Clinical trials: OA, open to volunteers
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
- Trial name
- SHAM-PAIN (NCT06859164)
- Testing
- Genicular Artery Embolization, Lipiodol, Simple angiogram
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Knee Arthroplasty, Total, Partial Knee Arthroplasty
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery.
- Conditions
- Knee Arthroplasty, Total, Partial Knee Arthroplasty, Chronic Pain, Postoperative, Osteoarthritis (OA) of the Knee
- Trial name
- OREOS-K (NCT07895472)
- Testing
- Standard care, Multicomponent opioid reduction and pain management pathway
- Volunteers
- 170 people
- Sponsor
- McMaster University
Periarticular Block, Osteoarthritis (OA)
Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA
Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours…
- Conditions
- Periarticular Block, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Pain After Surgery
- Trial name
- NCT07430085
- Testing
- bupivacaine-meloxicam (extended release), Bupivacaine, Ketorolac
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Osteoarthritis (OA) of the Knee, Physiotherapy
Pharmacist-physiotherapist Collaborative Management for Early Knee Osteoarthritis
Osteoarthritis (OA) is a slowly progressive chronic condition that is associated with aging and is characterized as joint pain. Individuals with early-stage OA usually do not seek medical attention.
- Conditions
- Osteoarthritis (OA) of the Knee, Physiotherapy, Pharmacy
- Trial name
- PACE-OA (NCT06681142)
- Testing
- Pharmacy-Physiotherapy Intervention
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- University of Alberta
Knee Osteoarthritis (Knee OA), Chronic Pain
Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis (Knee OA), Chronic Pain, Chronic Knee Pain
- Trial name
- PACE-UP (NCT07759336)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Benedict Alter
Hip OA
Post-Market Clinical Follow-up of Intra-Articular Hyaluronic Acid in Hip Osteoarthritis
The study population consists of approximately 40 adult outpatients aged 40 years or older with symptomatic hip osteoarthritis of at least 1 year of clinical evolution, treated with intra-articular hyaluronic acid in routine…
- Trial name
- NCT07883395
- Where
- 4 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Meiji Pharma Spain S.A.
Knee OA, Sarcopenic Obesity
Whole-body Vibration Training on the Elderly With Combined Bilateral Knee Osteoarthritis
This study will aim to evaluate the effects of whole-body vibration training (WBVT) on body composition, muscle strength (hand grip strength), and physical performance [gait speed (GS), 5-time chair stand test (5CST), and short…
- Conditions
- Knee OA, Sarcopenic Obesity, Whole Body Vibration
- Trial name
- RCT (NCT07478861)
- Testing
- Whole-body vibration training
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Beni-Suef University
Lower-limb Orthoses, Osteoarthritic Knee Pain
Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal
The overall goal of this project is to establish a novel design and control paradigm for modular, partial-assist powered orthoses (exoskeletons) to enhance voluntary lower-limb motion and manage pain in broad patient populations.
- Conditions
- Lower-limb Orthoses, Osteoarthritic Knee Pain, Osteoarthritis (OA) of the Knee
- Trial name
- NCT07673328
- Testing
- Modular powered orthosis
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Knee Osteoarthritis (Knee OA)
Evaluation of the Effects of Pulsed Electromagnetic Field on Inflammatory Knee Osteoarthritis
This study will assess the efficacy of pulsed electromagnetic field therapy in patients with inflammatory knee osteoarthritis confirmed by MRI-detected effusion-synovitis.
- Trial name
- NCT07443462
- Testing
- Pulsed Electromagnetic Field (PEMF) Therapy
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthritis (OA) of the Knee
The Effect of Physical Activity on Knee Osteoarthritis, Pain and Gait
Knee osteoarthritis, a chronic musculoskeletal disease, is the most prevalent type of osteoarthritis and the leading cause of disability and major healthcare costs worldwide.
- Trial name
- NCT07649863
- Testing
- Retro walking (backwards walking) on a treadmill
- Volunteers
- 44 people
- Sponsor
- Anglia Ruskin University
Osteoarthritis (OA) of the Knee
Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-controlled Trial
This study will focus on grade I to III knee osteoarthritis by randomized controlled trials which comparing the effectiveness between placebo, autologous platelet rich plasma and autologous platelet lysate injections.
- Trial name
- NCT03734900
- Testing
- Saline injection, PRP injection, PL injection
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Knee Osteoarthritis (Knee OA)
An Implementation Science Approach to Evaluating Self-Administered Acupressure for Knee Osteoarthritis in Older-Aged Adults in the Community
This study aims to evaluate the implementation and effectiveness of a self-administered acupressure (SAA) program for knee osteoarthritis (OA) among older adults in Hong Kong community centers.
- Trial name
- NCT07329023
- Testing
- Experimental Group: Self-Administered Acupressure (SAA), Control Group: General Health Education
- Where
- Hong Kong
- Volunteers
- 368 people
- Sponsor
- The Hong Kong Polytechnic University
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Osteoarthritis (OA) of the Knee, Knee Pain Arthritis
Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis
This study involves the use of sound waves to block pain signals caused by osteoarthritis of the knee. The sound waves are tightly focused on a specific area of the nerve.
- Conditions
- Osteoarthritis (OA) of the Knee, Knee Pain Arthritis, Chronic Knee Pain
- Trial name
- NCT07178951
- Testing
- Neurotomy of the medial sensory articular branches
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- FUSMobile Inc.
Osteoarthritis (OA) of the Knee, Fear of Needles
Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?
This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence…
- Trial name
- NCT06865170
- Testing
- 25 gauge needle, 22 gauge needle, +/- Ethyl Chloride Topical Aerosol Anesthetic
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Sleep and Pain in Osteoarthritis
People with osteoarthritis and painful joints often report poor sleep, but poor sleep can also increase pain. There have been very few studies of sleep in osteoarthritis using physical measuring devices, but in other painful…
- Trial name
- NCT07821047
- Volunteers
- 73 people
- Sponsor
- University of Reading
Knee Osteoarthritis, Osteoarthritis (Knee)
Manual Arthroplasty Versus VELYS Robotic-Assisted Solution Functional Alignment Arthroplasty for Knee Osteoarthritis
The goal of this clinical trial is to learn if the VELYS Robotic-Assisted Solution (VRAS) device helps to improve outcomes from total knee replacement, when compared to regular non-robotic-assisted total knee replacement in the…
- Conditions
- Knee Osteoarthritis, Osteoarthritis (Knee), Osteo Arthritis of the Knee, Osteo Arthritis
- Trial name
- MARVEL Project (NCT07551856)
- Testing
- Robot-Assisted Functionally Aligned Total Knee Replacement, Manual Total Knee Arthroplasty
- Where
- United Kingdom
- Volunteers
- 346 people
- Sponsor
- Golden Jubilee National Hospital
Sarcopenia in Elderly, Osteoarthritis (OA)
Impact of Pre-operative Sarcopenia on Functional Recovery After Hip Arthroplasty in Older Adults
This single-centre, exploratory study at Montpellier University Hospital will investigate whether having low muscle mass and strength before hip-replacement surgery, a condition called sarcopenia, impact the return to everyday…
- Conditions
- Sarcopenia in Elderly, Osteoarthritis (OA), Hip Fracture Surgeries
- Trial name
- HIP-REGEN (NCT07429955)
- Testing
- Total hip replacement, Blood sampling, Muscle biopsies
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Knee Osteoarthritis (OA), Postoperative Pain
Effect of Adding a Biceps Femoris Short Head Block to Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is frequently associated with moderate to severe postoperative pain, which may delay mobilization, increase opioid consumption, and impair functional recovery.
- Trial name
- BiFeS-TKA (NCT07803887)
- Testing
- Ultrasound-Guided Adductor Canal Block, Ultrasound-Guided Biceps Femoris Short Head Block
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Antalya Training and Research Hospital
Osteoarthitis, Osteoarthritic Knee Pain
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee.
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- Medial OA CSI (NCT07804446)
- Testing
- Anteromedial Injection, Anterolateral Injection
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Chicago