Clinical trials: OSAS
Obstructive Sleep Apnea, Morbid Obesity
Epigenetics Modifications in Morbid Obesity and Obstructive Sleep Apnea Patients: The EPIMOOSA Study
This study evaluates epigenetics in morbid obese patients who are waiting for bariatric surgery. A home cardiopulmonary polygraphy is performed to evaluate for the presence of sleep-disordered breathing.
- Conditions
- Obstructive Sleep Apnea, Morbid Obesity, Epigenetic Disorder
- Trial name
- EPIMOOSA (NCT03995836)
- Testing
- CPAP, Bariatric Surgery
- Volunteers
- 70 people
- Sponsor
- Aragon Institute of Health Sciences
Obstructive Sleep Apnea Syndrome
Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children
The aim of the project is to evaluate whether therapy with leukotriene may be a valid therapeutic approach in children with adenotonsillar hypertrophy and with mild and moderate obstructive sleep apnea syndrome (OSAS) and to…
- Trial name
- SB-OSAS (NCT00912171)
- Testing
- budesonide (Aircort 50 nasal spray), montelukast (Singulair)
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Bologna
Influenza
Tissue-specific Responses to Influenza Immunization and Their Relation to Blood Biomarkers (SLVP032)
The investigators collected blood and lymphoid tissues routinely discarded during surgery from adults after a routine seasonal influenza vaccination to determine how immune memory develops at the actual site of infection, and how…
- Trial name
- NCT03023709
- Testing
- Fluzone®, FluMist®
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obstructive Sleep Apnea
Evidence-based Diagnosis and Management of Pediatric Obstructive Sleep Apnea in Primary Care
Obstructive Sleep Apnea (OSA) is prevalent in children and adolescents and associated with a variety of negative consequences affecting health and cognitive functioning.
- Trial name
- NCT02781376
- Testing
- CHICA OSA, Snoring Identification Only
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Indiana University
Hypertension, Metabolic Disorder
The Effects of Obstructive Sleep Apnea and Its Intervention on Coronary Heart Disease
Obstructive sleep apnea(OSA) is an important identifiable cause of hypertension. Previous study has suggested that OSA significantly increases cardiovascular morbidity and mortality, especially in patients with pre-existing…
- Trial name
- NCT02059993
- Testing
- continuous positive airway pressure
- Volunteers
- 83 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Obstructive Sleep Apnea, Obesity
Impact of Smoking, Benzodiazepine (BZD) Use and Obesity on Severe Obstructive Sleep Apnea (sOSA)
In this study the investigators will analyze the influence of smoking, benzodizepine use, and obesity among patients with severe Obstructive Sleep Apnea (sOSA).
- Conditions
- Obstructive Sleep Apnea, Obesity, Smoking
- Trial name
- NCT02539264
- Testing
- Smoking, Obesity, Benzodiazepine use
- Volunteers
- 920 people
- Sponsor
- Astes
Snoring, Mouth Breathing
OA Therapy for Mouth-breathers Who Snore
Breathing is one of the body's vital functions that occur under normal conditions using the nose. When humans breathe primarily through the mouth instead of the nose, this is referred to as mouth breathing.
- Conditions
- Snoring, Mouth Breathing, Obstructive Sleep Apnea
- Trial name
- OATMB (NCT04876625)
- Testing
- myTAP oral appliance plus mouth shield, myTAP oral appliance alone for first 4 weeks
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Obstructive Sleep Apnea (OSA)
DAW2020 on OSA Endotypic Traits
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for…
- Trial name
- SedOSA (NCT04538755)
- Testing
- DAW2020 oral capsule
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Patient Compliance, Sleep Disorder
The Effects of Frequent Follow up on Compliance in Patients Receiving PAP Therapy Due to OSA (Pap: Positive Airway Pressure, OSA: Obstructive Sleep Apnea )
The investigators planned to investigate the effect of close monitoring on compliance and the factors affecting compliance among patients receiving PAP treatment due to OSA.This study was a single-center, prospective, randomized…
- Conditions
- Patient Compliance, Sleep Disorder, Obstructive Sleep Apnea of Adult
- Trial name
- NCT05894733
- Testing
- study group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Istanbul Sureyyapasa Chest Diseases and Chest Surgery Training and Research Hospital
Obstructive Sleep Apnea
Obstructive Sleep Apnea Among Somali-Americans
The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences.
- Trial name
- Somali OSA (NCT04124848)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnoea
Clinical Trial of a Rehabilitation Device Based on Electrostimulation for Obstructive Sleep Apnoea
The aim of this study is to evaluate in a clinical trial a rehabilitation device for patients with obstructive sleep apnoea (OSA) based on oropharyngeal electrical stimulation, which strengthens the dilating muscles of the upper…
- Trial name
- NCT04607343
- Testing
- Rehabilitation device based on electrical stimulation
- Where
- 2 sites in Colombia
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Fundación Neumologica Colombiana
Cardiac Diseases, Muscular Weakness
Biomarker for Pompe Disease (BioPompe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Pompe disease from blood (plasma)
- Conditions
- Cardiac Diseases, Muscular Weakness, Hepato-splenomegaly, Lung Disease
- Trial name
- BioPompe (NCT01457443)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Obstructive Sleep Apnoea, Hypopnoea Syndrome
The Effect of the Mediterranean Diet on Obstructive Sleep Apnoea-Hypopnoea Syndrome: A Randomised Trial
This study aims to investigate the role of the Mediterranean diet in obese patients with Obstructive sleep apnoea-hypopnoea syndrome.
- Trial name
- MEDOSAHS (NCT01312558)
- Testing
- Prudent diet group, Mediterranean diet group
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Crete
Hypoxia
Effect of Different Positions During Extubation on Incidence of Hypoxemia in the Peri Extubation Period
Pediatric Obstructive Sleep Apnea Syndrome (OSAS) is common, often due to enlarged tonsils/adenoids. Tonsillectomy/adenoidectomy frequently performed under GA with tracheal intubation due to the age of children.
- Trial name
- NCT07231887
- Testing
- positioning during peri-extubation
- Volunteers
- 262 people
- Sponsor
- Assiut University
Excessive Daytime Sleepiness, Obstructive Sleep Apnea (OSA)
Validating a Novel Driving Simulation-based MWT Against the Standard MWT in an OSA-cohort Challenged by CPAP-withdrawal
In brief, the proposed study will evaluate a recently proposed naturalistic, driving simulation test to identify and measure sleepiness behind the wheel, one of the most underestimated causes of road accidents.
- Conditions
- Excessive Daytime Sleepiness, Obstructive Sleep Apnea (OSA), CPAP Treatment, Driving Simulator Performance
- Trial name
- DS-MWT2 (NCT06872593)
- Testing
- CPAP-withdrawal, Test Sequence
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Stefan Lakämper
Obstructive Sleep Apnea, Gastroesophageal Reflux
Proton Pump Inhibitor Therapy for Mild to Moderate Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is common in modern society, affecting up to 5% of working middle-aged adults in the United States. Obesity is the number one risk factor for the development of OSA.
- Trial name
- NCT00211614
- Testing
- Lansoprazole
- Where
- United States
- Sponsor
- MetroHealth Medical Center
Obstructive Sleep Apnea
Efficacy Study of CPAP on Nitrate and Norepinephrine Levels in Severe and Mild-moderate Sleep Apnea (SABIO)
Reduced plasma nitrate (NOx) levels and increased urinary norepinephrine (U-NE) levels have been described in severe obstructive sleep apnea (OSA), and are reverted by continuous positive airway pressure (CPAP).
- Trial name
- SABIO (NCT01769807)
- Testing
- CPAP
- Where
- Portugal
- Volunteers
- 67 people
- Sponsor
- University of Lisbon
Obstructive Sleep Apnea
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs (NMBD). This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine…
- Trial name
- Sugammadex (NCT03679611)
- Testing
- Sugammadex Sodium, Neostigmine
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Sickle Cell Disease
Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events
Hypothesis is that the occurrence of nocturnal Vaso-Occlusive Crisis (VOC) and priapism in adults might be related to episodes of nocturnal desaturation secondary to a sleep apnea syndrome.
- Trial name
- DREPASOM (NCT02539771)
- Testing
- Polysomnography and blood sample
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea
Evaluation of a Nasal Mask for the Treatment of Obstructive Sleep Apnea in New Zealand
Currently, Fisher and Paykel Healthcare (FPH) is developing a new nasal mask. This investigation is designed to evaluate the performance of the trial nasal mask, focused specifically on how the different seal sizes will perform…
- Trial name
- NCT02541214
- Testing
- Trial Nasal Mask
- Where
- 2 sites in New Zealand
- Volunteers
- 39 people
- Sponsor
- Fisher and Paykel Healthcare
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