Clinical trials: OA
Knee Osteoarthritis (Knee OA)
Study in Patients With Knee Osteoarthritis Treated by Embolization Using NBGM200
Study in patients with knee osteoarthritis treated by embolization using NBGM200
- Trial name
- NCT06930677
- Testing
- embolization therapy
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 72 people
- Sponsor
- Next Biomedical Co., Ltd.
Osteoarthritis
A Phase I, Prospective, Randomized, Open-label, Active-Controlled Clinical Trial for Safety Evaluation of Intra-articular Injection of RegenoGel-SP for the Treatment of Moderate to Severe Osteoarthritis
This is a Phase I, prospective, active-controlled, randomized, open-label, clinical trial designed to assess the safety and tolerability of single intra-articular injection of RegenoGel-SP for the treatment of OA.
- Trial name
- NCT02188771
- Testing
- intra-articular administration of RegenoGel-SP or hyaluronic acid (HA)
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- ProCore Ltd.
Osteoarthritis
Muscle Strengthening Device for Knee Osteoarthritis
Studies have shown that isometric strengthening helps people with osteoarthritis of the knee. Isometric strengthening is muscle-strengthening exercise without movement, in which a person applies a force against a resistant…
- Trial name
- NCT00007241
- Testing
- Isometric exercise
- Where
- 6 sites in United States
- Volunteers
- 92 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Osteoarthritis, Knee
Efficacy of AposTherapy® in Knee OA
A prospective, interventional, randomized, double-arm clinical evaluation study to examine the efficacy of AposTherapy® versus a control group, in the short-term at 6 months and in the long-term at 12 months post-treatment, with…
- Trial name
- NCT03153956
- Testing
- Calibrated AposTherapy®
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- NYU Langone Health
Osteoarthritis
52 Week, International, Multi-center, Randomized, Double-blind, Double-dummy, Parallel-group Clinical Trial to Compare Retention on Treatment, Safety, Tolerability & Efficacy of Lumiracoxib 100 mg od, Lumiracoxib 100 mg Bid & Celecoxib 200 mg od in Pts With Primary OA of Hip, Knee, Hand or Spine
This trial will compare the retention on treatment (based on the rate of patients staying on treatment for 1 year) of patients suffering from primary osteoarthritis using two different doses of lumiracoxib (100 mg od or 100 mg…
- Trial name
- NCT00145301
- Testing
- Lumiracoxib
- Where
- Germany
- Volunteers
- 3,036 people
- Sponsor
- Novartis
Osteoarthritis of the Knee
A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain
NKTR-181 is being developed as an analgesic compound for the treatment of moderate to severe chronic pain - active as a mu agonist, but with inherent molecular properties designed to provide a unique clinical profile, including…
- Trial name
- NCT01619839
- Testing
- NKTR-181
- Where
- 34 sites in United States
- Volunteers
- 296 people
- Sponsor
- Nektar Therapeutics
Chronic Pain
A Double-blind Study of Controlled Release OROS Hydromorphone Compared to Placebo in Patients With Chronic Osteoarthritis (OA) Pain
To evaluate the efficacy of OROS Hydromorphone in reducing moderate to severe chronic pain in patients with Osteoarthritis (OA) Pain
- Trial name
- NCT00631319
- Testing
- OROS hydromorphone
- Volunteers
- 343 people
- Sponsor
- Mallinckrodt
Erosive Osteo-Arthritis
Study to Evaluate the Efficacy of Adalimumab in Patients With Erosive Osteoarthritis of the Interphalangeal Finger Joints
Patients will be randomized into two groups (1/1) during one year: 40 mg adalimumab subcutaneously (sc) every other week placebo The effect on x-rays and clinical parameters will be evaluated.
- Trial name
- NCT00296894
- Testing
- Adalimumab (40 mg sc every other week)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Ghent
Knee Osteoarthritis, Joint Diseases
MONITOR-OA: Using Wearable Activity Trackers to Improve Physical Activity in Knee Osteoarthritis
Physical activity is an essential first-line treatment for patients with knee osteoarthritis (OA). However, a 2013 systematic review found only 13% met the activity recommendation of 150 minutes or more per week.
- Trial name
- NCT02315664
- Testing
- Education session, Fitbit Flex, and remote coaching by a PT, Same intervention with a 2 month delay
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of British Columbia
Ankle Osteoarthritis
A Single Intraarticular Injection of Platelet-Rich Plasma on Pain and Physical Function in Patients With Ankle OA
Platelet-rich plasma (PRP) has been reported to be an effective treatment for knee osteoarthritis (OA). The application in ankle OA has rarely been investigated.
- Trial name
- NCT04022928
- Testing
- PRP
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Osteoarthritis, Knee
Dose-escalation of Cellistem-OA in Patients With Knee Osteoarthritis
A phase I dose-escalation trial to assess safety and efficacy of allogeneic MSC based-treatment (cellistem-OA) in patients with symptomatic knee osteoarthritis
- Trial name
- CLT-OA1 (NCT03810521)
- Testing
- umbilical cord derived-mesenchymal stromal cells
- Where
- Chile
- Volunteers
- 24 people
- Sponsor
- Universidad de los Andes, Chile
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Home-Based Strategies for Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common chronic joint condition leading to pain, functional limitations, and reduced quality of life.
- Trial name
- NCT07212647
- Testing
- Home Exercise Group, Topical Therapy Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Istanbul University - Cerrahpasa
Osteoarthritis (OA)
Future Osteoarthritis Treatment - Free Open Online Course for All
The basic treatment for osteoarthritis is education and information, often provided as so-called osteoarthritis schools. These can be provided either physically at the health center or digitally.
- Trial name
- FOOTSTEP (NCT07122154)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Eva Ekvall-Hansson
Osteo Arthritis of the Knee
Hydrogel Assessment for Local Treatment of Osteoarthritis
The study aims to evaluate the safety and tolerability of one intra-articular injection of Hydrogel OA 2% for the symptomatic treatment of osteoarthritis of the knee.
- Trial name
- HALO (NCT07516457)
- Testing
- Injection of Hydrogel OA 2%
- Where
- 3 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Allegro NV/SA
Mesenchymal Stem Cells, Knee Osteoarthritis
Cell Therapy With Cellistem-OA for Symptomatic Knee Osteoarthritis
Symptomatic knee osteoarthritis is a serious public health problem in the world, it carries a high personal, social and economic impact. Currently, there are no drugs that modify the natural course of the disease.
- Conditions
- Mesenchymal Stem Cells, Knee Osteoarthritis, Cell Therapy
- Trial name
- NCT04863183
- Testing
- CELLISTEM-OA, Triamcinolone acetonide
- Volunteers
- 30 people
- Sponsor
- Fundación Oftalmológica de Santander Clínica Carlos Ardila Lulle
Osteoarthritis of the Knee
Surgery Versus No Surgery for Osteoarthritis (OA) of the Knee
The purpose of this study is to discover whether arthroscopic surgery is helpful in controlling the symptoms of osteoarthritis of the knee.
- Trial name
- MRC Knee (NCT00562822)
- Testing
- Arthroscopic surgery, Physical and medical therapy
- Where
- Canada
- Volunteers
- 188 people
- Sponsor
- University of Western Ontario, Canada
Hand Osteoarthritis
The Hand Osteoarthritis Exercise Trial
The purpose of this study is to evaluate the effect of a hand exercise intervention on function and osteoarthritis symptoms in persons with hand osteoarthritis .
- Trial name
- NCT01245842
- Testing
- Hand exercise program
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- Diakonhjemmet Hospital
Chronic Neck Pain, Chronic Low Back Pain
Group Acupuncture Therapy With Modified Yoga
Chronic pain is prevalent in the U.S., with impact on physical and psychological functioning as well as lost work productivity. Minority and lower socioeconomic populations have increased prevalence of chronic pain with less…
- Conditions
- Chronic Neck Pain, Chronic Low Back Pain, Osteoarthritis Pain
- Trial name
- GAPYOGA (NCT04296344)
- Testing
- Acupuncture Therapy Treatments, Yoga Therapy Sessions
- Where
- 3 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Osteoarthritis, Knee, Osteoarthritis
Phase 4 Study of Laybon Tab. in Knee Osteoarthritis
This Phase 4, multicenter, randomized, double-blind, active-controlled, parallel study aims to evaluate the non-inferiority of Laybon Tab. compared to Layla Tab. (PMG Pharm Co., Ltd.) in patients with knee osteoarthritis.
- Trial name
- NCT07203547
- Testing
- Layla Tab., Laybon Tab.
- Volunteers
- 172 people
- Sponsor
- Mather's Pharm. Co., Ltd.
Osteoarthritis, Pain
Study of Safety, Efficacy of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3007
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as adjunctive therapy compared with placebo in participants with signs and symptoms of osteoarthritis of the hip or knee that are…
- Trial name
- NCT02301234
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg, Celecoxib 100 mg
- Where
- 64 sites in United States, Australia and 9 more
- Volunteers
- 111 people
- Sponsor
- Janssen Research & Development, LLC