Clinical trials: OSAHS
Obstructive Sleep Apnea
A Phase II Pilot Study of the Trillium Full Face Mask
This will be a single-center, open-label randomized crossover design pilot study to evaluate the clinical safety, clinical performance, and clinical benefit of the Trillium full face mask
- Trial name
- NCT06932055
- Testing
- Trillium Full Face Mask, AirFit F20
- Volunteers
- 40 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Atrial Fibrillation, Arrhythmia
Arrhythmia Detection In Obstructive Sleep Apnea (ADIOS)
The purpose of this research study is to learn about arrhythmia detection in obstructive sleep apnea (OSA). For several years patients with OSA have an increased likelihood of having irregular heartbeats.
- Conditions
- Atrial Fibrillation, Arrhythmia, Stroke, Cardiovascular
- Trial name
- ADIOS (NCT02743520)
- Testing
- The Lifestar Act III
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Miami
Obstructive Sleep Apnea
Mechanisms of Upper Airway Obstruction
The current study is designed to examine underlying mechanisms of action of lingual muscles in the maintenance of airway patency during sleep.
- Trial name
- DISE-CAD (NCT04322097)
- Testing
- Hypoglossal Nerve Stimulation
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea
Pilairo Lab Market Research
The purpose of the study is to observe the Pilairo mask in a lab setting.
- Trial name
- NCT01824979
- Testing
- CPAP mask ( Pilairo), Other CPAP mask
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Simulated In-House Usability Study of Eclipse Continuous Positive Airway Pressure (CPAP) Device
The study is designed to assess the usability of a novel CPAP human interface compared to a traditional nasal mask. Human subjects will interact with two different CPAP interfaces including a traditional CPAP mask and the 2nd…
- Trial name
- NCT05570747
- Testing
- Usability
- Where
- 3 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bleep, LLC
Sleep Apnea, Obstructive, Primary Open-angle Glaucoma
IOP Fluctuations in Patients With Sleep Apnea With or Without Primary Open Angle Glaucoma Using Positive Airway Pressure
Sleep apnea is characterized by repetitive episodes of decreased or interrupted airflow in the upper airways during sleep. Obstructive sleep apnea syndrome (OSAS) is the most common sleep-related breathing disorder and is…
- Trial name
- NCT01560975
- Testing
- SENSIMED Triggerfish®
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sensimed AG
Obstructive Sleep Apnea-hypopnea Syndrome
Effects of Myofunctional Therapy With an Application in Severe Apnea/Hypopnea Sleep Obstructive Syndrome (MTASSAOS)
Background and study aims: Obstructive sleep apnea is a potentially serious sleep disorder. It causes breathing to stop and start repeatedly during sleep.
- Trial name
- MTASSAOS (NCT04438785)
- Testing
- The intervention consists of myofunctional therapy (MT) using the AirwayGym app.
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Quironsalud
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea
This trial is conducted in North America. The aim of the trial is to investigate the effect of liraglutide in obese subjects with sleep apnoea.
- Conditions
- Metabolism and Nutrition Disorder, Obesity, Obstructive Sleep Apnoea
- Trial name
- NCT01557166
- Testing
- liraglutide
- Where
- 42 sites in United States, Canada
- Volunteers
- 359 people
- Sponsor
- Novo Nordisk A/S
Obstructive Sleep Apnea
Comparative Effectiveness Research to Enhance Outcomes in African-Americans With Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is under-diagnosed and is associated with increased cardiovascular morbidity and mortality. Laboratory-based overnight polysomnography (PSG) is the gold standard in clinical practice to diagnose OSA…
- Trial name
- NCT01997723
- Testing
- Portable monitoring, Polysomnography, Home portable monitoring
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Illinois at Chicago
Sleep Apnea
Oxytocin on HR in Sleep Apnea Patient
In human volunteers intranasal administration of oxytocin significantly increases parasympathetic and decreases sympathetic cardiac control.
- Trial name
- NCT02564068
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- George Washington University
Down Syndrome, Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
Many individuals with Down syndrome (DS) have breathing problems during sleep. This is called obstructive sleep apnea syndrome (OSAS).
- Trial name
- TRIO (NCT01808508)
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospital of Philadelphia
Obstructive Sleep Apnea
Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic
Patients who have obstructive sleep apnea (OSA) frequently stop breathing while they sleep. They often develop high blood pressure. We are not sure what drug is best to treat the high blood pressure.
- Trial name
- guanhctz (NCT02699125)
- Testing
- Guanfacine, Hydrochlorothiazide
- Volunteers
- 41 people
- Sponsor
- University of California, San Diego
OSA - Obstructive Sleep Apnea
Parallel Arm Trial of AD109 and AD504 In Patients With OSA
This is a phase 2 randomized double-blind placebo-controlled parallel-arm dose finding study to compare fixed dose combinations of AD109 and AD504 to atomoxetine or placebo in Obstructive Sleep Apnea.
- Trial name
- MARIPOSA (NCT05071612)
- Testing
- AD109, AD504, Atomoxetine Hydrochloride
- Where
- 25 sites in United States
- Volunteers
- 294 people
- Sponsor
- Apnimed
Sleep Apnea, Obstructive
Auto Continuous Positive Airway Pressure (CPAP) Based Energy Spectrum Analysis of Flow for Treatment of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
Nasal Continuous Positive Airway Pressure (CPAP) is the standard therapy for obstructive sleep apnea hypopnea syndrome (OSAHS). This is most commonly administered as a single positive pressure that has been individualized for the…
- Trial name
- NCT00750165
- Testing
- SleepStyle 200 Auto Series CPAP Humidifier
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Fisher and Paykel Healthcare
Stroke, Obstructive Sleep Apnea
Burden of Obstructive Sleep Apnea in Stroke (BOSAST)
There are two purposes of this study. The first purpose is to define the frequency of obstructive sleep apnea in stroke survivors as well as its association with fatigue and quality of life.
- Trial name
- BOSAST (NCT00952211)
- Testing
- CPAP, CPAP at sub-therapeutic pressure
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea (OSA)
Atomoxetine and Oxybutynin in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- ATOSA (NCT02908529)
- Testing
- Combination product of Atomoxetine and Oxybutynin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Brigham and Women's Hospital
Lung Disease
DREAM: Does Inhaled Fluticasone REsult in Obstructive Sleep Apnea Manifestations?
This study is being conducted to find out if the use of inhaled corticosteroids has an affect on upper airway (UAW) collapsibility and sleep apnea risk.
- Trial name
- DREAM (NCT01184118)
- Testing
- FP 220 mcg 2 puffs BID
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Wisconsin, Madison
Sleep Apnea
Addressing Insufficient PAP Use in Older Veterans
Obstructive sleep apnea (OSA) is a common problem among middle-aged and older Veterans that is associated with poor nighttime sleep, more daytime sleepiness, poor functioning and worse quality of life.
- Trial name
- NCT04868682
- Testing
- PAP Adherence Program, Active Control
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- VA Office of Research and Development
Obesity, Sleep Apnea, Obstructive
Pragmatic Obstructive Sleep Apnea Weight Loss Trial Assessing Effectiveness and Reach
Prevalent obesity related conditions like obstructive sleep apnea (OSA) represent an important opportunity to improve population health. OSA reduces quality of life and is associated with greater risk for cardiovascular disease.
- Trial name
- POWER (NCT05104450)
- Testing
- lifestyle intervention
- Where
- United States
- Volunteers
- 696 people
- Sponsor
- VA Office of Research and Development
Sleep Disordered Breathing, Sleep Hypopnea
Apnea Hypopnea Index Severity Versus Head Position During Sleep
This study evaluates the correlation of the position of the head during sleep, independent of the position of the torso, and the severity of apnea hypopneas in obstructive sleep apnea.
- Conditions
- Sleep Disordered Breathing, Sleep Hypopnea, Sleep Apnea, Sleep Apnea, Obstructive
- Trial name
- NCT04086407
- Testing
- Dual-axis inclinometer attached to the subject's forehead with tape
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Sleep Systems