Clinical trials: OCD
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Obsessive-Compulsive Disorder (OCD)
Explore Neural Mechanism of Obsessive-Compulsive Disorder (OCD) by Intervention of Repetitive Transcranial Magnetic Stimulation With Symptom Provocation
The purpose of this study is to investigate the differences in therapeutic efficacy of different deep Transcranial Magnetic Stimulation (deep TMS) treatment coils and different brain stimulation targets on obsessive-compulsive…
- Trial name
- NCT07587112
- Where
- Taiwan
- Volunteers
- 96 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
OCD, Obsessive-Compulsive Disorder
Locating Biomarkers in OCD Through Behavioral Tasks
Subjects that have a diagnosis of OCD will participate in a clinical interview and cognitive tasks, during which they will be exposed to their individual OC stressors or will be asked to make decisions related to information…
- Trial name
- NCT03313622
- Testing
- Beads Task, PROVOC Tasks
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Obsessive Compulsive Disorder (OCD)
Connectomic Deep Brain Stimulation for Obsessive Compulsive Disorder
Deep brain stimulation (DBS) is an effective treatment for people suffering from severe obsessive-compulsive disorder (OCD) whose symptoms have failed to improve after years and multiple methods of intervention.
- Trial name
- NCT05160129
- Testing
- Selective focal stimulation of ALIC-pathways
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Obsessive-Compulsive Disorder (OCD)
Comparing Exposure v Imagery Rescripting in People With OCD: a SCED
Individuals with OCD may experience intrusive future orientated thoughts and images, which are extremely distressing and interfering in life.
- Trial name
- NCT06944366
- Testing
- Imagery intervention
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- King's College London
Obsessive Compulsive Disorder (OCD), Comorbid Post-Traumatic Stress Disorder and OCD
ERP to Improve Functioning in Veterans With OCD
Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no…
- Trial name
- NCT05240924
- Testing
- Exposure and Response Prevention, Stress Management Training
- Where
- 19 sites in United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Obsessive-Compulsive Disorder, OCD
Personalized DBS for OCD Guided by Stereoencephalography Mapping
This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months.
- Trial name
- NCT06347978
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Andrew Moses Lee, MD, PhD
OCD, Obsessive - Compulsive Disorder
Effect of Emotion-Focused Acceptance and Commitment Therapy on Obsessive-Compulsive Disorder Symptom Severity
This study aims to investigate the effect of Emotion-Focused Acceptance and Commitment Therapy (ACT) group psychotherapy on obsessive-compulsive disorder (OCD) symptom severity.
- Trial name
- ACT-OCD (NCT07622654)
- Testing
- Emotion-Focused Acceptance and Commitment Therapy (ACT) Group Psychotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Mehmet Emrah Karadere
Obsessive Compulsive Disorder (OCD), Lifestyle (Sedentary Behavior and Physical Activity)
A Lifestyle Intervention to Reduce Cardiometabolic Risk Factors in Individuals With Obsessive-compulsive Disorder
The overall aim of this study is to evaluate the efficacy and cost-effectiveness of a lifestyle intervention to improve lifestyle habits and reduce cardiometabolic risk factors in individuals with obsessive-compulsive disorder…
- Trial name
- LIFT (NCT07206212)
- Testing
- A group-based lifestyle intervention for individuals with OCD, Medical and lifestyle advice
- Where
- Sweden
- Volunteers
- 108 people
- Sponsor
- Karolinska Institutet
Depression, OCD
Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
The study involves multiple retrospective analyses to understand the utilization of mental health treatments provided at Greenbrook and their effectiveness
- Conditions
- Depression, OCD, Anxiety Depression
- Trial name
- NCT06997549
- Testing
- Patients treated with NeuroStar TMS, Patients treated with Esketamine
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- Neuronetics
Obsessive Compulsive Disorder (OCD)
iCBT for Adolescents Obsessive-compulsive Dissorder
The goal of the study is to assess the feasibility, acceptability, and potential effects of therapist-guided internet-delivered cognitive-behavior therapy (iCBT) for adolescent obsessive-compulsive disorder, using a recently…
- Trial name
- NCT07469358
- Testing
- Behavioral: icbt.
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Clinic of Barcelona
Transdiagnostic, Depression - Major Depressive Disorder
Open-Label Psilocybin Study in Transdiagnostic Population
The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms.
- Conditions
- Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms
- Trial name
- NCT06442423
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Obsessive-Compulsive Disorder (OCD)
The Efficacy of Temporal Interference Stimulation in the Treatment of Obsessive-Compulsive Disorder
This study aims to evaluate the efficacy of Temporal Interference (TI) stimulation in treating patients with obsessive-compulsive disorder (OCD) and to explore its potential neural mechanisms using magnetic resonance imaging…
- Trial name
- NCT07113652
- Testing
- TI stimulation device (nerviox-1000）
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center
Emotion Regulation, Mood Disorders
Neurostimulation Versus Therapy for Problems With Emotions
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation…
- Conditions
- Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders
- Trial name
- NCT05712057
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), electrical scalp stimulation, Cognitive Restructuring
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Duke University
Obsessive Compulsive Disorder (OCD)
Priming CBT With rTMS for OCD
Cognitive behavioural therapy (CBT), incorporating exposure/response prevention (ERP) and cognitive therapy, is considered the gold-standard first-line treatment for obsessive-compulsive disorder (OCD).
- Trial name
- NCT06840951
- Testing
- rTMS, CBT
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD)
Stepped Care Treatment for Anxiety Resilience
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD.
- Conditions
- Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD), Separation Anxiety Disorder, Specific Phobia
- Trial name
- STAR (NCT07228143)
- Testing
- Relaxation and Mentorship Training (RMT), Stepped Care Targeting Exposure and Parenting for Anxiety (STEP-A)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Andrew Wiese
Osteochondritis Dissecans Knee, Osteochondritis Dissecans (OCD)
Treatment Outcomes for Osteochondritis Dissecans of the Knee: A Cohort Study
This is a non-randomized, observational, ambidirectional cohort study. Approximately 254 participants with knee OCD will be recruited from Peking University Third Hospital, China, comprising a prospective cohort (n=177) and a…
- Trial name
- NCT07439107
- Testing
- Clinical Management for OCD (Observed)
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Peking University Third Hospital
Depression Disorders, Bipolar Affective Disorder
Epidemiological Study on the Prevalence of Mental Disorders in Slovakia
This study maps the current epidemiological situation of mental disorders in Slovakia. The aim of the study is to determine the prevalence of selected mental disorders in the adult population of the Slovak Republic, assess the…
- Conditions
- Depression Disorders, Bipolar Affective Disorder, Generalized Anxiety Disorder (GAD), Panic Disorder
- Trial name
- EpiMentDisSK (NCT07129408)
- Where
- Slovakia
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- Comenius University