energy Balance Study
This study design will test biological and behavioral mechanisms in the cross-sectional analyses and determine the prospective effects of circadian alignment and sleep on changes in cardiometabolic risk factors.
- Trial name
- TIME (NCT04759755)
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity
Positive Energy I Through Overfeeding
The purpose of this trial is to examine the metabolic and behavioral effects of a positive energy balance induced by adding food to the usual level of activity.
- Trial name
- NCT01653145
- Testing
- Diet A, Diet B, Diet C
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Fetal Growth Retardation, Low Birth Weight
BEP Supplementation Research in Bangladesh (JiVitA-BEP-IR)
The primary aim of the study is to evaluate the effect of fortified balanced energy and protein (BEP) supplementation vs. control (multiple micronutrient supplement, MMS) without targeting and with targeting (either by low…
- Conditions
- Fetal Growth Retardation, Low Birth Weight, Preterm Birth, Gestational Weight Gain
- Trial name
- Target-BEP (NCT05576207)
- Testing
- Balanced energy and protein supplement for pregnant women, Multiple Micronutrient Supplement for pregnant women
- Where
- Bangladesh
- Volunteers
- 3,390 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Overweight, Obesity
Effects of a Wholegrain Diet on Body Composition and Energy Balance
The purpose of this study is to compare a diet containing whole grains versus an energy matched diet using refined grains on body composition and metabolism.
- Conditions
- Overweight, Obesity, Pre-diabetic
- Trial name
- NCT01411540
- Testing
- Whole grains
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Obesity
Intranasal Glucagon and Energy Balance
People who are overweight often find it difficult to lose weight through diet and medications because weight loss reduces the amount of energy spent by the body and increases appetite.
- Trial name
- INGEB (NCT03650582)
- Testing
- Glucagon
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Obesity
Integrating Quantitative Energetics Determines the Microbiome's Contribution to Energy Balance
We propose to study the role of the gut microbiome in the development of obesity, and whether we can change the microbiome's contribution to host energy balance through diet.
- Trial name
- NCT02939703
- Testing
- Diet
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute