Clinical trials: OA, open to volunteers
Knee Osteoarthritis (Knee OA)
Effects of Feldenkrais Exercises in Knee Osteoarthritis Patients
The primary objective of the study is to determine the effects of Feldenkrais Exercises on Pain, Range of Motion, and Disability in Patients with Knee osteoarthritis.
- Trial name
- NCT06875817
- Testing
- Feldenkrais exercises, Standard physical therapy interventions
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Sarcopenia in Elderly, Osteoarthritis (OA)
Impact of Pre-operative Sarcopenia on Functional Recovery After Hip Arthroplasty in Older Adults
This single-centre, exploratory study at Montpellier University Hospital will investigate whether having low muscle mass and strength before hip-replacement surgery, a condition called sarcopenia, impact the return to everyday…
- Conditions
- Sarcopenia in Elderly, Osteoarthritis (OA), Hip Fracture Surgeries
- Trial name
- HIP-REGEN (NCT07429955)
- Testing
- Total hip replacement, Blood sampling, Muscle biopsies
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
OA Knee, TKA
Comparison of Functional Recovery Between Restricted Inverse Kinematic Alignment and Adjusted Mechanical Alignment With Robotic-assisted Unilateral Total Knee Arthroplasty.
The goal of this clinical trial is to learn if restricted inverse kinematic alignment total knee arthroplasty (restricted iKA TKA) improves functional recovery compared to adjusted mechanical alignment total knee arthroplasty…
- Trial name
- NCT06835621
- Testing
- Restricted inverse kinematic alignment Total Knee Arthroplasty, Adjusted Mechanical alignment Total Knee Arthroplasty
- Where
- 2 sites in Thailand
- Volunteers
- 80 people
- Sponsor
- Thammasat University
Knee Osteoarthritis
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks.
- Trial name
- PREDICT (NCT06245109)
- Testing
- Duloxetine, Celecoxib
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Northwestern University
Osteoarthritis (OA)
Research on the Pathogenesis and Therapeutic Targets of Articular Cartilage Degeneration in Osteoarthritis
Before you are included in this study, you will undergo the following examinations to determine if you are eligible to participate: Before you are included in this study, your doctor will ask and record your medical history…
- Trial name
- NCT07796607
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yunnan University of Chinese Medicine
Osteoarthritis, Knee, Osteoarthritis, Hip
Surgical Joint Registry MBJRF
The purpose of this study is to follow the patient's short term and long term clinical outcome after undergoing joint replacement surgery.
- Trial name
- MBJRFREG (NCT03484325)
- Where
- United States
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- Memorial Bone and Joint Research Foundation
Hip Osteoarthritis
Use of Leukocyte-Rich PRP or Leukocyte-Free PRP in the Treatment of Hip Osteoarthritis
The aim of the study is to compare the efficacy up to 12 months of two different types of PRP (PRP with leukocytes vs PRP depleted of leukocytes) in the echo-guided infiltrative treatment of hip OA by including 230 patients in…
- Trial name
- PRP22-Hip (NCT05497349)
- Testing
- Leukocyte Rich- PRP injection, Leukocyte Poor- PRP injection
- Where
- Italy
- Volunteers
- 230 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis (Knee OA)
Holistic Healing for Knee Osteoarthritis
This study is a single-center, three-arm, open-label randomized controlled trial designed to compare the effectiveness of integrated care, standard medical care, and Ayurvedic care in adults with early knee osteoarthritis…
- Trial name
- HEAL-KOA (NCT07768709)
- Testing
- Trayodashang Guggulu, Ashwagandha Churna, Janubasti
- Where
- India
- Volunteers
- 300 people
- Sponsor
- All India Institute of Medical Sciences, Jodhpur
Knee Osteoarthritis
Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma
This is a prospective cohort clinical study. Due to logistic constraints at the sites of implementation, a randomized allocation will not be feasible (private clinic).
- Trial name
- OASIS-PRP (NCT06520059)
- Testing
- Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration
- Where
- 2 sites in Portugal
- Volunteers
- 50 people
- Sponsor
- Universidade do Porto
Osteoarthritis (OA) of the Knee, Total Knee Anthroplasty
Comparison of Restricted Versus Unrestricted Kinematic Alignment in 1ry TKA
Knee osteoarthritis is a growing socioeconomic burden because of the ageing and obesity. By 2030, the majority of individuals undergoing knee arthroplasty in USA will be those younger than 65 years, with up to 1 million achieved…
- Trial name
- rKA-KA-TKA (NCT06726993)
- Testing
- Total knee arthroplasty
- Volunteers
- 80 people
- Sponsor
- Assiut University
Knee Osteoarthritis
A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a Trial
A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a Trial
- Trial name
- NCT07754175
- Where
- 2 sites in South Korea
- Volunteers
- 36 people
- Sponsor
- Kang Stem Biotech Co., Ltd.
Osteoarthritis, Spinal Arthritis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for OA
This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells delivered intravenously and intraarticularly for the treatment of Osteoarthritis.
- Trial name
- NCT05147675
- Testing
- AlloRx
- Where
- 2 sites in United States, Greece
- Volunteers
- 92 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
Platelet Rich Plasma for Musculoskeletal Conditions
The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain…
- Conditions
- Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Shoulder
- Trial name
- PRP for MSK (NCT07231471)
- Testing
- Platelet Rich Plasma Injection, Platelet Rich Plasma Preparation
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Utah
Knee Osteoarthritis (OA)
Altered Joint Mechanics and Biological Response in Osteoarthritic Knees.
Osteoarthritis (OA) stands out as the most prevalent joint disease. It manifests as a progressive degradation of articular cartilage, new bone growth and often synovial tissue proliferation, resulting in pain and compromised…
- Trial name
- AMB-OK (NCT07481461)
- Testing
- Photon counting CT scanning (PCCT scanning), Magnetic resonance imaging (MRI scanning), Gait analysis
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoarthritis, Shoulder
TSA Techniques in Glenohumeral OA
Osteoarthritis (OA) of the shoulder is a disease resulting from the wearing down of cartilage over time. OA can produce pain and dysfunction at the affected joint and is a growing occurrence in an aging population.
- Trial name
- NCT02966886
- Testing
- Eccentric Reaming, Augmented Glenoid Component Implantation, Posterior Glenoid Bone Grafting
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Ketogenic Diet to Reduce Osteoarthritis Pain in MCI
Osteoarthritis and mild cognitive impairment are common conditions that share underlying biological processes related to metabolism and inflammation.
- Conditions
- Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis
- Trial name
- KDROP-MCI (NCT07417891)
- Testing
- Well-formulated ketogenic diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Hand Osteoarthritis, Erosive Osteoarthritis
A 30-month Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate in Erosive Hand OA.
In response to the high prevalence of synovitis in hand osteoarthritis (OA) and its association with pain, there\'s a compelling rationale for investigating the efficacy of MTX in managing inflammatory erosive hand OA.
- Trial name
- MERINO:2 (NCT06281184)
- Testing
- Methotrexate, Treatment as usual
- Where
- Norway
- Volunteers
- 108 people
- Sponsor
- Diakonhjemmet Hospital
Knee Osteoarthritis (Knee OA), Chronic Pain
Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis (Knee OA), Chronic Pain, Chronic Knee Pain
- Trial name
- PACE-UP (NCT07759336)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Benedict Alter
Osteoarthritis, Knee
Boosting Exercise Adherence in Knee Osteoarthritis
This project, conducted within the Department of Veterans Affairs Healthcare System (VHA), will test the effectiveness of an intervention to improve adherence to home exercise among Veterans receiving physical therapy (PT) for…
- Trial name
- BOOST-OA (NCT07219732)
- Testing
- Usual PT Care (UC), BOOST-OA
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Hip Osteoarthritis
Platelet Rich Plasma Versus Corticosteroids in Hip Osteoarthritis Pain
Prospective, single-center that may go on to being multicenter, randomized trial comparing platelet rich plasma (PRP) versus corticosteroid injection for the treatment of symptoms of Hip osteoarthritis.
- Trial name
- NCT06793982
- Testing
- Platelet Rich Plasma Joint Injection, Corticosteroid Injection
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- LifeBridge Health