Clinical trials: Nutritional Deficiency in Pregnancy (Disorder)
Chronic Renal Failure
Serum Uremic Toxins and Histological Findings of the Blood Vessels in Dialysis Patients
Patients treated by chronic renal replacement therapy are exposed to cardiovascular problems and suffer from an accelerated and sever atherosclerosis.
- Trial name
- NCT00412139
- Where
- North Macedonia
- Volunteers
- 100 people
- Sponsor
- University of Skopje
Overactive Bladder, Vitamin D Deficiency
The Role of Urinary RhoA, NGF, and BDNF Levels in Overactive Bladder and Vitamin D Deficiency
The primary aim of this study is to evaluate the role of three specific urinary proteins-RhoA, Nerve Growth Factor (NGF), and Brain-Derived Neurotrophic Factor (BDNF)-as potential biomarkers for the diagnosis and follow-up of…
- Trial name
- NCT07513363
- Testing
- Urotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tarik Emre Sener
End-Stage Renal Disease
Vitamin D3 Supplementation in Dialysis Patients
Vitamin D deficiency is highly prevalent among dialysis patients, and has been associated with cardiovascular risk factors such as increased aortic pulse wave velocity, blood pressure, inflammation, and brain natriuretic peptide.
- Trial name
- NCT01312714
- Testing
- Cholecalciferol
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Regional Hospital Holstebro
X-linked Hypophosphatemia (XLH)
Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Pediatric Chinese Patients With XLH
The purpose of this study is to assess the safety, pharmacokinetics and efficacy of KRN23 in pediatric Chinese patients with XLH
- Trial name
- NCT04842032
- Testing
- KRN23
- Where
- 5 sites in China
- Volunteers
- 28 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Hereditary Cancer Syndrome
CfDNA in Hereditary And High-risk Malignancies 2
The goal of this study is to understand the performance of an experimental blood test that aims to detect early tumors in patients with hereditary cancer syndromes.
- Trial name
- CHARM2 (NCT06726642)
- Testing
- Cell-free DNA analysis
- Where
- 8 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- University Health Network, Toronto
X-linked Hypophosphatemia
Anti-FGF23 (Burosumab) in Adult Patients With XLH
X-linked hypophosphatemia (XLH) rare genetic disorder due by inactivating mutations in the PHEX gene leading to increased levels in FGF-23.
- Trial name
- BurGER (NCT04695860)
- Testing
- Burosumab
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Wuerzburg University Hospital
Colon Cancer
Combined Colon and Endometrial Cancer Screening in Women With HNPCC
Primary Objectives: To test the feasibility of combined colon and endometrial cancer screening in women with increased risk for colon and endometrial cancer. To measure patient satisfaction for the combined procedure.
- Trial name
- NCT00510796
- Testing
- Interview
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Anemia, Iron Deficiency, Acute Kidney Injury
Effect of Intravenous Iron Repletion on Renal Function in Patients With Iron Deficiency and Acute Kidney Injury
This clinical trial aims to carry out research on the effect on hemoglobin and renal function of intravenous administration of iron dextran as a repletion strategy in patients with iron deficiency anemia and acute kidney injury…
- Trial name
- NCT05960227
- Testing
- Iron dextran
- Where
- 2 sites in Mexico
- Volunteers
- 120 people
- Sponsor
- Hospital Civil de Guadalajara
Secondary Hyperparathyroidism, Chronic Kidney Disease
Study to Assess Patient Management Practices and Quality of Life With Paricalcitol Capsules in the Treatment of Secondary Hyperparathyroidism in Stage 3-5 Chronic Kidney Disease Patients Not Yet on Dialysis
Paricalcitol capsules (Zemplar®) received marketing authorization in Sweden in late 2007 for the prevention and treatment of secondary hyperparathyroidism in patients with Stage 3 \& 4 Chronic Kidney Disease (CKD).
- Trial name
- CAPITOL (NCT01265992)
- Where
- 10 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Polycystic Ovary Syndrome, Insulin Resistance
Endocrine and Menstrual Disturbances in Women With Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive age women, which causes disordered follicle growth and ovulation resulting in infertility.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Vitamin D Deficiency, Obesity
- Trial name
- EMDPCOS (NCT03652987)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- St George's, University of London
Solid Cancers, NSCLC (Advanced Non-small Cell Lung Cancer)
An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors
This is a Phase Ib/II clinical study. The Phase Ib dose-escalation study aims to evaluate and determine the recommended Phase II dose (RP2D) of TCC1727 in combination with benmelstobart /olaparib /topotecanfor patients with…
- Conditions
- Solid Cancers, NSCLC (Advanced Non-small Cell Lung Cancer), Gastric (Stomach) Cancer, Endometrial Cancer
- Trial name
- NCT07371663
- Testing
- TCC1727 tablet 90mg, TCC1727 tablet 120mg, TCC1727 tablet 160mg
- Where
- 3 sites in China
- Volunteers
- 266 people
- Sponsor
- Beijing Tide Pharmaceutical Co., Ltd
Neonatal Death, Infectious Disease
Vitality in Infants Via Azithromycin for Neonates Trial
Nearly half of child deaths occur during the neonatal period, and 80% of those occur in babies with low birthweight. Although tremendous progress has been made towards reducing under-five mortality globally, declines in neonatal…
- Conditions
- Neonatal Death, Infectious Disease, Nutritional Deficiency
- Trial name
- VIVANT (NCT05763693)
- Testing
- Azithromycin at Baseline, Azithromycin at Day 21
- Where
- Burkina Faso
- Volunteers
- 4,000 people
- Sponsor
- University of California, San Francisco
Polycystic Ovary Syndrome, Vitamin D Deficiency
Association of Vitamin D Status With Metabolic Markers in Adolescents With Polycystic Ovary Syndrome
This prospective cross-sectional case-control study aims to investigate the relationship between serum vitamin D levels, visceral adipose tissue (VAT) thickness, and metabolic parameters in adolescents diagnosed with polycystic…
- Conditions
- Polycystic Ovary Syndrome, Vitamin D Deficiency, Insulin Resistance
- Trial name
- NCT06970821
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome
Telemedicine vs. Face-to-Face Cancer Genetic Counseling
Cancer genetic counseling (CGC) has been found to have "substantial" benefits for individuals with breast cancer and their family members; it has been deemed by multiple organizations as "standard of care" for women with breast…
- Trial name
- NCT00609505
- Testing
- Telemedicine, Face-to-Face
- Where
- 4 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Duke University
Preterm Birth, Pediatric Cancer
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
The overall aim is twofold: 1) to stretch the borderline regarding the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for facilitating and supporting self-management in families with long-term…
- Conditions
- Preterm Birth, Pediatric Cancer, Hirschsprung Disease, Congenital Malformation
- Trial name
- eChildHealth (NCT04150120)
- Testing
- e-health device with application, Mobile phone text messaging, early detection of cerebral palsy using a mobile phone application
- Where
- 7 sites in Denmark, Ethiopia and 1 more
- Volunteers
- 720 people
- Sponsor
- Lund University
Gestational Weight Gain, Diet, Food, and Nutrition
Nutri-CAP: Nutrition for Children, Adolescent Girls, and Pregnant Women in Slums of Dhaka City
The objective of the research project is to establish an evidence-based sustainable nutrition service delivery platform for optimizing pregnancy weight gain, increasing dietary diversity of adolescent girls, and ensuring proper…
- Conditions
- Gestational Weight Gain, Diet, Food, and Nutrition, Undernutrition, Health Behavior
- Trial name
- NCT05311436
- Testing
- Experimental - Intensive nutrition counselling for pregnant, adolescent and under2 children
- Where
- Bangladesh
- Volunteers
- 3,278 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Chronic Kidney Diseases, Deficiency, Vitamin D
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease
This study investigates the effect of vitamin D deficiency on drug metabolism and transport in patients with chronic kidney disease (CKD) and in healthy controls.
- Trial name
- NCT02360644
- Testing
- Cholecalciferol
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vitamin D Deficiency, Nephrolithiasis
The Effect of Vitamin D on Urinary Calcium Excretion in Kidney Stone Formers With High Urinary Calcium
The investigators hypothesize that a 3 month course of vitamin D supplementation to treat 25(OH)D deficiency in stone formers with high levels of 24-hour urinary calcium will not increase urinary calcium excretion by greater than…
- Trial name
- NCT00948740
- Testing
- vitamin D (ergocalciferol)
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Iodine Deficiency, Thyroid
Iodine Impact on Thyroid Function and Psychomotor Development, Observational Study in the Portuguese Minho Region
Full intellectual capabilities are achieved only if crucial nutrients are present during development. Iodine deficiency is the most common cause of preventable brain harm in infants.
- Conditions
- Iodine Deficiency, Thyroid, Pregnancy Related, Psychomotor Impairment
- Trial name
- IodineMinho (NCT04288531)
- Testing
- Iodine supplementation
- Where
- 10 sites in Portugal
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- University of Minho
End Stage Renal Disease (ESRD)
Evaluate the Efficacy and Safety of Amino Acid (15) Peritoneal Dialysis Solution in Peritoneal Dialysis Patients with Malnutrition.
This is a multicenter, randomized, parallel controlled Phase IV clinical study to evaluate the safety and efficacy of amino acid (15) peritoneal dialysis solution in patients undergoing peritoneal dialysis with malnutrition in…
- Trial name
- NCT06597201
- Testing
- amino acid (15) peritoneal dialysis solution, glucose peritoneal dialysis solution
- Where
- 21 sites in China
- Volunteers
- 400 people
- Sponsor
- Chengdu Qingshan Likang Pharmaceutical Co., Ltd