Clinical trials: OCTA, open to volunteers
Central Serous Chorioretinopathy (CSC)
Prospective Geometric Analysis of Ultra-Widefield OCTA Characteristics in Central Serous Chorioretinopathy Patients
By leveraging parameters including fractal dimension and topological index, we constructed a quantitative evaluation framework for ultra-widefield optical coherence tomography angiography (UWF-OCTA) images in patients with…
- Trial name
- NCT07347119
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Retina Disease, Glaucoma
Multi-modal Intelligent Diagnosis System for Multiple Ophthalmic Diseases
Aiming at the problems of low image reading efficiency, crowded medical resources and fragmented cross-modal information of ophthalmic OCT and OCTA, a multimodal large model diagnostic framework for various diseases such as…
- Trial name
- NCT07143851
- Testing
- Not applicable- observational study
- Volunteers
- 5,000 people
- Sponsor
- Beijing Hospital
Patients With Cardiovascular Disease, Healthy Participants
OCTA in Cardiovascular Disease and Healthy Controls
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy…
- Trial name
- NCT07359664
- Testing
- Retinal vascular assessment using OCTA and SLDF
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Age - Related Macular Degeneration (AMD)
Effect of Fu's Subcutaneous Needling for Age-related Macular Degeneration
This pilot randomized controlled trial aims to evaluate the efficacy and safety of FSN in improving symptoms in patients with dAMD.38 eligible participants will be recruited and randomly assign them in a 1:1 ratio to the FSN…
- Trial name
- NCT07121127
- Testing
- FSN+Vitamin supplement, Vitamin Supplements
- Volunteers
- 38 people
- Sponsor
- Zhiming Yan
Age - Related Macular Degeneration (AMD), Diabetic Macular Edema
Wide Field OCTA in Ocular Diseases
The main retinal diseases, whether or not associated with specific mutations genetic, cause progressive degeneration of vascular retinal structures and not vascular, resulting in decreased visual function.
- Conditions
- Age - Related Macular Degeneration (AMD), Diabetic Macular Edema, Diabetic Retinopathy, Myopia
- Trial name
- WOOD-2025 (NCT07298174)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Neovascular Glaucoma, Type 2 Diabetes
Observation of Iris Blood Flow Via OCTA in Diabetic Neovascular Glaucoma
The goal of this observational study is to quantify iris blood flow via non-invasive eye scanning for evaluating ocular lesions in adults aged 18 years and older, including healthy volunteers, patients with type 2 diabetes…
- Trial name
- NCT07722910
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Qilu Hospital of Shandong University
Glaucoma, OCTA
Choroidal and Retinal Features in PACD and POAG on OCT and OCTA
Glaucoma is a group of irreversible, progressive optic neuropathies that can lead to severe visual field defects and even blindness, affecting nearly 95 million people worldwide.
- Conditions
- Glaucoma, OCTA, Choroid
- Trial name
- NCT07580014
- Where
- China
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Preeclampsia (PE), Hypertension ,Pregnancy
Retinal and Choroidal Microcirculation in Preeclampsia: An OCTA Study
Preeclampsia is a multisystemic and multifactorial disorder that complicates pregnancy and is characterized by new-onset hypertension after the 20th week of gestation accompanied by proteinuria or systemic findings such as renal…
- Conditions
- Preeclampsia (PE), Hypertension ,Pregnancy, Retinal Microvascular Changes, Hypertensive Disorders of Pregnancy
- Trial name
- PE-OCTA (NCT07874191)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Diabetic Retinopathy
Assessment of Retinal Microvascular Changes by OCT Angiography in Diabetic Retinopathy
This observational cross-sectional study aims to assess retinal microvascular changes using optical coherence tomography angiography (OCTA) in patients with diabetic retinopathy.
- Trial name
- NCT07747428
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Hypertension, Diabetes Mellitus
Retinal Vascular Manifestations in Patients With Common Internal Diseases on OCTA Tomography Angiography
Hypertension, diabetes mellitus, and dyslipidemia are common internal diseases, and all diseases are atherosclerosis risk factors.
- Conditions
- Hypertension, Diabetes Mellitus, Dyslipidemias
- Trial name
- NCT05644548
- Testing
- No intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tongren Hospital
OCTA, Severe Brain Injury
Effect of the Stellate Ganglion Block on the Retinal Microcirculation
Surges in the sympathetic nervous system occur at the ictus of a variety of neurological critical illnesses including intracranial hemorrhage and ischemic stroke.
- Conditions
- OCTA, Severe Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- NCT06797752
- Testing
- OCTA Scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
GPA, Vasculitis
Ocular Manifestations of Granulomatosis With Polyangiitis.
The current state of knowledge on ANCA-associated vasculitis (AAV) indicates that it is a group of autoimmune diseases in which small blood vessels in various organs are affected.
- Conditions
- GPA, Vasculitis, Microscopic Polyangiitis (MPA), Churg-Strauss Syndrome (CSS)
- Trial name
- NCT07664709
- Testing
- Optical coherence tomography angiography
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Military Institute od Medicine National Research Institute
Retinopathy of Prematurity
Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)
Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime.
- Trial name
- BabySTEPS2 (NCT04995341)
- Testing
- Investigational ultracompact OCT and OCTA system, retinal photographs
- Where
- 2 sites in United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Duke University
Amblyopia, VEP
Possible Beneficial Effects Of Combined Fluoxetine And Occlusion Therapy In Improving And Maintaining Vision In Amblyopia Using Optical Coherence Tomography Angiography (OCTA) And Visual Evoked Potential (VEP). The Aim Of The Study Is To Evaluate Possible Beneficial Effects For Different Age Groups.
Amblyopia is described as a limitation of the visual function of one or both eyes with no pathological cause, with a prevalence of about 1-5% of the total world population.
- Trial name
- VA; OCTA; VEP; (NCT07417046)
- Testing
- Flouxetine, Patching therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Myopic Choroidal Neovascularization
Deep Learning-Based OCTA Quantification and Modeling for Predicting Long-Term Anti-VEGF Efficacy in mCNV
Myopic choroidal neovascularization (mCNV) is one of the sight-threatening complications secondary to pathological myopia. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) is its first-line therapy.
- Trial name
- NCT07402629
- Testing
- No interventions beyond routine medical care
- Volunteers
- 110 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetic Retinopathy
Investigating the Retardation Effect of OCTA-Guided Targeted Photocoagulation on the Progression of Non-Perfusion Areas in Diabetic Retinopathy Patients
This study aims to evaluate the impact of widefield OCTA-guided selective photocoagulation on the progression of diabetic retinopathy (DR) by comparing the control of non-perfusion (NP) areas, DR grading, and management of other…
- Trial name
- NCT06821633
- Testing
- Targeted laser photocoagulation guided by OCTA (Optical Coherence Tomography Angiography)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sichuan Provincial People's Hospital
Coronary Microvascular Disease
A Clinical Study of Fundus OCTA for the Identification of CMD
Coronary microvascular dysfunction (CMD) carries an increased risk of adverse cardiovascular clinical outcomes. The association between fundus microcirculation changes and coronary microcirculation is not well understood.
- Trial name
- NCT05743140
- Testing
- CaIMR
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University First Hospital
Multiple Sclerosis
Oct-A and Perimetry in Multiple Sclerosis
This study aims to assess retinal vascular density using OCT-A and correlate these parameters with visual field changes in MS patients with and without a history of ON
- Trial name
- MS (NCT07175324)
- Testing
- optical coherence tomography angiography, Visual Field Perimetry
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Assiut University
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
MINOCA, STEMI
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS…
- Conditions
- MINOCA, STEMI, Normal
- Trial name
- REVEAL (NCT07055152)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Pisa