Clinical trials: Obese Diabetics
Obstructive Sleep Apnea
Autonomic Function in Obstructive Sleep Apnea
The purpose of this study is to determine if obstructive sleep apnea (OSA) causes autonomic dysfunction independent of its effects on hyperglycemia.
- Trial name
- NCT00681161
- Testing
- continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Vanderbilt University
Non-arteritic Anterior Ischemic Optic Neuropathy Obesity, Obesity
NAION in Non-Diabetic Obese Patients Using GLP-1 Receptor Agonists: A Real-World Study
Non-arteritic anterior ischemic optic neuropathy (NAION) is one of the most common causes of sudden, painless, usually unilateral vision loss in adults over 50 years of age, and no proven effective treatment exists.
- Trial name
- NCT07846956
- Testing
- GLP-1 Receptor Agonist Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Istanbul Saglik Bilimleri University
Obesity
A 1-Year Study On The Effects Of CP-945,598 For The Treatment Of Obesity In Overweight Type 2 Diabetic Patients
The purpose of this study is to determine if CP-945,598 is effective in the treatment of obesity in type 2 diabetic patients.
- Trial name
- NCT00391196
- Testing
- CP-945,598, CP-945,598 Treatment B
- Where
- 91 sites in United States, Argentina and 9 more
- Volunteers
- 975 people
- Sponsor
- Pfizer
Inflammation
Effect of Pioglitazone on Oxidative Load, Inflammatory End-Points and Vascular Reactivity in Obese Non-Diabetic Patients: A Dose Ranging Study
Pioglitazone decreases oxidative load, inflammatory end points and improves vascular reactivity in obese patients in a dose dependent manner and that this effect is independent of its glucose lowering effects.
- Trial name
- NCT01161394
- Testing
- Pioglitazone 15mg, pioglitazone 30mg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Diabetes Mellitus Type 2 in Obese
Efficacy of SASI Bypass for Type-2 Diabetic Obese Patients
the investigator modified the Sanator's operation by performing a loop rather than Roux-en-Y bipartition reconstruction and the investigator are reporting the first clinical results of the outcomes of SASI bypass as a mode of…
- Trial name
- SASI (NCT02680873)
- Testing
- SASI bypass
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Type 2 Diabetes, Coronary Artery Disease
Enhancing Adherence by Building Online Communities
The purpose of this study is to determine whether online peer support will increase adherence to an internet-based pedometer walking program.
- Conditions
- Type 2 Diabetes, Coronary Artery Disease, Obesity
- Trial name
- NCT00729040
- Testing
- Stepping Up to Health
- Volunteers
- 324 people
- Sponsor
- Robert Wood Johnson Foundation
Hypercholesterolemia, Diabetes
Does Simvastatin Affect Insulin Sensitivity in Dyslipidemic Type 2 Diabetic Patients?
We aimed to address the issue whether statins affect insulin resistance. To this end, we combined the available state-of-the art technology for detailed assessment of both whole-body and tissue specific insulin sensitivity in…
- Conditions
- Hypercholesterolemia, Diabetes, Cardiovascular Disease
- Trial name
- NCT00704314
- Testing
- Simvastatin
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Obesity, Pregnancy in Diabetic
Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes
The obesity epidemic is growing worldwide and in the UK this is perpetuated with a third of women classified as overweight/obese in 2020.
- Conditions
- Obesity, Pregnancy in Diabetic, Pregnancy Complications, Pregnancy Related
- Trial name
- NCT05753124
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Type 2 Diabetes Mellitus
Gastric Modulator (TANTALUS® System) Versus Insulin Treatment in Obese Type 2 Diabetic Patients - a Randomized Control Trial
This study aims to analyze the pre- and post-operative clinical, hormonal and biochemical changes in moderately obese type 2 diabetic patients who are sub-optimally controlled on at least 2 anti-diabetic agents.
- Trial name
- NCT00975533
- Testing
- Tantalus, Insulin
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus in Obese
Dietary Intake, Eating Behavior, Physical Activity Level and Their Relationships With Glycemic and Weight Control in Hong Kong Chinese Type 2 Diabetic Patients
The objective of this study is to describe and examine the dietary intake, eating behavior and physical activity level of a cohort of Hong Kong Chinese with T2DM and their association with weight and glycemic control at baseline…
- Trial name
- NCT02937987
- Volunteers
- 211 people
- Sponsor
- Chinese University of Hong Kong
Diabetes-related Complications
Myocardial Regional Function by Dobutamine Stress Echocardiography in the Metabolic Syndrome and Type 2 Diabetes
Summary. Theoretical Rationale: The left ventricular myocardial performance results from a complex interplay between linear deformations (longitudinal, circumferential and radial) and twist/ untwist mechanics.
- Trial name
- NCT02505451
- Testing
- dobutamine
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Obesity, Insulin Resistance
The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults
The primary aim of this study is to evaluate the effect of exenatide on daily glycemic excursions obtained by continuous glucose monitoring system (CGMS).
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00845559
- Testing
- Exenatide
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Obesity, Diabetes
Residual Gastric Volume in Morbidly Obesa Diabetics. A Comparison of 3 Hour Versus Hour Fasting.
To reduce the risk of aspiration for elective procedures, residual gastric volumes (RGV) have traditionally been minimized with overnight fasting.
- Conditions
- Obesity, Diabetes, Fasting
- Trial name
- NCT02114008
- Testing
- Endoscopic examinations
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- Cuiaba University
Diabetes, Obesity
Evaluation of Morbidities, Endpoints and Reaching Targets in Diabetic Patients Managed by a Diabetes Specialist Team
This is a pilot translational study aiming to compare the effects of a multi-component care program with personalized drug regimen augmented by behavioural therapy with psychological support and peer influence, led by a diabetes…
- Trial name
- EMERALD (NCT01690208)
- Testing
- EMERALD, Usual Care
- Where
- Hong Kong
- Volunteers
- 600 people
- Sponsor
- Asia Diabetes Foundation
Type 2 Diabetes, Diabetes Type 2
Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study
The current protocol plans to enroll participants with youth-onset Type 2 Diabetes (T2D) as well as obese and lean controls from the Renal-HEIR - Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2…
- Conditions
- Type 2 Diabetes, Diabetes Type 2, Diabetic Nephropathies, Nephropathy
- Trial name
- HEIRitage (NCT05530356)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes Mellitus, Obesity
Effects of Rosiglitazone on Serum Ghrelin and Peptide YY Levels
We aimed to evaluate the effects of rosiglitazone on serum ghrelin and peptide yy levels in diabetic women.
- Trial name
- NCT00522470
- Testing
- rosiglitazone
- Where
- Turkey (Türkiye)
- Sponsor
- Baskent University
Proteinuric Kidney Disease, Diabetic Nephropathy
Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease
Primary Hypothesis: Aldosterone breakthrough will occur at a far lower frequency during renin inhibition (0-10% over 9 months), alone or in combination with an ARB, compared to conventional ARB therapy (35-45% over 9 months).
- Conditions
- Proteinuric Kidney Disease, Diabetic Nephropathy, Hypertensive Nephrosclerosis, IgA Nephropathy
- Trial name
- NCT01129557
- Testing
- Aliskiren, Valsartan
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Columbia University
Obesity
Gut Microbiome Changes Following Liraglutide Treatment in Obese Subjects or Overweight Subjects With Co-morbidities
We performed a multicenter, randomized, double-blind, placebo-controlled 28-week trial. 300 non-diabetic obese subjects or overweight subjects with co-morbidities were randomly assigned.
- Trial name
- NCT04525300
- Testing
- Liraglutide
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xiangya Hospital of Central South University
Type II; Diabetes, Obesity
Social Incentives to Improve Diabetes
In this study, we will conduct a one-year, four-arm, randomized, controlled trial to compare three social incentive-based gamification interventions to control for promoting physical activity and weight loss toward improved…
- Trial name
- iDiabetes (NCT02961192)
- Testing
- Supportive social incentive, Competitive social incentive, Collaborative social incentive
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Pennsylvania
Diabetes, Nonalcoholic Fatty Liver Disease
Effects of Exercise on Patients With Nonalcoholic Fatty Liver Disease- A Comparative Randomized Controlled Trial
background: Obesity, diabetes mellitus type II and fatty liver disease combining with low levels of physical activity are prominent health risks for mortality and morbidity.
- Conditions
- Diabetes, Nonalcoholic Fatty Liver Disease, Obesity, Exercise
- Trial name
- [PTREC] (NCT03774511)
- Testing
- High-Intensity Interval Exercise & Moderate Intensity Interval Exercise
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Ahlia University