Clinical trials: OSAS
Obstructive Sleep Apnea
The Effect of CPAP Treatment on Cognitive Functions, Anxiety, and Affective Symptoms
Long term, prospective study of continuous positive airway pressure treatment influence on cognitive functions in patients with obstructive sleep apnea syndrome.
- Trial name
- NCT03866161
- Testing
- Continuous positive airway pressure
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Olomouc
Sleep Disorder, Sleep Apnea Syndromes
Respiratory Rehabilitation in Obstructive Sleep Apneas
The Obstructive Sleep Apnea is characterized by obstruction of the upper airway during sleep (for at least 10 sec), with repeated breathing pauses, accompanied by oxygen desaturation in the blood and by sleep interruption with…
- Trial name
- OSA20 (NCT04412941)
- Testing
- Myofunctional exercises, The rules of sleep hygiene
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Obstructive Sleep Apnea
Effects of Continuous Positive Airway Pressure (CPAP) in Heart Remodeling by Magnetic Resonance Imaging (MRI)
Obstructive sleep apnea (OSA) is independently associated with important heart remodeling that further contributes to overt heart failure.
- Trial name
- OSA-MRI (NCT00727454)
- Testing
- CPAP, No treatment
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea, Alzheimer Disease
ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in…
- Conditions
- Obstructive Sleep Apnea, Alzheimer Disease, Vascular Dementia, Mild Cognitive Impairment
- Trial name
- ENCHANT (NCT04335994)
- Testing
- In-laboratory polysomnography, Home Sleep Apnea Test
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Obstructive Sleep Apnea
The Effects of Nasal Airflow on Upper Airway Dilator Muscles During Sleep
Obstructive sleep apnea (OSA) is an increasingly prevalent disorder characterized by repeated upper airway collapse during sleep, resulting in oxygen desaturation and frequent arousals. The etiology of OSA remains unclear.
- Trial name
- NCT03506178
- Testing
- Oxymetazoline Nasal Spray, Menthol Nasal Spray, Normal saline Nasal Spray
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Obstructive Sleep Apnea
SleepFlexTM Treatment of Obstructive Sleep Apnea
The purpose of this study is to evaluate the safety and effectiveness of the SleepFlex program for treatment of mild to moderate OSA
- Trial name
- NCT04726514
- Testing
- SleepFlex
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Berendo Scientific, LLC
Obstructive Sleep Apnea
Propranolol for Sleep Apnea Therapy
The primary objective of this study is to test whether a beta blocker, propranolol, lowers the overnight heart rate sleep in obstructive sleep apnea (OSA) during CPAP withdrawal.
- Trial name
- ProSAT (NCT03049306)
- Testing
- Propranolol Oral Tablet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
OSA
Evaluation in Patients With Obstructive Sleep Apnea That Had Undergone Diagnosis and Surgical Treatment
Drug induced sleep endoscopy (DISE) is an increasingly performed procedure, offering dynamic upper airway evaluation during artificial sleep before surgical treatment for patients with obstructed sleep apnea (OSA).
- Trial name
- NCT02977338
- Testing
- Retrospective review
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Snoring, Obstructive Sleep Apnea
Prospective Evaluation of a Palato-Pharyngeal Implant System (PPIS) Obstructive Sleep Apnea Syndrome (OSAS)
Prospective Evaluation of a Palato-Pharyngeal Implant System (PPIS) for the Treatment of Snoring and Obstructive Sleep Apnea Syndrome (OSAS): A Pilot Study.
- Trial name
- NCT03640793
- Testing
- Implantation
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Medartis AG
Obstructive Sleep Apnea, Obesity
A Study of Surgical Weight Loss to Treat Obstructive Sleep Apnea
Obesity is an increasing problem worldwide. Over 20% of people in western societies are obese (BMI >30kg/m2) and 1-2 % are morbidly obese (BMI >40 kg/m2).
- Trial name
- NCT01080404
- Testing
- Bariatric surgery, Continuous positive airway pressure
- Where
- 9 sites in Finland
- Volunteers
- 197 people
- Sponsor
- Kuopio University Hospital
Obstructive Sleep Apnea
Validation of the ApneaLink Sleep Screener for Obstructive Sleep Apnea (OSA)
The primary endpoints for this study are that the AL validation will 1) achieve a sensitivity of greater than 80% for AHI values greater than or equal to 15, and 2) demonstrate a correlation coefficient of r=0.75 indicating…
- Trial name
- NCT00354614
- Testing
- ApneaLink Sleep Screener
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
Determinants of Tooth Movement in Oral Appliance Treatment of OSA.
Obstructive sleep apnea (OSA) is a sleep related breathing disorder, affecting approximately 10% of adults. Mandibular advancement oral appliances (OAM) are an effective treatment for OSA, however, long term use has shown to lead…
- Trial name
- TACO (NCT03341130)
- Testing
- Mandibular Repositioning Splint, Mandibular Advancement Oral Appliance
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea
Acetazolamide on REM OSA
OSA is a highly prevalent disorder that has major consequences for cardiovascular health, neurocognitive function, risk of traffic accidents, daytime sleepiness and quality of life.
- Trial name
- RemmOSA (NCT05589792)
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea Syndrome
Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients
To study the effect of Xyrem (9 g), Xyrem (9 g) plus modafinil 200 mg administered the morning prior to Xyrem, positive control (zolpidem 10 mg), and placebo on the frequency and outcome of events of sleep-disordered breathing in…
- Trial name
- NCT00086281
- Testing
- Xyrem (X), Zolpidem (Z), Modafinil (M)
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Jazz Pharmaceuticals
Obstructive Sleep Apnea (OSA)
Post-extubation Boussignac CPAP System in Adults With Moderate to Severe Obstructive Sleep Apnea
The purpose of this study is to assess the efficacy of the Boussignac positive airway pressure system (a mask) applied immediately following post-operative extubation in improving lung function in patients with obstructive sleep…
- Trial name
- NCT01877928
- Testing
- Boussignac CPAP device, standard CPAP
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Queen's University
Obstructive Sleep Apnea
Impact of Automated Education and Follow-up Mechanisms on Patient Engagement
The primary and well-known challenge with continuous positive airway pressure (CPAP) is the incomplete adherence of patients to this therapy.
- Trial name
- EmmiUSleep (NCT02279901)
- Testing
- Telemedicine Education, IVR
- Where
- United States
- Volunteers
- 1,873 people
- Sponsor
- Kaiser Permanente
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Obstructive Sleep Apnea
Optimal Dosage of Acetazolamide for OSA Treatment
Acetazolamide, a carbonic anhydrase inhibitor, has received some attention as potential treatment for obstructive sleep apnea (OSA).
- Trial name
- NCT04726982
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 91 people
- Sponsor
- University Hospital, Antwerp
Sleep Apnea, Diabetes
Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy
This is a randomized control trial in people with diabetes and obstructive sleep apnea who will be randomly assigned for 3 months to PAP therapy along with healthy lifestyle and sleep education or healthy lifestyle and sleep…
- Trial name
- HYPNOS (NCT02454153)
- Testing
- REMStar Positive Airway Pressure, LifeStyle Counseling
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Johns Hopkins University
Obstructive Sleep Apnea
Peer-Driven Intervention for Sleep Apnea
Fragmentation of care can lead to poor treatment adherence in patients with chronic medical conditions which can, in turn, lead to adverse health consequences, poor quality of life, and patient dissatisfaction.
- Trial name
- PCORI (NCT02056002)
- Testing
- Usual Care, Peer-Buddy System
- Where
- United States
- Volunteers
- 362 people
- Sponsor
- University of Arizona
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