Clinical trials: Obese Adults
GLP-1, Obesity &Amp; Overweight
Effect of a Dietary Supplement on Hormones Involved in Appetite Regulation in Overweight and Obese Adults
Obesity is a chronic condition linked to numerous health risks and affects more than one billion people worldwide. While pharmacological treatments such as incretin-based therapies are available, they may have side effects, are…
- Conditions
- GLP-1, Obesity &Amp; Overweight, Dietary Supplement
- Trial name
- NCT07240246
- Testing
- Intervention: Dietary Supplement with Plant Extracts
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- FFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & Innovation
Time Restricted Feeding, Exercise
Time-Restricted Eating, Exercise and Cardiometabolic Health in Obesity
In Spain, overweight and obesity prevalence is reaching 70% in men and 50% in women. Excess of triglycerides are usually stored in the subcutaneous adipose tissue (SAT), until a point where SAT is unable to expand further.
- Conditions
- Time Restricted Feeding, Exercise, Hepatic Steatosis, Cardiometabolic Syndrome
- Trial name
- TEMPUS (NCT05897073)
- Testing
- Time-restricted eating intervention, Exercise intervention, Time-restricted eating plus exercise intervention
- Where
- 2 sites in Spain
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Obesity
Effect of High Intensity Aerobic & Resistance Interval Training on Body Composition, Visceral Adiposity and Myocardial Function in Overweight and Obese Adults
The obesity epidemic, predisposing to cardio-metabolic diseases, has increased two-folds over the last decade with a global alarming cost of obesity-associated illnesses, thus representing a grave peril for the survival of public…
- Trial name
- NCT04708873
- Testing
- High intensity interval training, Moderate Intensity Continuous Training
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Foundation University Islamabad
Ferritin, Insulin Sensitivity
Blood Donation Could Improve Insulin Sensitivity
Studies in the literature suggest that people with obesity have an excess of stored iron. There is possibly an inverse relationship between ferritin levels and the actions of insulin on glycemic control.
- Conditions
- Ferritin, Insulin Sensitivity, Blood Donation
- Trial name
- GLUCFER (NCT05791968)
- Testing
- Whole blood standard donation
- Where
- Spain
- Volunteers
- 89 people
- Sponsor
- University of Castilla-La Mancha
Obesity, Depression
Engaging Self-regulation Targets to Improve Mood and Weight and Understand Mechanism in Depressed and Obese Adults
Multimorbidity (i.e., the coexistence of 2 or more chronic conditions in an individual) is increasingly recognized as a pressing public health problem.
- Trial name
- NCT03841682
- Testing
- I-CARE2
- Where
- 2 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Overweight and Obesity
Water Intake and Weight Control in Older Adults
This study is a randomized controlled intervention trial in adults aged 50+ years with overweight or obesity, which will compare three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each…
- Trial name
- NCT05843318
- Testing
- Water intake and weight control in older adults - Premeal Water + hypocaloric diet, Water intake and weight control in older adults - Total Daily Water + hypocaloric diet, Water Intake and weight control in older adults - hypocaloric diet alone
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity
An Anti-inflammatory Diet Effect on Metabolic, Inflammatory and Immune Status of Obese Younger Adults
Diet has a major role in the etiology of obesity, and there is a growing body of evidence suggesting that a variety of dietary factors can modulate obesity-induced chronic low-grade inflammation and thus the course of…
- Trial name
- NCT03987776
- Testing
- Anti-inflammatory energy-restricted diet, Control energy-restricted diet
- Where
- Croatia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Obesity
Effect of Aerobic Exercise Training in Obese Adults
To determine the effect of aerobic exercise training on arterial stiffness and hemodynamics in obese adults. Proper evidence on the effect of aerobic exercise training on both arterial stiffness and hemodynamics are sparsely…
- Trial name
- NCT05202535
- Testing
- Aerobic exercise training, Conventional therapy
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Obesity, Metabolic Syndrome
Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)
This study investigates whether the activity of brown adipose tissue (BAT) - a special type of fat that burns energy as heat - can predict how well individuals with obesity respond to semaglutide (Wegovy), a once-weekly…
- Conditions
- Obesity, Metabolic Syndrome, Brown Adipose Tissue
- Trial name
- BAT-Sema (NCT07621640)
- Testing
- Semaglutide (Wegovy®), ¹⁸FDG-PET/CT with cold stimulation, Liver MRI (PDFF + MRE)
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Hallym University
Bardet-Biedl Syndrome
Characterizing the Genotype and Phenotype in Adults With Bardet-Biedl Syndrome
Bardet-Biedl syndrome (BBS; OMIN #209900) is a rare genetic disorder characterized by six core features: rod-cone dystrophy (retinitis pigmentosa), polydactyly, obesity, genital anomalies, renal anomalies, and learning…
- Trial name
- NCT05400278
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Type II Diabetes Mellitus
Efficacy and Safety of GL0034 in Overweight or Obese Adults With Type II Diabetes Mellitus
This is a phase II, randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of GL0034 among type II diabetes mellitus subjects who are obese or overweight with weight-related comorbidities.
- Trial name
- NCT07282743
- Testing
- GL0034 Dose Level 1, GL0034 Dose Level 2, GL0034 Dose Level 3
- Where
- 21 sites in United States, India
- Volunteers
- 285 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Obesity & Overweight, Type 2 Diabetes
A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers
Phase 1 Safety and Relative Bioavailability Study of DWRX5003 in Healthy Adults
- Trial name
- NCT07539415
- Testing
- DWRX5003, DWC202502, DWC202503
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Body Weight, Body Weight Changes
Online Family Dyadic Skills Training for Black Adults in Behavioral Weight Loss Program
The purpose of this research study is to test the feasibility and acceptability of an interactive counselor -led online family skills training as part of a behavioral weight loss program for Black Adults.
- Conditions
- Body Weight, Body Weight Changes, Obesity, Overweight and Obesity
- Trial name
- TEAM+ (NCT05981508)
- Testing
- Together, Eating and Activity, Matter Plus (TEAM+) Online, Together, Eating and Activity, Matter Plus (TEAM+) In-Person
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Obesity
Adults Regulating Their Weight Everyday With Mobile Internet Support
Adults Regulating Their weight Everyday with Mobile Internet Support (ARTEMIS) is a randomised controlled trial evaluating the effectiveness of a mobile app based weight loss intervention designed to increase self-regulation in…
- Trial name
- ARTEMIS (NCT05787652)
- Testing
- ARTEMIS mobile app
- Where
- United Kingdom
- Volunteers
- 1,294 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Alcohol Use Disorder, Obesity and Overweight
Tirzepatide for Alcohol Use Disorder
The objective of this Phase 2 randomized controlled trial is to evaluate the effects of weekly tirzepatide (vs. placebo) on alcohol consumption and cardiometabolic outcomes in adults with alcohol use disorder and overweight or…
- Conditions
- Alcohol Use Disorder, Obesity and Overweight, Alcohol
- Trial name
- NCT06994338
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Southern California
Diabetes, Pre-diabetes
Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM)
The investigators know that metformin works at the level of the cells in the body by acting on a protein called Cyclic amine monophosphate- Response Binding Elements (CREB) binding protein or Constitutive Reverter of eIF2α…
- Conditions
- Diabetes, Pre-diabetes, Obesity
- Trial name
- NCT01876992
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hypertension, Hyperlipidemias
Clinical Trials of Two Helichrysum Infusions in Adults
The study evaluates the effects of Helichrysum italicum and Helichrysum Arenarium on different components of the metabolic syndrome.
- Conditions
- Hypertension, Hyperlipidemias, Inflammation, Hyperglycemia
- Trial name
- SMILJ (NCT04866628)
- Testing
- Helichrysum italicum infusion, Helichrysum arenarium
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Obesity & Overweight
Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity
To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity.
- Trial name
- NCT07444736
- Testing
- Intervention
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Centro Universitario de Tlajomulco, Universidad de Guadalajara
Oxidative Stress, Obesity
Acute Effect of Apple Cider Vinegar on Postprandial Plasma Malondialdehyde in Adult With Obesity
Research on the benefits of apple cider vinegar has tended to focus on its hypoglycemic effects and lipid profile changes during long-term consumption, without exploring its acute effects on oxidative stress during short-term…
- Trial name
- NCT07414875
- Testing
- apple cider vinegar
- Where
- Indonesia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Obesity, Older Adults
Investigating Fitness Interventions in the Elderly (INFINITE)
Aging is associated with declines in aerobic capacity, exercise tolerance, and functional endurance that lead to physical disability and loss of independence.
- Conditions
- Obesity, Older Adults, Sedentary
- Trial name
- INFINITE (NCT01048736)
- Testing
- Exercise Only, Exercise + Diet
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences