Clinical trials: OA Knee
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Knee Chondropathy, Osteoarthritis, Knee
Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology
The investigators hypothesized that intra-articular injections of Platelet-rich Plasma (PRP) to treat knee degenerative articular cartilage pathology could determine pain relief and recovery of knee function with overall clinical…
- Trial name
- PRP2009 (NCT01670578)
- Testing
- PRP, Hyaluronic acid
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis
African American Preference for Knee Replacement: A Patient-Centered Intervention
A randomized, controlled design will be utilized to examine and compare the effectiveness of the proposed educational intervention, which includes an educational decision aid with attention control on select key patient-centered…
- Trial name
- ACTION (NCT01851785)
- Testing
- Decision Aid (DA) Intervention
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- University of Pennsylvania
Osteoarthritis of the Knee
Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee
The purpose of this study is to compare the efficacy of celecoxib versus placebo in delaying the onset of pain and improving walking function in subjects with knee Osteoarthritis
- Trial name
- NCT00597415
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Osteoarthritis of the Knee
KineSpring® System Patient Preference Study
The primary objectives of the survey are to obtain patient preference information that can be useful during the benefit-risk assessment of the KineSpring System.
- Trial name
- NCT02934672
- Testing
- Survey
- Volunteers
- 323 people
- Sponsor
- Moximed
Osteoarthritis
Health and Risk Factors in Patients With Hip and Knee Osteoarthritis
Hip and knee osteoarthritis is one of the leading causes of global disability. There is no cure for the disease, but research and guidelines recommends that patients with osteoarthritis, early after the diagnosis, receive…
- Trial name
- NCT03438630
- Where
- Sweden
- Volunteers
- 288,276 people
- Sponsor
- Vastra Gotaland Region
Osteoarthritis of Knee
Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency
This study investigates the effectiveness of two treatments-genicular nerve radiofrequency ablation and pulsed radiofrequency-in reducing pain and improving function in osteoarthritis patients.
- Trial name
- GRFT-PRF (NCT06894147)
- Testing
- Genicular nerve pulse radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, Knee
Probiotic Supplements in Osteoarthritis
The current study aims to evaluate the effectiveness of adding probiotics to the standard of care in improving OA patient-related outcomes such as pain, stiffness, and physical activity.
- Trial name
- NCT07364578
- Testing
- Probiotic Formula, Control
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- Beni-Suef University
KOA
A Study of [89Zr]-Oxine-NCR100 Injection for the Cellular Distribution
This clinical study is to evaluate the biodistribution of [89Zr]-Oxine-NCR100 injection in subjects with knee osteoarthritis after local injection and the kinetic behavior characteristics of zirconium-labeled cells at the…
- Trial name
- Distribution (NCT07139431)
- Testing
- NCR100
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Knee Osteoarthritis, Total Knee Arthroplasty
Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance
The investigators hypothesized that intraoperative opioid consumption would be different between remimazolam and propofol if the ANI-guided remifentanil continuous infusion rate was adjusted when the depth of anesthesia was…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Remimazolam
- Trial name
- NCT05322902
- Testing
- remimazolam group, propofol group
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Gangnam Severance Hospital
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
Balneotherapy With Acquabios Thermal Water in Knee Osteoarthritis
The aim of the study is the evaluation of the effect of balneotherapy with Acquabios bicarbonate-alkaline-sodium thermal water in ameliorating some signs and symptoms of knee osteoarthritis in human subjects suffering from this…
- Trial name
- NCT05352477
- Testing
- Balneotherapy with thermal water, Balneotherapy with tap water
- Volunteers
- 88 people
- Sponsor
- University of Roma La Sapienza
Pain, Osteoarthritis, Hip
Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee
This clinical trial tests the pain relieving effectiveness of OROS hydromorphone, a once-daily formulation of a strong opioid against placebo in patients, who are suffering from pain due to osteoarthritis of the hip or the knee…
- Conditions
- Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT00980798
- Testing
- OROS hydromorphone HCl
- Where
- 12 sites in Czechia, Romania and 2 more
- Volunteers
- 288 people
- Sponsor
- Janssen-Cilag International NV
Knee Osteoarthritis
The Efficacy of Exercise and Alternative Applications of NMES on Pain and Function in Patients With Knee OA
The aim of the study was to investigate the efficacy of exercise and different size electrodes of neuromuscular electrical stimulation (NMES) applications on pain, range of motion (ROM), muscle strength, function status and…
- Trial name
- NCT03571698
- Testing
- Neuromuscular Electrical Stimulator
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Degenerative Arthritis, Knee Arthritis
Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy
This clinical trial is conducted to assess the long-term safety of "jointstem" in patients with degenerative knee arthritis who participated in the previous BS-JS-IIT1 investigator initiated trial.
- Trial name
- NCT04825730
- Testing
- JOINTSTEM
- Volunteers
- 14 people
- Sponsor
- R-Bio
Knee Osteoarthritis
Dietary Supplementation With Blueberry in OA
Osteoarthritis is a painful long term joint condition that is associated with poor quality of life. There are no treatments to prevent it. Inflammation is one cause of osteoarthritis. This inflammation is complex.
- Trial name
- NCT05784545
- Testing
- Blueberry powder supplement, Maltodextrin supplementation
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University of Exeter
Osteoarthritis, Knee
Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis
In this, prospective, double-blind study, patients with mild to moderate symptomatic knee osteoarthritis will be randomized to receive either a series of leukocyte poor, platelet-rich plasma or hyaluronic acid injections under…
- Trial name
- HA vs PRP (NCT02588872)
- Testing
- Platelet-rich Plasma (PRP), Hyaluronic Acid
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis (OA)
Clinical Study on the Combination of Xiaoyu Zhitong Formula and Lymphatic Drainage Technique to Improve the Symptoms of Knee Pain and Swelling in Cold Dampness Obstruction Type
This research project applies a combination of blood stasis relieving and pain relieving formula and lymphatic drainage technique to treat patients with cold dampness obstruction type knee joint pain.
- Trial name
- NCT06911437
- Testing
- treatment group, control group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- tang jie
Osteoarthritis, Knee
The Effect of Therapeutic Methods for Chronic Knee Osteoarthritis Pain
Chronic osteoarthritis (OA) pain of the knee is not effectively abrogated by the available non-pharmacologic or pharmacologic treatments. Radiofrequency (RF) neurotomy is a therapeutic alternative for chronic pain.
- Trial name
- NCT00924677
- Testing
- radiofrequency neurotomy for genicular nerve
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center