Clinical trials: OSAS
Obstructive Sleep Apnea
Whole Body Vibration for OSA
Obstructive Sleep Apnea (OSA) is a serious medical condition which is increasing in the United States and significantly increases risks for other diseases, morbidity and mortality.
- Trial name
- NCT03377621
- Testing
- Whole Body Vibration
- Where
- United States
- Sponsor
- University of California, Los Angeles
Obstructive Sleep Apnea
Arousal Analysis by Pulse Wave Amplitude in Patients With Obstructive Sleep Apnea
Photoplethysmography is an easy non-invasive method to detect the pulse wave amplitude (PWA) from a finger. This can be measured using the Somnocheck micro system.
- Trial name
- NCT01690429
- Testing
- Somnocheck micro
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Obstructive Sleep Apnea
Personal Therapy Comfort Settings Pilot Clinical Study
350 participants will be enrolled in this study. The target population are patients newly diagnosed with OSA and starting CPAP treatment.
- Trial name
- NCT05376137
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Australia
- Volunteers
- 66 people
- Sponsor
- ResMed
Obesity, Obstructive Sleep Apnea
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with obstructive sleep apnea (OSA) who are receiving positive airway…
- Trial name
- MARITIME-OSA-1 (NCT07225686)
- Testing
- Maridebart cafraglutide
- Where
- 61 sites in United States, Australia and 9 more
- Volunteers
- 250 people
- Sponsor
- Amgen
Apnea Syndrome
Comparison of Efficacy of Two Mandibular Advancement Devices (MADs) During Sleep
Mandibular Advancement Devices (MADs) are now a reliable alternative to continuous positive airway pressure (CPAP) treatments for Obstructive Sleep Apnea (OSA) .
- Trial name
- SONAR (NCT04474756)
- Testing
- custom-made adjustable mandibular advancement device
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea (OSA)
Atomoxetine and Oxybutynin in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- ATOSA (NCT02908529)
- Testing
- Combination product of Atomoxetine and Oxybutynin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Brigham and Women's Hospital
Respiratory Diseases
Oxidative Damage and Antioxidant Mechanisms in COPD
The environmental pollutants and endogenous reactive oxygen metabolites from inflammatory cells exert substantial pathological effects on the lung cells [1].
- Trial name
- NCT02406053
- Testing
- oxidative and antioxidant biomarkers
- Volunteers
- 111 people
- Sponsor
- Yuzuncu Yil University
Subjects With Moderate-to-severe OSA and Obesity Who Are on PAP Therapy
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of HRS9531 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Who Are on Positive Airway Pressure Ventilation (PAP) Therapy
This study is a phase 3 clinical trial, aiming to evaluate the efficacy and safety of HRS-9531 injection in obese subjects with obstructive sleep apnea (OSA) who are on positive airway pressure ventilation (PAP) therapy.
- Trial name
- NCT06994650
- Testing
- HRS9531
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Obstructive Sleep Apnea, Acute Coronary Syndrome
Attentional Capacity and Working Memory in Coronary Artery Disease Patients: Impact of the Presence of a Sleep Apnea Syndrome and Chronic Effects of Treatment With CPAP
The presence of Obstructive Sleep Apnea Syndrome (OSAS) has a high frequency in patients victims of a coronary artery disease (CAD) (myocardial infarction, revascularization).
- Trial name
- CAPCORSAS (NCT02533050)
- Testing
- CPAP treatment
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sleep Apnea, Obesity
Sleep Apnea-Hypopnea Syndrome and the Pathogenesis of Obesity
The hypothesis of the study is the following: Patients with sleep apnea-hypopnea syndrome have different pattern in the secretion of hormones.
- Trial name
- NCT00456651
- Testing
- CPAP (Continuous Positive Airway Pressure)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnea
Evaluation of an Incentive-based Intervention to Improve 90-day Adherence in PAP-Naive Patients
This is a prospective, randomized, open-label study to evaluate effectiveness of applying financial and social incentives via a smartphone-based app in helping participants achieve adherence to PAP therapy.
- Trial name
- Project Dahlia (NCT03851094)
- Testing
- Wellth app
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- ResMed
Obstructive Sleep Apnea, Down Syndrome (Trisomy 21)
Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down Syndrome
Obstructive Sleep Apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep, inducing breathing disturbances that can result in oxygen desaturation and frequent arousals.
- Trial name
- OMF21 (NCT07195253)
- Testing
- Polysomnography (PSG) to explore OSA, Oro-myo-functional clinical evaluation, Sleep Disturbance Scale for Children
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Obstructive Sleep Apnea (OSA), Snoring
The Impact of Technology in Obstructive Sleep Apnea Myofunctional Therapy
This is a study to test if performing airway exercises to improve snoring and sleep apnea using a mobile phone app is better than using a hardcopy guide.
- Conditions
- Obstructive Sleep Apnea (OSA), Snoring, Sleep Quality
- Trial name
- OSA (NCT06905951)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Case Western Reserve University
Asthma, Obstructive Sleep Apnea Syndrome
Factors Issued From Functional Exploration Associated to SAHOS in Asthmatic Children
There is an increase in the prevalence of obstructive apnea-hypopnea syndrome (OSA) in children for which the pathophysiological explanation is unknown.
- Trial name
- SASTHMA (NCT04624815)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sleep Apnea, Obstructive, Sleep Apnea
Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea
Drug-induced sleep endoscopy (DISE) is the most used technique for identifying the obstruction site associated with obstructive sleep apnea (OSA).
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Sleep Apnea Syndromes, Apnea
- Trial name
- NCT04729478
- Testing
- Drug-induced sleep endoscopy, Natural sleep endoscopy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- ethisch.comite@uza.be
Obstructive Sleep Apnea
Automated Graduated CPAP (AGPAP) for Improved Adherence in Newly Diagnosed Obstructive Sleep Apnea (OSA) Patients
Although positive airway pressure (PAP) is a highly effective treatment for sleep apnea, adherence to therapy remains an obstacle.
- Trial name
- NCT01450540
- Testing
- REMstar Auto A-Flex, modified REMstar Auto A-Flex with AGPAP
- Where
- 5 sites in United States
- Volunteers
- 241 people
- Sponsor
- Philips Respironics
Obstructive Sleep Apnea
Sleep Apnea Study in Adults Using DreamPort-Eclipse and a Traditional Nasal Mask
The Randomized Controlled Trial of Bleep DreamPort-Eclipse Study is a two-arm, randomized, prospective, non-blinded study to assess the effectiveness of the novel CPAP human interface design to improve leak, AHI, and pressure…
- Trial name
- NCT05818540
- Testing
- Eclipse novel CPAP mask, ResMed P-10 mask
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Bleep, LLC
Obstructive Sleep Apnea, Secondary Hypertension
Obstructive Sleep Apnea and Endothelial Function in Patients With Resistant Hypertension
The purpose of this study is to determine the prevalence of obstructive sleep apnea and associate it with the endothelial function behavior in patients with resistant hypertension.
- Trial name
- NCT01854190
- Testing
- WatchPAT
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Rio de Janeiro State University
Obstructive Sleep Apnoea (OSA)
Effect of Bariatric Surgery on Obstructive Sleep Apnea in a Danish Cohort
Studies have shown high prevalence (60-94%) of obstructive sleep apnoea (OSA) among patients undergoing bariatric surgery. Fifteen studies are published investigating the effect of bariatric surgery on OSA.
- Trial name
- NCT02012868
- Testing
- bariatric surgery
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- University of Southern Denmark
Obstructive Sleep Apnea (OSA), Polysomnography
Multimodal Deep Learning Model for Predicting the Apnea-Hypopnea Index in Obstructive Sleep
This study aims to develop a multimodal deep learning model that integrates noninvasive signals to predict the severity of obstructive sleep apnea.
- Trial name
- NCT07447999
- Testing
- electronic stethoscope, fingertip pulse oximeter, pressure-sensing mattresses
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Fu Jen Catholic University
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