Clinical trials: Nutritional Deficiencies
Overweight and Obesity, Vitamin D Deficiency
Magnesium and Vitamin D Supplementation and Cardiometabolic Outcomes
The purpose of this study is to investigate the effects of a combined vitamin D and magnesium supplementation on parathyroid hormone and cardiometabolic health in persons living with obesity.
- Conditions
- Overweight and Obesity, Vitamin D Deficiency, Magnesium Deficiency, Cardiovascular Risk Factor
- Trial name
- NCT03134417
- Testing
- Vitamin D and magnesium, Vitamin D
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Drexel University
Iron Deficiency, Heart Failure
Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron.
Iron deficiency, independent of anemia, appears to increase morbidity and mortality as well as impairing health-related quality of life in chronic heart failure (CHF), and these effects are compounded when patients also…
- Conditions
- Iron Deficiency, Heart Failure, Chronic Kidney Disease
- Trial name
- NCT02392910
- Testing
- Iron Sucrose
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Aleman
Amyotrophic Lateral Sclerosis
Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants With SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS)
This is the study of AMT-162 in Participants with SOD1-ALS and is designed to evaluate the safety, tolerability, and exploratory efficacy of intrathecally administered gene therapy AMT-162.
- Trial name
- NCT06100276
- Testing
- AMT-162
- Where
- 12 sites in United States, Sweden
- Volunteers
- 20 people
- Sponsor
- UniQure Biopharma B.V.
Chronic Kidney Disease
Determinants of Muscle Strength in Chronic Kidney Disease
Aim of this study is to determine in chronic kidney disease patients: the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle…
- Trial name
- NCT02806089
- Testing
- Handheld dynamometer, Creatinine index, Electrical bioimpedance analysis
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Cardiomyopathy
Characteristics of Patients With Amyloidosis & Heart Failure Being Evaluated for a Heart Transplant
The purpose of this study is to describe the characteristics of patients with amyloidosis and severe heart failure being evaluated for cardiac and stem cell transplantation.
- Trial name
- NCT00456040
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Iron-deficiency, Iron Deficiency Anemia
Effects of Enhancers and Inhibitors on Absorption From Iron Supplements
Iron deficiency (ID) is a major public health problem worldwide and oral iron supplementation can be an effective strategy to treat and prevent ID.
- Trial name
- NCT05414474
- Testing
- Reference, Ascorbic acid (AA) 500 mg, Ascorbic acid (AA) 80 mg
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Newborn Resuscitation, Severe Malnutrition
Enhancing Pediatric Acute Care Through Adaptive E-Learning and In-Person Skills Practice in Tanzania
The goal of this clinical trial is to evaluate whether the integration of in-person skills practice (ISP) with an adaptive e-learning platform can improve refresher learning progress (RLP) among healthcare providers in pediatric…
- Conditions
- Newborn Resuscitation, Severe Malnutrition, Severe Malaria, Severe Pneumonia
- Trial name
- PACE (NCT06635733)
- Testing
- Rhapsode Capable™ Platform (Intervention Group), Paper-based ISP (Control Group)
- Where
- Tanzania
- Volunteers
- 100 people
- Sponsor
- Stanford University
Mitochondrial Diseases, Mitochondrial Myopathies
Nutritional Assessment in Mitochondrial Cytopathy
The aim of this study is to assess nutritional intake (quantitatively and qualitatively), nutritional state and body composition of patients suffering from mitochondrial cytopathy, compared to healthy controls.
- Conditions
- Mitochondrial Diseases, Mitochondrial Myopathies, Mitochondrial Cytopathies
- Trial name
- NAMITO (NCT02375438)
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypercholesterolemia, Cognitive Dysfunction
The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions
The study evaluates if the relationship between total serum cholesterol is dependent on the total serum homocysteine. Fasting blood samples will taken from participants and two batteries of cognitive scales will be used to asses…
- Conditions
- Hypercholesterolemia, Cognitive Dysfunction, Hyperhomocysteinemia
- Trial name
- NCT03631238
- Testing
- Blood sampling for total cholesterol and homocysteine and cognitive assessment by psychometric tests.
- Where
- Egypt
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Assiut University
Malnutrition
Validation of the STAMP Screening Tool For Pediatric Nutritional Risk
Background: Insufficient nutritional intake, with or without concomitant morbidity, leads to weight loss or insufficient weight gain, is related to an increase in morbidity and mortality and exposes the child to medical…
- Trial name
- STAMP2 (NCT01718769)
- Testing
- questionnaire STAMP
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Meir Medical Center
Vitamin D Deficiency, Malnutrition
Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition
Multi-center, prospective, randomized, controlled study to verify the clinical effectiveness of K / DOQI guidelines. The efficiency and safety of Vitamin D2 and low protein diet treatment for prevention and treatment of CKD-MBD…
- Trial name
- NCT02005302
- Testing
- 1,25(OH)2 Vitamin D3, Vitamin D2, low protein diet
- Where
- 5 sites in China
- Volunteers
- 600 people
- Sponsor
- Wenhu Liu
PSP, CBD
Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders
The investigators aim to learn more about symptoms suggestive of a neurodegenerative process.
- Conditions
- PSP, CBD, PCA, LPA
- Trial name
- AND1 (NCT04680130)
- Testing
- C-11 PiB, AV1451 Tau, C-11 ER176
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
REM Sleep Behavior Disorder, Parkinson Disease
North American Prodromal Synucleinopathy Consortium
This study will enroll participants with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Disease, Dementia With Lewy Bodies
- Trial name
- NAPS (NCT03623672)
- Where
- 10 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- Washington University School of Medicine
Amyotrophic Lateral Sclerosis
An Intermediate Size Expanded Access Protocol of AMX0035 for ALS
The Expanded Access Program will provide access and assess the safety of AMX0035 for the treatment of people living with ALS.
- Trial name
- NCT05286372
- Testing
- AMX0035
- Where
- 21 sites in United States, Puerto Rico
- Sponsor
- Amylyx Pharmaceuticals Inc.
Sarcopenia, Cirrhosis, Liver
LIver FRAilty Management IN Cirrhosis (LIFRAMIN)
The goal of this clinical trial is to compare food for special medical purposes (Aminolife Plus, by Piemme Pharmatech) vs. placebo in improving muscle mass and function in a cohort of cirrhotic patients.
- Conditions
- Sarcopenia, Cirrhosis, Liver, Malnutrition; Protein
- Trial name
- LIFRAMIN (NCT06573229)
- Testing
- Aminolife Plus by Piemme Pharmatech, Italy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
End Stage Renal Disease
Effects of Nutritional Supplementation on Protein and Energy Homeostasis in Malnourished Chronic Hemodialysis Patients
The goal of this study is to evaluate the metabolic effects of concomitant use of three consecutive doses of recombinant human growth hormone over three days and exercise during continuous nutrient infusion in chronic…
- Trial name
- NCT00244075
- Testing
- nutritional supplement, recombinant human growth hormone (rcGH), exercise
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt University
Amyloidosis
Biodistribution of 89Zirconium-labelled GSK2398852 Using PET Imaging
The principal aim of this study is to investigate the cardiac uptake of 89Zr-GSK2398852 in subjects with transthyretin cardiomyopathy amyloidosis (ATTR-CM), and its biodistribution to other organs.
- Trial name
- NCT03417830
- Testing
- GSK2315698 (CPHPC), GSK2398852 (unlabeled anti-SAP mAb), 89Zr-GSK2398852 (89Zr-labeled anti-SAP mAb)
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Weight Loss
The Undernourished Patient: Prevention and Treatment
The purpose of this study is to determine whether a nutrition intervention during a rehabilitation stay followed by nutritional advice after discharge, can improve the nutritional status of the patients after 3 months.
- Trial name
- NCT01632072
- Testing
- Nutritional support
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Oslo
Congenital Heart Disease, Thiamine Deficiency
The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease
Currently, research on the effect of thiamine administration during transcatheter closure on the structure and function of the left ventricle by examining levels of matrix metalloproteinase-9 and tissue inhibitor of…
- Conditions
- Congenital Heart Disease, Thiamine Deficiency, Patent Ductus Arteriosus, Ventricular Septal Defect
- Trial name
- NCT06298344
- Testing
- Thiamine
- Where
- Indonesia
- Volunteers
- 86 people
- Sponsor
- Universitas Sumatera Utara
Autonomic Nervous System Disease, Amyloid Neuropathies
Autonomic Evaluation of Patients With Hereditary Amyloidotic Cardiomyopathy: Hereditary Amyloidotic Heart Disease
Transthyretin amyloidosis exhibits a variety of possible phenotypes, the hereditary neurological form being the most commonly found and studied (familial amyloidotic polyneuropathy or FAP), which can present from oligosymptomatic…
- Trial name
- NCT05087953
- Testing
- Head-Up Tilt table test, Heart Rate Variability
- Where
- 3 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
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