Clinical trials: OHS
Obesity Hypoventilation Syndrome (OHS)
Pathophysiology of Hypoventilation in Obesity and Effects of Bariatric Intervention
Breathing is impacted by obesity. Early changes are characterised by significant breathing abnormalities during sleep (a condition called sleep disordered breathing, the most common of which is obstructive sleep apnoea).
- Trial name
- PHOEBI (NCT04025528)
- Testing
- Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obesity Hypoventilation Syndrome (OHS), Obstructive Sleep Apnea (OSA)
Transdisciplinary Intervention for Obesity Hypoventilation Syndrome
The aims of this prospective observational cohort study are threefold: (1) to assess the prevalence of obesity hypoventilation syndrome (OHS) in individuals with obesity and obstructive sleep apnea (OSA) and identify associated…
- Trial name
- CABS for OHS (NCT07020689)
- Testing
- CABS
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Obesity Hypoventilation Syndrome (OHS)
Obesity in Sleep Medicine - Focusing on OHS Phenotypes
This study focuses on a comprehensive examination of obese patients with sleep-related breathing disorders including patients with OSA, sleep hypoventilation and OHS.
- Trial name
- NCT04570540
- Testing
- Sleep Study, Pulmonary Function Test, Hypercapnic ventilatory response
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Obesity Hypoventilation Syndrome (OHS)
Evaluation of Upper Extremity Functions in Obesity Hypoventilation Syndrome Patients
Obesity Hypoventilation Syndrome (OHS) is a disease characterized by daytime hypercapnia and sleep-related respiratory disturbances in individuals with a body mass index (BMI) greater than 30 kg/m², without any other condition…
- Trial name
- NCT06766110
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Istanbul University - Cerrahpasa
Obesity-hypoventilation Syndrome, Nocturnal Alveolar Hypoventilation
Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -
Investigate whether the course of an isolated nocturnal alveolar hypoventilation can predict the future occurrence of obesity-hypoventilation syndrome (OHS) in obese subjects
- Trial name
- NCT02021448
- Testing
- Annual visits among 3 years. During each visit different testings are performed in order to detect an obesity-hypoventilation syndrome (OHS)
- Where
- 6 sites in France
- Volunteers
- 188 people
- Sponsor
- University Hospital, Strasbourg, France
Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Lung Disease
Telemedical Assistance in Automatic Titration of Oxygen for Intensive Care Patients
The goal of this clinical trial is to clinically validate a system for the monitoring of patients' respiratory function and automated oxygen treatment proposal using non-invasive ventilation devices in the treatment of intensive…
- Conditions
- Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Lung Disease, Interstitial Lung Disease, Pneumonia
- Trial name
- Smartassistant (NCT06090149)
- Testing
- PHASE 1 Lowenstein medical BiLevel Prisma 25ST device: withount oxygen support., PHASE 2. Continous/Bilevel positive airway presure with additional oxygen support by Devilbiss 525 KS oxygen concentrator
- Where
- Latvia
- Volunteers
- 30 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Obesity-Hypoventilation Syndrome (OHS)
Use of Polysomnography for Non-Invasive Ventilation Settings' Optimization
The aim of this randomized controlled trial is comparing the improvement of diurnal PaCO2 in OHS patients after one month of NIV treatment depending upon the tools used for adjusting settings.
- Trial name
- NIV-OHS (NCT00603096)
- Testing
- GoodKnight 425ST - Mallinckrodt DF, Tyco Healthcare
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Tyco Healthcare Group
Obesity Hypoventilation Syndrome (OHS), Hypoventilation
Effects of Exercise Training on Exercise Capacity and Sleep Quality in Patients With Obesity Hypoventilation Syndrome
Obesity Hypoventilation Syndrome is defined as a combination of obesity (BMI ≥ 30 kg/m2) and daytime hypercapnia in arterial blood gas analysis (PaCO2 > 45 mmHg) without other pathologies that cause hypoventilation.
- Conditions
- Obesity Hypoventilation Syndrome (OHS), Hypoventilation, Obesity, Respiration Disorders
- Trial name
- NCT05398068
- Testing
- Exercises and Diet, Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Respiratory Failure Chronic, Obesity Hypoventilation Syndrome
Myocardial Effects of NIV in OHS Patients
Chronic effects of noninvasive ventilation on myocardial function in patients with obesity hypoventilation syndrome (OHS) are scarcely understood.
- Conditions
- Respiratory Failure Chronic, Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea, Cardiac Output, Low
- Trial name
- NCT06486129
- Testing
- Noninvasive ventilation volume targetted
- Where
- Slovakia
- Volunteers
- 13 people
- Sponsor
- Pavol Jozef Safarik University
Systemic Lupus Erythematosus (SLE), Refractory
Clinical Trial of CD19 Targeted CAR-T Cell in Refractory Adult SLE
This is a single-arm, open, dose-increasing and dose-expanding phase I clinical trial to investigate the safety, tolerability and cytodynamic characteristics of MC-1-50 cell preparation, and to preliminatively observe the…
- Trial name
- NCT06892145
- Testing
- MC-1-50
- Where
- 2 sites in China
- Volunteers
- 12 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Ocular Histoplasmosis Syndrome
Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome
The purpose of this study is to evaluate the safety and effectiveness of intravitreal ranibizumab (Lucentis) in patients with fluid and blood leakage in their eyes due to ocular histoplasmosis.
- Trial name
- IVL for OHS (NCT00955630)
- Testing
- ranibizumab
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Retina Associates of Kentucky
Obesity Hypoventilation Syndrome (OHS)
Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome
It remains unclear whether CPAP therapy should be prescribed if significant hypoxemia persists during CPAP titration, despite optimization of upper airway obstructive events, if maximum CPAP pressure is reached.
- Trial name
- AVAPS (NCT06442163)
- Testing
- AVAPS study was performed within 1 week of the CPAP titration attempt failure, using the auto-titrating EPAP (AE), the OmniLab Advanced +, System One device (Philips Respironics, Murrysville, PA, U.S.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Acute on Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome (OHS)
"Post-acute Pickwick Study" (Postacute-Pick-2020)
We propose to carry out a large multicentric, multinational, randomized controlled trial with two phases (two sequential randomized controled trials) to answer two questions: 1) Should hospitalized patients with recently…
- Trial name
- NCT04317326
- Testing
- "Lifestyle modifications" group (Control), Automatic NIV, CPAP treatment group
- Sponsor
- Juan F. Masa
Obesity Hypoventilation Syndrome (OHS)
Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity [body mass index (BMI) ≥30 kg/m2], chronic daytime hypercapnia (PaCO2 >45 mm Hg), and sleep-apnea in the absence of other known causes of hypercapnia.
- Trial name
- NCT04835558
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University