Clinical trials: Nutritional Deficiencies
Acute Malnutrition in Childhood, Wasting
Treatment of Acute Malnutrition in Outpatient Care Services in Venezuela: a Prospective Cohort Research
The goal of this observational study is to compare the effectiveness, safety, and efficiency of the simplified protocol, which includes the following three modifications: a) use of a single treatment product (RUTF), b) reduced…
- Conditions
- Acute Malnutrition in Childhood, Wasting, Child Malnutrition
- Trial name
- NCT06287827
- Testing
- Simplified protocol, Standard protocol
- Where
- 4 sites in Venezuela
- Volunteers
- 299 people
- Sponsor
- UNICEF - Venezuela
Motor Neuron Disease, Amyotrophic Lateral Sclerosis (ALS)
Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease
The clinical primary hypothesis is that there will be a difference between a Cannabis Sativa extract and placebo in their effect on spasticity in Motor Neuron Disease (MND) patients with signs of involvement of the upper motor…
- Trial name
- CANALS (NCT01776970)
- Testing
- Cannabis Sativa extract Oromucosal spray
- Where
- 4 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Ospedale San Raffaele
Inflammatory Bowel Disease (IBD)
Clinical Investigation of MYIBDDiet App Developed for Inflammatory Bowel Disease (IBD) Patients to Self-manage Their Diet
The goal of this clinical trial is to learn if an app designed for diet education can help patients with inflammatory bowel disease (IBD) learn about healthy eating.
- Trial name
- NCT06683105
- Testing
- MyIBDDiet app
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Amyotrophic Lateral Sclerosis
Impact of Nuedexta on Bulbar Physiology and Function in ALS
Nuedexta is FDA approved for the treatment of pseudobulbar affect in ALS patients and anecdotal reports of improvements in speech, salivation or swallowing have been reported.
- Trial name
- NCT03883581
- Testing
- dextromethorphan HBr and quinidine sulfate
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Florida
Amyotrophic Lateral Sclerosis (ALS)
Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS Patients
The objective is to compare the efficacy and safety of masitinib in combination with riluzole versus matched placebo in combination with riluzole for the treatment of Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT07174492
- Testing
- Masitinib 4.5 mg/kg/day, Riluzole (100 mg)
- Where
- Greece
- Volunteers
- 412 people
- Sponsor
- AB Science
Alzheimer's Disease
Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease
In AD, tau protein is abnormally hyperphosphorylated. Significant changes of hyperphosphorylated tau levels in CSF are found in AD patients.
- Trial name
- NCT00800709
- Testing
- Memantine
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Shanghai Mental Health Center
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease
Ten patients with motor neurone disease (MND, also known as amyotrophic lateral sclerosis or ALS) will be successively enrolled to one of two dose levels of IC14 (human chimeric monoclonal anti-CD14) intravenously for four doses.
- Trial name
- NCT03487263
- Testing
- IC14
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Implicit Bioscience
Thrombocytosis, Iron-Deficiency Anemia
Ferinject® in Patient With Thrombocytosis Secondary to Inflammatory Bowel Disease (IBD)
The aim of this study is to show the benefits for patients, with a high platelet count, iron deficiency and IBD, receiving intravenous iron therapy.
- Trial name
- NCT00882414
- Testing
- FERINJECT® (Ferric carboxymaltose)
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Vifor Pharma
Malnutrition
Compliance With a High Energy Content, Low Volume Oral Nutritional Supplement
This study aims to investigate the compliance of high-energy, low-volume oral nutritional supplements (ONS) compared to equivalent high-energy standard ONS (control) in participants at risk of malnutrition.
- Trial name
- NCT05609006
- Testing
- High-Energy, Low-Volume ONS, High-Energy Standard ONS
- Where
- 2 sites in Spain
- Volunteers
- 73 people
- Sponsor
- Danone Specialized Nutrition
Transthyretin Amyloidosis, Carpal Tunnel Syndrome
Transthyretin Cardiac Amyloidosis in Patients With Idiopathic Carpal Tunnel Syndrome Referred for Release Surgery
This study will determine the prevalence of transthyretin amyloidosis in pathology of the transverse carpal ligament and cardiac involvement using natriuretic peptides, electrocardiography and echocardiography in patients…
- Trial name
- PRATHYC (NCT04611204)
- Testing
- Descriptive cohort
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Toulouse
Amyloidosis
A Study of NPT189 in Healthy Subjects
The purpose of the study is to evaluate the safety and tolerability of single dose of NPT189 in healthy volunteers. The study will also evaluate the pharmacokinetic characteristics of NPT189.
- Trial name
- NCT03610035
- Testing
- NPT189
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Proclara Biosciences, Inc.
Vitamin B6 Deficiency
Vitamin B6 Dependence of One-Carbon Metabolism
Marginal vitamin B6 deficiency, which occurs commonly worldwide, leads to a cellular deficiency of the coenzyme pyridoxal phosphate (PLP).
- Trial name
- NCT00877812
- Testing
- Arm 1 glycine and leucine, Arm 2 Intervention of Serine and methionine infusion
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Florida
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Aging, Polypharmacy
Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.
In this study, the investigators will investigate and characterize acute medical patients in order to optimize patient courses in the acute care departments, especially with regard to polypharmacy and undernourishment.
- Conditions
- Aging, Polypharmacy, Malnutrition, Inflammation
- Trial name
- FAM-CPH (NCT03052192)
- Where
- Denmark
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Malnutrition
Tolerance and Compliance of a High Caloric, High Protein Oral Nutritional Supplement - Free Intake
The aim of the study is to assess gastro-intestinal tolerance, palatability, compliance, and use of a high caloric, high protein oral nutritional supplement (ONS) in elderly people
- Trial name
- NCT02938234
- Testing
- High caloric, high protein ONS
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Fresenius Kabi
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Bell Palsy, Vitamin D Deficiency
The Effect Vitamin D on the Recovery Rate of Bell Palsy
Patients aged between 18-65 who visit the Physical Medicine and Rehabilitation outpatient clinic diagnosed with Bell Palsy will be included in the study.
- Conditions
- Bell Palsy, Vitamin D Deficiency, Facial Paralysis
- Trial name
- NCT05997199
- Testing
- Vitamin D replacement
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Umraniye Education and Research Hospital
Adherence, Gastrointestinal Cancer
Adherence to Exercise and Dietary Intervention in Cancer Patients
Intervention programs in cancer patients have been proposed with the aim of improving outcome. Bearing in mind that compliance is a limiting factor to the benefit provided from exercise and diet, assessing adherence to these…
- Trial name
- CEDI (NCT05237921)
- Testing
- Combined Exercise and Dietary Intervention (CEDI), Standard Care
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Hospital Beatriz Ângelo
Anemia of Pregnancy, Iron Deficiency Anemia
Liposomal Iron 30 mg Supplement in Non-anemic Pregnant Females
Protocol Summary: Liposomal Iron Supplementation in Non-anemic Pregnant Females This observational study aims to evaluate the efficacy and safety of daily liposomal iron supplementation (30 mg) in non-anemic pregnant women during…
- Trial name
- LITSNPF (NCT06669052)
- Testing
- 30 mg liposomal iron, capsules
- Volunteers
- 714 people, healthy volunteers welcome
- Sponsor
- Orchidia pharmaceutical Industries
Vitamin D Deficiency, Thoracic Surgery
Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Intake Level
Our research group has shown that almost all children with congenital heart disease (CHD) are vitamin D deficient following heart surgery.
- Conditions
- Vitamin D Deficiency, Thoracic Surgery, Pediatric Disorders, Heart Defects, Congenital
- Trial name
- HICCUPS 2 (NCT01838447)
- Testing
- Cholecalciferol
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Children's Hospital of Eastern Ontario
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